Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Geriatrics & Gerontology
Simone de Vries Lentsch, Eloisa Rubio-Beltran, Antoinette MaassenVanDenBrink
Summary: Migraine is a neurovascular disorder more prevalent in women, driving the urgent need for new preventive medications. Current research targeting CGRP has shown significant effects in clinical trials for prevention and acute treatment of migraine. Further exploration is needed to understand the potential gender-specific differences in CGRP response and potential cardiovascular risks associated with targeting the CGRP pathway in female migraine patients.
Review
Pharmacology & Pharmacy
Farzin Zobdeh, Aziza Ben Kraiem, Misty M. Attwood, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioth, Jessica Mwinyi
Summary: Migraine is a prevalent disease globally and limited therapy response requires individually adjusted treatment. The pharmaceutical development for acute and chronic migraine has significantly intensified in recent years, with an expansion of drug targets and increased number of clinical trials.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Krishna P. Naduchamy, Varadarajan Parthasarathy
Summary: This review provides an insight into the various target proteins involved in migraine headaches, with a focus on the importance of the CGRP receptor in migraine development. Inhibiting this receptor may be an effective way to treat migraine headaches. Research suggests that targeting the CGRP receptor for novel molecule development to treat migraine headaches is a key focus for researchers worldwide.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lars Edvinsson, Kristian Agmund Haanes
Summary: Primary headaches, with migraines being the most common type, are believed to be influenced by a mismatch in the trigeminovascular system, resulting in sensitization and the release of CGRP. The research focuses on how to modify this system for future treatments by understanding the distribution and expression of neuropeptides and ion channels.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Matilde Capi, Valerio De Angelis, Donatella De Bernardini, Ottavia De Luca, Fabiola Cipolla, Luana Lionetto, Maurizio Simmaco, Paolo Martelletti
Summary: The discovery of CGRP's role in migraine pathophysiology has led to the development of new drugs, showing potential to transform migraine management, although its exact position is yet to be determined.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. M. Villalon
Summary: 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter in various nervous system functions. Its actions are complex and depend on multiple factors, including the type of effector or receptor activated. This review summarizes and discusses the impact of 5-HT on blood pressure regulation and vascular-related diseases.
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Carlos M. Villalon
Summary: Monoclonal antibodies act as prophylactic antimigraine agents by targeting CGRP or its receptors, revolutionizing the treatment of this disorder. Despite their long half-lives and hepato-friendly properties, potential cardiovascular side effects and immunogenicity induced by autoantibodies against mAbs present safety concerns for long-term use.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Miguel Condes-Lara, Enrique Garcia-Boll, Carlos M. Villalon
Summary: Neuropeptides play an important role in migraine pathophysiology, with molecules such as CGRP, PACAP, OT, and orexins showing potential as novel targets for treatment. However, targeting these neuropeptide systems may lead to both antimigraine effects and potential side effects due to their complex intracellular mechanisms. Pharmacokinetics issues may also limit the use of molecules targeting neuropeptidergic transmission.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Clinical Neurology
Adisa Kuburas, Andrew F. Russo
Summary: The neuropeptides CGRP and PACAP play important roles in migraine pathogenesis by causing vasodilation and migraine-like symptoms. They have similarities in their clinical and preclinical actions, but also notable differences, such as PACAP causing premonitory-like symptoms and CGRP and PACAP being found in different ganglia. Both peptides cause similar migraine-like symptoms in rodents, but may act through independent mechanisms. The existence of multiple receptors for CGRP and PACAP further complicates the signaling pathways involved, suggesting that targeting PACAP receptors could complement current CGRP-based migraine therapeutics.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Iris E. Verhagen, Simone de Vries Lentsch, Britt W. H. van Der Arend, Saskia le Cessie, Antoinette MaassenVanDenBrink, Gisela M. Terwindt
Summary: This study compared the treatment effect on perimenstrual and nonperimenstrual migraine days and found that anti-CGRP antibodies have a similar reduction effect on both types of migraine days.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Critical Care Medicine
Saul Huerta de la Cruz, Luisa Rocha, Cindy Santiago-Castaneda, Araceli Sanchez-Lopez, Alma D. Pinedo-Rodriguez, Grecia J. Medina-Terol, David Centurion
Summary: The study showed that subchronic administration of NaHS could prevent the development of cardiovascular and sympathetic system impairments after TBI, while having no significant effects on sensorimotor dysfunction.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Pharmacology & Pharmacy
Erick Josue Rodriguez-Palma, Dania Guadalupe Castelo-Flores, Nadia Lizeth Caram-Salas, Ana Belen Salinas-Abarca, David Centurion, Yarim Elideth De la Luz-Cuellar, Vinicio Granados-Soto
Summary: Tizanidine exhibits a sex-dependent antiallodynic effect in neuropathic rats, with stronger effect in females. The antiallodynic effect of tizanidine is influenced by ovariectomy and naloxone, and is associated with the activation of adrenergic and opioid receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Ashline Paul Manoucheca Amilcar, Lorena Rosas-Martinez, Juan Carlos Torres-Narvaez, Araceli Sanchez-Lopez, Luz Graciela Cervantes-Perez, David Centurion, Alicia Sanchez-Mendoza
Meeting Abstract
Biochemistry & Molecular Biology
Martin C. Michel, Jesus H. Beltrans-Ornelas, Diana L. Silva-Velasco, Tamara R. Castaneda, Ralf Elvert, Aimo Kannt, Ning Xia, Huige Li, Ebru Arioglu-Inan, David Centurion
Article
Endocrinology & Metabolism
Saul Huerta de la Cruz, Erick J. Rodriguez-Palma, Cindy L. Santiago-Castaneda, Jesus H. Beltran-Ornelas, Araceli Sanchez-Lopez, Luisa Rocha, David Centurion
Summary: This study aimed to evaluate the effect of NaHS subchronic treatment on the changes of H2S-synthesizing enzymes in the hypothalamus and brainstem after TBI. The results showed that NaHS had an effect on CBS and CSE protein expression, suggesting a potential role in the impairments observed after TBI.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Saul Huerta de la Cruz, Grecia J. Medina-Terol, Araceli Sanchez-Lopez, David Centurion
Summary: This study found that hydrogen sulfide can increase vasodilation induced by non-adrenergic/non-cholinergic (NANC) outflow by activating TRPA1 channels.
Article
Physiology
Zeynep E. Yesilyurt, Jan Matthes, Edith Hintermann, Tamara R. Castaneda, Ralf Elvert, Jesus H. Beltran-Ornelas, Diana L. Silva-Velasco, Ning Xia, Aimo Kannt, Urs Christen, David Centurion, Huige Li, Andrea Pautz, Ebru Arioglu-Inan, Martin C. Michel
Summary: This study explores the relationship between bladder enlargement and diabetes in rodent models, finding significant variations in bladder enlargement across different models, particularly in type 2 diabetes models. The study concludes that bladder enlargement is not primarily driven by glucose levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Grecia J. Medina-Terol, Saul Huerta de la Cruz, Jesus H. Beltran-Ornelas, Araceli Sanchez-Lopez, David Centurion
Summary: This study evaluated the role of potassium channels in the sympathoinhibition induced by hydrogen sulfide (H2S). The results showed that the sympathoinhibition was not dependent on sex and was mediated by the activation of multiple potassium channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Erika J. Gutierrez-Lara, Araceli Sanchez-Lopez, Janet Murbartian, Selene J. Acosta-Cota, David Centurion
Summary: Several studies have shown that insulin resistance (IR) is related to the development of diseases like diabetes mellitus, hypertension, metabolic syndrome, and polycystic ovary syndrome. Dysfunction of female gonadal hormones, especially 17 beta-estradiol, may contribute to the development of complications in IR. This study aimed to investigate the effects of 17 beta-estradiol administration in insulin-resistant rats and its impact on cardiovascular responses in pithed rats.
Article
Pharmacology & Pharmacy
Saul Huerta de la Cruz, Grecia J. Medina-Terol, Jorge A. Tapia-Martinez, Diana L. Silva-Velasco, Jesus H. Beltran-Ornelas, Araceli Sanchez-Lopez, Maria Sancho, David Centurion
Summary: Hydrogen sulfide (H2S) is a gasotransmitter belonging to the family of gasotransmitters along with carbon monoxide and nitric oxide. It is endogenously produced through enzymatic and non-enzymatic pathways. H2S acts as a regulator in various physiological functions, particularly in the cardiovascular system where it influences vascular tone. It modulates the activity of vascular smooth muscle cells, endothelial cells, and perivascular nerves, and can attenuate the increased activity of the sympathetic nervous system in certain pathological conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Felix I. Lopez-Preza, Saul Huerta de la Cruz, Cindy Santiago-Castaneda, Diana L. Silva-Velasco, Jesus H. Beltran-Ornelas, Jorge Tapia-Martinez, Araceli Sanchez-Lopez, Luisa Rocha, David Centurion
Summary: This study aimed to assess the effects of subchronic administration with NaHS on TBI-induced hypertension and vascular impairments. The results showed that NaHS prevented the development of hypertension, vascular dysfunction, and oxidative stress, and restored H2S-synthesizing enzymes and eNOS phosphorylation. However, NaHS had no effect on body weight, sensorimotor impairments, or brain water content.
Article
Biochemistry & Molecular Biology
Saul Huerta de la Cruz, Cindy L. Santiago-Castaneda, Erick J. Rodriguez-Palma, Grecia J. Medina-Terol, Felix Lopez-Preza, Luisa Rocha, Araceli Sanchez-Lopez, Kalev Freeman, David Centurion
Summary: The systemic cardiovascular effects of major trauma, especially neurotrauma, contribute to death and permanent disability in trauma patients. Dysfunction of the autonomic nervous system and activation of innate immune responses play a role in producing secondary cardiovascular injury. Gasotransmitters NO and H2S have potential therapeutic benefits in restoring cardio-cerebrovascular function in trauma patients.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Deborah N. Kalkman, Emile G. M. Couturier, Abdelhak El Bouziani, Jorge Dahdal, Jolien Neefs, Janneke Woudstra, Birgit Vogel, Daniela Trabattoni, Antoinette MaassenVanDenBrink, Roxana Mehran, Robbert J. de Winter, Yolande Appelman
Summary: Migraine is a chronic neurovascular disease with complex pathophysiology and multiple causes. Women are more likely to suffer from migraine, and it is the most disabling disease in women under 50 years old. Migraine with aura is associated with increased risk of cardiovascular diseases, such as stroke, atrial fibrillation, myocardial infarction, and cardiovascular death. Medications for migraine treatment may have potential risks for patients with cardiovascular disease. Further research is needed to understand the contraindications for newer treatments. This review discusses the pathophysiology, associations with cardiovascular diseases, current therapies, and future research directions.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Diana L. Silva-Velasco, Jesus H. Beltran-Ornelas, Jorge Tapia-Martinez, Araceli Sanchez-Lopez, Saul Huerta de la Cruz, Luz Graciela Cervantes-Perez, Leonardo del Valle-Mondragon, Alicia Sanchez-Mendoza, David Centurion
Summary: Hyperglycemia impairs the renin-angiotensin system, but hydrogen sulfide has beneficial cardiovascular effects. The study aimed to determine the effects of chronic administration of hydrogen sulfide and a cystathionine-gamma-lyase inhibitor on vascular responses in diabetic rats. The results showed that hydrogen sulfide restores vascular function in streptozotocin-induced hyperglycemia through modulation of the renin-angiotensin system.
Review
Clinical Neurology
Dimos D. Mitsikostas, Christian Waeber, Margarita Sanchez-del-Rio, Bianca Raffaelli, Hakan Ashina, Antoinette Maassen van den Brink, Anna Andreou, Patricia Pozo-Rosich, Alan Rapoport, Messoud Ashina, Michael A. Moskowitz
Summary: Migraine, a leading cause of disability in over one billion people globally, is underestimated even by those who suffer from it. Current treatments have limited efficacy and potential side effects, resulting in low treatment adherence. Recently, a new class of drugs called ditans, selective serotonin 5-HT1F receptor agonists, has been introduced to the international market. This article reviews preclinical studies from the late 1990s and recent clinical research that led to the development and approval of ditans for acute migraine treatment by the US FDA and the European Medicines Agency.
NATURE REVIEWS NEUROLOGY
(2023)