Article
Obstetrics & Gynecology
Steven L. Clark
Summary: The evolution of continuous electronic fetal heart rate monitoring has presented obstetricians with a dilemma: while basic science observations suggest a potential link to improved neurological outcomes, evidence is lacking after decades of use. This may be due to widespread misconceptions regarding FHR patterns and cerebral palsy, reliance on anecdotal experience and tradition, and the view of fetal monitoring as an indivisible entity.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell & Tissue Engineering
Joanne O. Davidson, Lotte G. van den Heuij, Mhoyra Fraser, Guido Wassink, Suzanne L. Miller, Rebecca Lim, Euan M. Wallace, Graham Jenkin, Alistair J. Gunn, Laura Bennet
Summary: Even up to 24 hours after hypoxia-ischemia, a single infusion of hAECs shows anti-inflammatory, anti-gliotic, and neuroprotective effects in preterm fetal sheep. However, the protection on white matter is limited, and there is no improvement in the recovery of EEG power.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Brenda Reyes-Sotelo, Asahi Ogi, Patricia Mora-Medina, Chiara Mariti, Adriana Olmos-Hernandez, Ismael Hernandez-Avalos, Adriana Dominguez-Oliva, Marcelino Evodio Rosas, Antonio Verduzco-Mendoza, Angelo Gazzano
Summary: This study evaluated the impact of dam's size, birth order, and blood gas alterations on canines. The results indicate that the dam's size and birth order have significant physiological and metabolic effects on puppies, with variations observed in different-sized dogs.
Article
Neurosciences
Nhi T. Tran, Anna M. Muccini, Nadia Hale, Mary Tolcos, Rod J. Snow, David W. Walker, Stacey J. Ellery
Summary: Background: Creatine supplementation during pregnancy is a potential treatment for perinatal hypoxic brain injury. This study investigated the effects of acute hypoxia and creatine supplementation on neuropathology in fetal sheep. Results: Acute hypoxia caused mild injury to multiple brain regions, but creatine supplementation did not ameliorate these changes. However, creatine supplementation did affect gene expression that may impact in utero cerebral development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Robert Galinsky, Simerdeep K. Dhillon, Sharmony B. Kelly, Guido Wassink, Joanne O. Davidson, Christopher A. Lear, Lotte G. van den Heuij, Laura Bennet, Alistair J. Gunn
Summary: Maternal magnesium sulphate (MgSO4) treatment before preterm birth for neuroprotection is controversial due to limited evidence of long-term neuroprotection. In this study, preterm fetal sheep received MgSO4 infusion before hypoxia-ischaemia induced by umbilical cord occlusion. Although MgSO4 showed moderate improvements in white and grey matter gliosis and myelin density, it did not improve EEG maturation, neuronal or oligodendrocyte survival.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Karolina Przepiorska, Agnieszka Wnuk, Cordian Beyer, Malgorzata Kajta
Summary: Amorfrutin B is identified as a selective modulator of the PPAR gamma receptor with neuroprotective properties against hypoxic and ischemic damage in brain neurons. The delayed post-treatment with amorfrutin B prevents neuronal apoptosis by preserving mitochondrial function, inhibiting heterochromatin foci formation, and modulating the expression of specific genes and proteins. The protective mechanisms of amorfrutin B involve the inhibition of autophagy and the regulation of apoptosis-focused and autophagy-related miRNAs. Amorfrutin B shows promise as an anti-stroke therapeutic with a wide treatment window.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, General & Internal
Arshad Khushdil, Zeeshan Ahmed, Azra Ehsan
Summary: An observational cohort study was conducted at Neonatal Intensive Care Units of two military hospitals to investigate the effects of citicoline in neonates diagnosed with moderate to severe hypoxic ischemic encephalopathy. The study showed promise in the treatment of newborns with moderate to severe birth asphyxia, with most newborns discharged after receiving treatment.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Review
Pediatrics
Aisa Shayo, Pendo Mlay, Emily Ahn, Hussein Kidanto, Michael Espiritu, Jeffrey Perlman
Summary: Early neonatal mortality (ENM) remains a significant problem in low resource settings. This study found that birth weight and gestational age were key factors affecting ENM, and fetal heart rate abnormalities and hypothermia were closely associated with ENM. A comprehensive perinatal approach is necessary to achieve a sustained reduction in ENMR.
Article
Pediatrics
Maria Luisa Mayol Perez, Jose Manuel Hernandez Garre, Paloma Echevarria Perez
Summary: This study found that factors such as gestational age at term, primiparity, induced labor, vaginal delivery, and prolonged labor duration may decrease umbilical artery pH variability at birth. However, only induction of labor, vaginal delivery, and total labor duration are associated with fetal acidosis of less than 7.20 pH.
FRONTIERS IN PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Jacques Lepercq, My-Anh Nghiem, Francois Goffinet
Summary: This study found that a fetal bradycardia nadir of less than 60 bpm is significantly associated with an increased risk of umbilical artery acidemia at birth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Pediatrics
Desalegn Tesfa, Sofonyas Abebaw Tiruneh, Melkalem Mamuye Azanaw, Alemayehu Digssie Gebremariam, Melaku Tadege Engidaw, Mulu Tiruneh, Tsion Dessalegn, Melkamu Aderajew Zemene, Ermias Sisay
Summary: By using simple maternal and neonatal characteristics, we have developed a risk score tool for predicting birth asphyxia and identified important predictors. This tool has good predictive ability and can help reduce morbidity and mortality related to birth asphyxia, improving child health in low-income countries.
Article
Multidisciplinary Sciences
Gurman Kaur, Caroline B. M. Porter, Orr Ashenberg, Jack Lee, Samantha J. Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E. Attfield, Christiane A. E. Desel, Jessica L. Davies, Hayley G. Evans, Inbal Avraham-Davidi, Lan T. Nguyen, Danielle A. Dionne, Anna E. Neumann, Lise Torp Jensen, Thomas R. Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Summary: This study demonstrates that the interaction between maternal KIR2DL1 and paternal HLA-C*0501 leads to fetal growth restriction in a humanized mouse model. The authors show that this interaction affects uterine arterial remodeling and uterine NK cell function, leading to altered transcriptional expression and intercellular communication at the maternal-fetal interface.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tsuyoshi Murata, Hyo Kyozuka, Shun Yasuda, Toma Fukuda, Teruyoshi Tanaka, Keiya Fujimori
Summary: This study investigated the effects of maternal ritodrine hydrochloride administration on fetal physiological parameters and its modification under intraamniotic inflammation. Short-term administration of ritodrine hydrochloride significantly increased fetal heart rate and variability, which were further modified under intraamniotic inflammation.
Article
Multidisciplinary Sciences
Albertine Enjema Njie, Winstone Mokaya Nyandiko, Phinehas Ademi Ahoya, Jude Suh Moutchia
Summary: This study compared the effectiveness of APGAR scores in diagnosing birth asphyxia with the gold standard, and identified healthcare provider factors that affect the ineffective use of APGAR scores. The results showed that APGAR scores had low sensitivity and positive predictive values. Healthcare provider factors associated with ineffective use of APGAR scores included instrumental delivery, lack of access to APGAR scoring charts, and neonatal resuscitation.
Article
Pediatrics
Nigusie Selomon Tibebu, Tigabu Desie Emiru, Chalie Marew Tiruneh, Bisrat Dessie Getu, Moges Wubneh Abate, Adane Birhanu Nigat, Berihun Bantie, Getasew Legas, Belete Gelaw Walle, Mulualem Gete Feleke, Endalk Birrie
Summary: Birth asphyxia is a major cause of neonatal death worldwide, particularly in developing nations like Ethiopia. This study aimed to determine the magnitude of birth asphyxia and its contributing factors among neonates delivered at a hospital in north-central Ethiopia. The results showed that the gender of the newborn, antenatal care visits, and history of poor pregnancy outcomes were significant risk factors for birth asphyxia.
Article
Physiology
Helen B. Stolp, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Sebastian Birtles, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Nicola J. Robertson, Ingran Lingam, Christopher Meehan, Kathryn A. Martinello, Adnan Avdic-Belltheus, Liane Stein, Mohamed Tachrount, David Price, Magdalena Sokolska, Alan Bainbridge, Mariya Hristova, Bobbi Fleiss, Boris W. Kramer, Pierre Gressens, Xavier Golay
SCIENTIFIC REPORTS
(2020)
Article
Pediatrics
Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Kathryn Martinello, Sara Ragab, Donald Peebles, Melinda Barkhuizen, Cally J. Tann, Ilias Tachtsidis, Tim G. A. M. Wolfs, Henrik Hagberg, Nigel Klein, Bobbi Fleiss, Pierre Gressens, Xavier Golay, Boris W. Kramer, Nicola J. Robertson
Summary: In this study, mRNA and miRNA were found to play a crucial role in differentiating hypoxia from inflammation-sensitized hypoxia in neonatal encephalopathy. Early detection of mRNA levels and specific miRNAs could potentially lead to tailored neuroprotection strategies for infants with NE.
PEDIATRIC RESEARCH
(2021)
Review
Clinical Neurology
Bobbi Fleiss, Pierre Gressens, Helen B. Stolp
FRONTIERS IN NEUROLOGY
(2020)
Review
Clinical Neurology
Emily Ross-Munro, Faith Kwa, Jenny Kreiner, Madhavi Khore, Suzanne L. Miller, Mary Tolcos, Bobbi Fleiss, David W. Walker
FRONTIERS IN NEUROLOGY
(2020)
Review
Biochemistry & Molecular Biology
Syam Nair, Eridan Rocha-Ferreira, Bobbi Fleiss, Cora H. Nijboer, Pierre Gressens, Carina Mallard, Henrik Hagberg
Summary: Mesenchymal stem cells have a positive effect in perinatal brain injury, potentially due to their immunomodulatory and mitoprotective effects. Challenges remain for effective clinical translation of this therapy.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Bobbi Fleiss, Juliette Van Steenwinckel, Cindy Bokobza, Isabelle K. Shearer, Emily Ross-Munro, Pierre Gressens
Summary: Perinatal brain injuries, including a range of disorders, can lead to permanent neurodevelopmental deficits through cellular and molecular cascades. Microglia play a crucial role in both brain building and responding to brain injury, as well as in the transduction of systemic inflammation into neuroinflammation. Modulating microglia may be a key strategy for neuroprotection in perinatal brain injuries.
Review
Pharmacology & Pharmacy
Sofia Passera, Marta Boccazzi, Cindy Bokobza, Valerie Faivre, Fabio Mosca, Juliette Van Steenwinckel, Monica Fumagalli, Pierre Gressens, Bobbi Fleiss
Summary: Acquired perinatal brain injuries present a significant challenge for healthcare providers and have broad social, emotional, and financial implications. Stem cell therapy shows promise in reducing perinatal brain injury, but there is a lack of focused trials on treating brain injuries in preterm born infants. Standardizing stem cell products and testing them across various injury models could help in the development of effective clinical trials.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pediatrics
Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Tatenda Mutshiya, Qin Yang, Mustafa Ali Akin, David Price, Magdalena Sokolska, Alan Bainbridge, Mariya Hristova, Ilias Tachtsidis, Cally J. Tann, Donald Peebles, Henrik Hagberg, Tim G. A. M. Wolfs, Nigel Klein, Boris W. Kramer, Bobbi Fleiss, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Therapeutic hypothermia did not show protection in a piglet model of inflammation-sensitized hypoxia-ischemia, as evidenced by aEEG, MRS, and immunohistochemistry. The immunosuppressive effects of hypothermia and the counteracting neuroinflammation by LPS may have led to the lack of efficacy of hypothermia in this context. Other immunomodulatory strategies may be more effective in treating inflammation-sensitized hypoxia-ischemia injuries.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Clinical Neurology
Bobbi Fleiss, Deidre M. Murray, S. Tracey Bjorkman, Julie A. Wixey
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Cindy Bokobza, Pooja Joshi, Anne-Laure Schang, Zsolt Csaba, Valerie Faivre, Amelie Montane, Anne Galland, Anouk Benmamar-Badel, Emmanuelle Bosher, Sophie Lebon, Leslie Schwendimann, Shyamala Mani, Pascal Dournaud, Valerie Besson, Bobbi Fleiss, Pierre Gressens, Juliette Van Steenwinckel
Summary: The study highlights the importance of miRNA-146b-5p in regulating microglial activation and white matter injury, which could be targeted to prevent and treat perinatal brain injuries effectively.
ANNALS OF NEUROLOGY
(2022)
Article
Environmental Sciences
Leslie Schwendimann, Iswariya Sivaprakasam, Sriramulu Buvaneshwari, Gundiga P. Gurumurthy, Saumya Mishra, Laurent Ruiz, Muddu Sekhar, Bobbi Fleiss, Jean Riotte, Shyamala Mani, Pierre Gressens
Summary: Pregnant and lactating mice given agricultural water in intensely cultivated land resulted in abnormal brain development in offspring, with neurodevelopmental issues such as neuronal degeneration, loss of astrocytes, increased microglial cells, and cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Luisa Klein, Juliette Van Steenwinckel, Bobbi Fleiss, Till Scheuer, Christoph Buehrer, Valerie Faivre, Cindy Bokobza, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Zsolt Csaba, Dulcie A. Vousden, Jason P. Lerch, Anthony C. Vernon, Pierre Gressens, Thomas Schmitz
Summary: Preterm infants often exhibit cerebellar pathologies, which are associated with motor impairments, lower IQ, and poor language skills. This study used a mouse model to investigate the causes of cerebellar damage in inflammation-induced encephalopathy of prematurity. The results suggest that the systemic administration of IL-1 beta leads to specific reductions in cerebellar gray and white matter volumes, likely due to oligodendrocyte pathology downstream of microglial activation. These findings highlight the importance of identifying protective strategies targeting cerebellar microglia activation and sustained type I interferon signaling.
Article
Pediatrics
Olga Romantsik, Emily Ross-Munro, Susanne Gronlund, Bo Holmqvist, Anders Brinte, Erik Gerdtsson, Suvi Vallius, Matteo Bruschettini, Xiaoyang Wang, Bobbi Fleiss, David Ley
Summary: This study examines the long-term effects of severe intraventricular hemorrhage on rabbit brains using a preterm animal model. The findings reveal significant alterations to cortical organization and microstructure, providing important insights for therapy design and interventions.
PEDIATRIC RESEARCH
(2022)
Article
Neuroimaging
Lisa Story, Alice Davidson, Prachi Patkee, Bobbi Fleiss, Vanessa Kyriakopoulou, Kathleen Colford, Srividhya Sankaran, Paul Seed, Alice Jones, Jana Hutter, Andrew Shennan, Mary Rutherford
Summary: This study compared MRI derived regional brain volumes in fetuses that deliver < 32 weeks with fetuses that subsequently deliver at term, finding a reduction in cortical and eCSF volumes in fetuses that deliver preterm.
NEUROIMAGE-CLINICAL
(2021)