Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

Compartmentation of cAMP signalling in cardiomyocytes in health and disease

(2013) R. K. Perera et al.   Acta Physiologica

PDE4 in the human heart - major player or little helper?

(2013) Thomas Eschenhagen   BRITISH JOURNAL OF PHARMACOLOGY

PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

(2013) Peter Molenaar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

(2012) Cristina E. Molina et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphodiesterases reduce spontaneous sinoatrial beating but not the ‘fight or flight’ tachycardia elicited by agonists through Gs-protein-coupled receptors

(2011) Alberto J. Kaumann   TRENDS IN PHARMACOLOGICAL SCIENCES

Conserved expression and functions of PDE4 in rodent and human heart

(2010) Wito Richter et al.   BASIC RESEARCH IN CARDIOLOGY

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Arrhythmogenic Effects of β 2 -Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load

(2008) Jaime DeSantiago et al.   CIRCULATION RESEARCH

Combination Therapy with β-Adrenergic Receptor Antagonists and Phosphodiesterase Inhibitors for Chronic Heart Failure

(2008) Benjamin W Van Tassell et al.   PHARMACOTHERAPY

Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)-adrenaline mediated through mouse cardiac β1-adrenoceptors

(2007) A Galindo-Tovar et al.   BRITISH JOURNAL OF PHARMACOLOGY