Review
Biotechnology & Applied Microbiology
Andrzej M. Woyda-Ploszczyca, Andrzej S. Rybak
Summary: Algae have been extensively researched for their potential applications, with a focus on microalgae like Dunaliella. These organisms accumulate valuable components under stress conditions and efficient nucleotide metabolism is crucial for their rapid growth. Understanding the biochemical nature of Dunaliella can optimize cultivation methods, increase biomass production, conserve resources, and potentially aid in treating various diseases.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Pharmacology & Pharmacy
Facundo Galceran, Fabio A. Digirolamo, Marcos Rengifo, Chantal Reigada, Melisa Saye, Belen J. Maciel, Ivana G. Estecho, Andrea E. Errasti, Claudio A. Pereira, Mariana R. Miranda
Summary: In this study, potential drugs for the treatment of Chagas' disease were identified using computer-assisted drug repurposing methods. NEB and TEL showed inhibitory effects on the causative agent of Chagas' disease and performed comparably to the first-line drug BZL.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Danye Qiu, Chunfang Gu, Guizhen Liu, Kevin Ritter, Verena B. Eisenbeis, Tamara Bittner, Artiom Gruzdev, Lea Seidel, Bertram Bengsch, Stephen B. Shears, Henning J. Jessen
Summary: This study used capillary electrophoresis mass spectrometry to investigate the levels of InsPs and PP-InsPs in mouse tissues. The results showed unusually high levels of InsPs and PP-InsPs in the mouse colon, and the PP-InsP profile was more complex than previously reported. Additionally, the study found that these molecules were not only present in the colon, but also in the heart and blood cells.
Article
Plant Sciences
Leszek A. Kleczkowski, Abir U. Igamberdiev
Summary: Free magnesium ions serve as a powerful signal derived from the interconversion of adenylates. Adenylate kinase (AK) plays a role in equilibrating adenylates and using specific forms of Mg-complexed and Mg-free adenylates. In addition, other reversible Mg2+-dependent enzymes equilibrate non-adenylate nucleotides. AK activity is closely linked to the activities of these enzymes, establishing main hubs for equilibration of non-adenylate nucleotides with Mg2+ controlling the ratios of Mg-chelated and Mg-free nucleotides. This coupling has consequences for various cellular pathways and nucleotide availability for RNA and DNA synthesis.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hua Li, Lulu Chen, Hongyu Chen, Ruili Xue, Yuexia Wang, Jianbo Song
Summary: This review summarizes the regulatory functions of progesterone on plant growth and development, as well as its response to stress. The paper also discusses the plant metabolic processes of progesterone. Progesterone is ubiquitous in plants and can regulate numerous plant physiological processes at low concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nidhi Pamidimukkala, Gemma S. Puts, M. Kathryn Leonard, Devin Snyder, Sandrine Dabernat, Edward C. De Fabo, Frances P. Noonan, Andrzej Slominski, Glenn Merlino, David M. Kaetzel
Summary: NME1 and NME2 genes have a significant impact on metastatic activity in a mouse model of melanoma, with NME2 showing MSG activity for the first time in a spontaneous cancer model, and NME1 displaying a novel metastasis-suppressor function in UVR-induced melanoma.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Celine Prunier, Philippe Chavrier, Mathieu Boissan
Summary: Metastatic progression is regulated by metastasis promoter and suppressor genes. NME1, NME2, and NME4 are reported as metastasis suppressors, and they interact with members of the GTPase dynamin family to control membrane fission and fusion reactions. NME1 and NME2 provide GTP to dynamins at the plasma membrane, driving endocytosis and attenuating signaling, while NME4 interacts with dynamin OPA1 at the mitochondria inner membrane to promote inner membrane fusion and maintain a fused mitochondrial network. These functions of NME family members are closely linked to metastasis and provide insights into the metastasis suppressor role of NME proteins.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Nguyen, Blagojce Jovcevski, Tara L. Pukala, John B. Bruning
Summary: Aspergillus fumigatus infections and antifungal resistance rates are increasing. Limited understanding of the biological and structural mechanisms of A. fumigatus propagation hinders the development of novel antifungals. Research reveals nucleoside selectivity in NDK of A. fumigatus, where adenine nucleosides are preferred over cytidine nucleosides, providing insights for drug design.
Article
Biochemistry & Molecular Biology
Shashanka K. Prasad, Smitha S. Bhat, Olga Koskowska, Jiraporn Sangta, Sheikh F. Ahmad, Ahmed Nadeem, Sarana Rose Sommano
Summary: A study found that a phytochemical in coffee pulp called Naringin showed strong antifungal activity against the foodborne fungus Aspergillus fumigatus. Naringin was also shown to have good oral bioavailability. Toxicity predictions indicated that Naringin is safe for human consumption and could be used to develop antifungal treatments and food packaging materials. This study addresses the issues of coffee waste management and antifungal resistance.
Article
Chemistry, Multidisciplinary
Yuqin Wang, Pingping Fan, Shanyu Zhang, Liying Wang, Xinyue Li, Wendong Jia, Yao Liu, Kefan Wang, Xiaoyu Du, Panke Zhang, Shuo Huang
Summary: In this study, a specially engineered nanopore sensor was used to successfully discriminate all canonical ribonucleoside mono-, di-, and triphosphates, and a machine-learning algorithm was developed with a general accuracy of 99.9% for ribonucleotide sensing. This sensing strategy was also applied to identify ribonucleotide components in different phosphorylated forms.
Review
Plant Sciences
Kai Hao, Yun Wang, Zhanpin Zhu, Yu Wu, Ruibing Chen, Lei Zhang
Summary: This review summarizes the recent progress on the contributions of the miR160-ARF module to important traits of plants and the role of miR160-centered gene regulatory network in coordinating growth with endogenous and environmental factors. Manipulation of miR160-guided gene regulation may provide a new method to engineer plants with improved adaptability and yield.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Parasitology
Mariana R. Miranda, Melisa Saye, Chantal Reigada, Facundo Galceran, Marcos Rengifo, Belen J. Maciel, Fabio A. Digirolamo, Claudio A. Pereira
Summary: NDPKs have been identified as key metabolic enzymes across all organisms, maintaining nucleoside homeostasis and playing diverse roles in gene regulation, apoptosis, signal transduction, and more. Research has shown that trypanosomatid NDPKs have unique functions compared to their hosts, potentially making them attractive pharmacological targets for parasite biology and immune evasion.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2021)
Article
Biochemistry & Molecular Biology
Ana Isabel Gonzalez-Hernandez, Loredana Scalschi, Begonya Vicedo, Emilio Luis Marcos-Barbero, Rosa Morcuende, Gemma Camanes
Summary: Putrescine is the starting point of the polyamines pathway and plays a crucial role in plant growth and development, as well as tolerance responses to stresses. Various research methods, including competitive inhibitors, exogenous Putrescine treatment, and mutant and transgenic plants, have been used to investigate its involvement in plant systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Leszek A. Kleczkowski, Abir U. Igamberdiev
Summary: Free magnesium (Mg2+) functions as a signal of adenylate (ATP+ADP+AMP) status in cells, controlled by the equilibrium of adenylate kinase (AK) and membrane-bound adenylate- and Mg2+-translocators. Changes in [Mg2+] impact enzyme activities, metabolism, and processes like photosynthesis, under normal and stress conditions. Magnesium signaling is likely widespread in all eukaryotic and prokaryotic organisms due to the ubiquitous nature of AK and its role in adenylate equilibration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Cristina Andres-Barrao, Hanin Alzubaidy, Rewaa Jalal, Kiruthiga G. Mariappan, Axel de Zelicourt, Ameerah Bokhari, Olga Artyukh, Khairiah Alwutayd, Anamika Rawat, Kirti Shekhawat, Marilia Almeida-Trapp, Maged M. Saad, Heribert Hirt
Summary: Enterobacter sp. SA187, a root endophytic bacterium, plays a crucial role in enhancing salt stress tolerance in plants by modulating the sulfur metabolic pathways. SA187 partially rescues the deficiency of sulfur metabolism components in the chloroplast, positively impacting the plant's response to salt stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Yang Liu, Valentin Joly, Sonia Dorion, Jean Rivoal, Daniel P. Matton
JOURNAL OF PROTEOME RESEARCH
(2015)
Article
Biochemical Research Methods
Evgenia L. Auslender, Sonia Dorion, Sebastien Dumont, Jean Rivoal
PROTEIN EXPRESSION AND PURIFICATION
(2015)
Article
Plant Sciences
Sebastien Dumont, Natalia V. Bykova, Guillaume Pelletier, Sonia Dorion, Jean Rivoal
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Plant Sciences
Sonia Dorion, Audrey Clendenning, Jean Rivoal
Article
Biochemistry & Molecular Biology
M. A. Troncoso-Ponce, J. Rivoal, S. Dorion, R. Sanchez, M. Venegas-Caleron, A. J. Moreno-Perez, S. Baud, R. Garces, E. Martinez-Force
Article
Multidisciplinary Sciences
Sebastien Dumont, Natalia Bykova, Alexia Khaou, Yasmine Besserour, Maude Dorval, Jean Rivoal
Article
Plant Sciences
Jiang Zhou He, Sonia Dorion, Melanie Lacroix, Jean Rivoal
Review
Plant Sciences
Sebastien Dumont, Jean Rivoal
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Environmental Sciences
Carl Bowazolo, Sirius P. K. Tse, Mathieu Beauchemin, Samuel C. -L. Lo, Jean Rivoal, David Morse
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Review
Biochemistry & Molecular Biology
Sonia Dorion, Jasmine C. Ouellet, Jean Rivoal
Summary: Glutathione plays a crucial role in plant life by controlling reactive oxygen species and detoxifying methylglyoxal. Oxidative stress can lead to covalent modification of proteins by glutathione, affecting their function and adaptation to stress.
Article
Biotechnology & Applied Microbiology
Erika Juliana Obando Montoya, Sonia Dorion, Lucia Atehortua-Garces, Jean Rivoal
Summary: Phycobiliproteins are colored and active molecules with potential industrial uses, primarily sourced from algae. Research on production in bacterial models is seen as a more efficient alternative due to traditional algae culture restrictions. This study focused on characterizing enzymes involved in chromophore production using Porphyridium cruentum protein sequences as a basis.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Carl Bowazoloa, Bo Songb, Sonia Doriona, Mathieu Beauchemina, Samuel Chevriera, Jean Rivoala, David Morsea
Summary: Ribosome profiling in the dinoflagellate Lingulodinium polyedra reveals coordinated translation of thousands of transcripts, indicating rhythms in carbon fixation, DNA replication, glycolysis, the TCA cycle, and amino acid biosynthesis. The findings suggest that ribosome profiling may provide a more accurate prediction of metabolic changes compared to transcriptomics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Diljot Kaur, Sonia Dorion, Souleimen Jmii, Laurent Cappadocia, Jacqueline C. Bede, Jean Rivoal
Summary: Jasmonates play a critical role in plant resistance against pathogens and herbivores. The biosynthesis of jasmonates involves the catalytic activity of iron lipoxygenases, specifically AtLOX2 in Arabidopsis thaliana. The phosphorylation of Ser600 in AtLOX2 inhibits enzyme activity, while a mutant with abnormal phosphorylation exhibits strong activity. This suggests that Ser600 phosphorylation may regulate AtLOX2 activity and, consequently, the jasmonate biosynthesis pathway and plant resistance.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
S. Dorion, J. Rivoal
PLANT SIGNALING & BEHAVIOR
(2018)