期刊
SOFT MATTER
卷 11, 期 9, 页码 1748-1754出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sm02499k
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资金
- National Natural Science Foundation of China [201103031, 21373270]
- Fundamental Research Funds for the Central Universities [14CX06033A, 27R1104057A]
- Program for New Century Excellent Talents in University [NCET-11-0735]
- UK Engineering and Physical Sciences Research Council (EPSRC) [EP/F062966/1]
- EPSRC [EP/F062966/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F062966/1] Funding Source: researchfish
This work describes the design and preparation of a simple but novel hybrid amphiphile containing a pH-responsive DNA sequence. The formation of a bimolecular i-motif structure allows the control of reversible switching of the hybrid amphiphile between the dimer and unimer by pH. Thus, spherical aggregates with distinct self-assembly pathways, sizes and structures are obtained at pH 4.5 and pH 9.0, and the structures can be switched by the change of pH and thermal annealing. This work reports different self-assembled nanostructures and their transitions that give this amphiphile potential for the design of controllable drug delivery systems.
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