Article
Endocrinology & Metabolism
Aliance Romain Fokoua, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Rodolphe Chouna, Oluwabusayo Folarin, James Olopade, Pepin Alango Nkeng-Efouet, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Telesphore Benoit Nguelefack
Summary: The study demonstrated the potential antiepileptic activity of Psychotria camptopus on drug-resistant epilepsy, likely through enhancing antioxidant and neuroprotective mechanisms.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Ane Gabriela Vogt, Renata Leivas de Oliveira, Guilherme Teixeira Voss, Gustavo Bierhals Blodorn, Diego Alves, Ethel Antunes Wilhelm, Cristiane Luchese
Summary: The present study evaluated the protective effect of a compound QTCA-1 on seizure severity and memory disorder in a mouse model of epileptogenesis. The results showed that QTCA-1 significantly decreased seizure severity and protected against memory impairment induced by seizures. The compound also normalized oxidative stress and Na+/K+-ATPase activity in the brain structures of the mice. These findings suggest that QTCA-1 holds promise as a potential treatment for epilepsy and associated comorbidities.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Nouf M. Alyami, Saba Abdi, Hanadi M. Alyami, Rafa Almeer
Summary: This study found that proanthocyanidins can alleviate oxidative stress, neuroinflammation, and neuronal apoptosis in PTZ-induced seizures in mice by activating the Nrf2 signaling pathway.
NEUROCHEMICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Fatemeh Sadat Heydari, Mahmoud Gorji Valokola, Soghra Mehri, Khalil Abnous, Ali Roohbakhsh
Summary: This study investigated the role of TRPA1 in the treatment of epilepsy and found that the TRPA1 antagonist HC030031 can reduce the severity of seizures and prevent the upregulation of TRPA1 levels after seizure induction.
METABOLIC BRAIN DISEASE
(2023)
Article
Andrology
Fatma Bedia Karakaya, Melis Yavuz, Serap Sirvanci
Summary: This study aimed to investigate the protective effects of thymoquinone on testicular damage in an epilepsy model. It was found that PTZ-induced epileptic seizures caused degeneration of seminiferous tubules in rats, while thymoquinone administration could ameliorate this damage by decreasing apoptosis and increasing proliferation in testicular cells.
Review
Endocrinology & Metabolism
Tanveer Singh, Awanish Mishra, Rajesh Kumar Goel
Summary: PTZ-induced seizure in mice is a valuable model for evaluating novel anticonvulsants and studying epilepsy mechanisms, treatment methods, and associated comorbidities.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Mozhdeh Radpour, Samira Choopani, Hamid Gholami Pourbadie, Mohammad Sayyah
Summary: Toll-like receptor 4 (TLR4) signaling has a detrimental role in traumatic brain injury (TBI) pathology. However, TLR4 priming can alleviate TBI inflammation and seizure susceptibility. In this study, we found that postconditioning with TLR4 agonist monophosphoryl lipid A (MPL) reduces TBI neuroinflammation and epileptogenesis by decreasing neural death and inflammation, while upregulating anti-inflammatory cytokines.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Leticia Lazzarotto, Pricila Pfluger, Gabriela Gregory Regner, Fernanda Marcelia Santos, Debora Goncalves Aguirre, Veronica Bidinotto Brito, Dinara Jaqueline Moura, Nayane Mendes dos Santos, Jaqueline Nascimento Picada, Belisa Parmeggiani, Marina Rocha Frusciante, Guilhian Leipnitz, Patricia Pereira
Summary: This study evaluated the effects of lacosamide on biochemical and mitochondrial parameters after PTZ kindling in mice. Lacosamide showed positive effects on reducing free radicals, improving mitochondrial enzymatic activity, and protecting against oxidative stress and DNA damage induced by repeated PTZ administration.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Immunology
Zahra Tavakoli, Hossein Tahmasebi Dehkordi, Zahra Lorigooini, Mohammad Rahimi-Madiseh, Mehrdad Shahrani Korani, Hossein Amini-Khoei
Summary: This study aimed to evaluate the effect of quercetin on PTZ-induced seizures in mice and focus on its potential anti-neuroinflammatory and anti-oxidative stress properties. The results showed that quercetin increased the seizure threshold, enhanced total antioxidant capacity, and reduced levels of malondialdehyde as well as the expression of inflammatory genes in the prefrontal cortex.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi
Summary: Fisetin has been found to improve cognitive function in mice with PTZ-induced kindling through modulation of oxidative stress markers, gene expressions, and neurotransmitter levels. These findings suggest a therapeutic potential of fisetin against cognitive dysfunction associated with PTZ-induced kindling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Md Hussain, Haroon Rashid, Jatinder Katyal
Summary: This study evaluated the effects of the antidepressant sertraline in combination with AEDs sodium valproate and levetiracetam on seizures, cognitive impairment, and oxidative stress in rats. Results showed that SV provided 100% protection against kindling, while SRT had no protective effect. Combining LEV with SRT was effective in reducing cognitive impairment and oxidative stress in PTZ kindled rats.
Article
Biochemistry & Molecular Biology
Aurelien Fossueh Foutsop, Gilbert Ateufack, Blesdel Maxwell Adassi, Francis Bray Yassi, Tatiana Diebo Kom, Chretien Mbeugangkeng Noungoua, Adolph Petsou, Gwladys Temkou Ngoupaye
Summary: The study evaluated the antiepileptogenic and antiepileptic effects of Alchemilla kiwuensis in a PTZ-induced kindling model and assessed its sub-chronic toxicity. The results showed that A. kiwuensis delayed seizure appearance, reduced seizure repetition and duration, and had positive effects on biochemical markers. These findings suggest that A. kiwuensis has antiepileptic and antiepileptogenic effects and is safe in a sub-chronic model.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Md. Niyaz Alam, Lubhan Singh, Najam Ali Khan, Yahya I. Asiri, Mohd. Zaheen Hassan, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Md. Sarfaraj Hussain
Summary: This study investigated the pharmacological effects of ethanolic extract of M. oleifera leaves and curcumin against epilepsy. The results showed that they had certain effects in alleviating seizures, improving cognitive impairment, and reducing oxidative stress. The combination of M. oleifera and curcumin had better anti-epileptic effects compared to other combinations.
Article
Behavioral Sciences
Gagandeep Jaiswal, Puneet Kumar
Summary: This study investigated the neuroprotective effect of the NADPH oxidase inhibitor apocynin in pentylenetetrazole-induced epilepsy and related comorbidities. The results demonstrated that apocynin significantly reduced seizure severity, oxidative stress, neurotransmitter alterations, and comorbid conditions in mice.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Ozlem Ergul Erkec, Oruc Yunusoglu, Zubeyir Huyut
Summary: This study investigated the effects of repeated ghrelin treatment on seizure scores, working memory, locomotor activity, oxidative biomarkers, and neurochemical parameters in a PTZ kindling model in rats. The results showed that repeated ghrelin treatment had antioxidant and anticonvulsant activity.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
