Review
Medicine, General & Internal
Ivana Budic, Tatjana Jevtovic Stoimenov, Dimitrije Pavlovic, Vesna Marjanovic, Ivona Djordjevic, Marija Stevic, Dusica Simic
Summary: Individual variability in response to anesthesia drugs is common and influenced by genetic and environmental factors. Propofol, the most common intravenous anesthetic, can be affected by genetic factors such as gene polymorphisms. However, there is a need for further research on multiple pathways to understand the individual differences in propofol pharmacokinetics and pharmacodynamics.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Medicinal
Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi, Jung-Woo Bae
Summary: The study investigated the effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide. The results showed that CYP2C9 and CYP2C19 genetic polymorphisms significantly affected the pharmacokinetics of gliclazide. However, the effects on plasma glucose and insulin responses were not significant, suggesting further research is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Denise Turk, Laura Maria Fuhr, Fatima Zahra Marok, Simeon Rudesheim, Anna Kuhn, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Summary: Adverse drug reactions are a major cause of death and often linked to drug-gene interactions. Mathematical modeling can help understand and predict these interactions, leading to more efficient personalized dosing regimens. Collaboration between experts in different fields is crucial for the success of implementing and validating these models in clinical practice.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Rehabilitation
Gerasimos Bastas, Jonathan Dallas, Patricia Blair Miller, Nicole Kloosterman, Ion Yannopoulos
Summary: Most major limb amputation cases involve polypharmacy preoperatively and increased medication use or maintenance postoperatively. Drug-drug interaction warnings also increase, indicating the need for further research and clinical attention.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Pharmacology & Pharmacy
Boyu Fang, Shasha Jin, Wandi Du, Weimin Cai
Summary: A study has found that co-administration of vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) and anticoagulants increases the risk of bleeding. This raises concerns about the potential pharmacokinetic and pharmacodynamic interaction between TKIs and warfarin, which is used by tumor patients for DVT prevention.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Nicola Ferri, Elisa Colombo, Marco Tenconi, Ludovico Baldessin, Alberto Corsini
Summary: Direct oral anticoagulants (DOACs) are frequently prescribed to prevent ischemic stroke in non-valvular atrial fibrillation (NVAF) patients and treat venous thromboembolism (VTE). They have a favorable risk-benefit profile compared to warfarin but may increase the risk of gastrointestinal bleeding. Polypharmacy and comorbidity in elderly patients can lead to drug-drug interactions (DDIs) with DOACs. This review summarizes potential DDIs and discusses strategies to reduce their occurrence.
Review
Pharmacology & Pharmacy
Melisa Intan Barliana, Nadiya Nurul Afifah, Riezki Amalia, Laniyati Hamijoyo, Rizky Abdulah
Summary: SLE, a chronic autoimmune disease, is primarily influenced by genetic factors affecting treatment response. Research on gene polymorphisms impacting treatment is essential for advancing personalized medicine practices.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Article
Respiratory System
Nan Zhang, Radojka M. Savic, Martin J. Boeree, Charles A. Peloquin, Marc Weiner, Norbert Heinrich, Erin Bliven-Sizemore, Patrick P. J. Phillips, Michael Hoelscher, William Whitworth, Glenn Morlock, James Posey, Jason E. Stout, William Mac Kenzie, Robert Aarnoutse, Kelly E. Dooley
Summary: Pyrazinamide is a potent sterilizing agent that can shorten the treatment duration for tuberculosis, and its optimal dose remains uncertain. Higher blood concentrations of pyrazinamide are associated with faster culture conversion time and higher conversion probability. Optimizing the use of pyrazinamide may enhance its microbiologic efficacy, but increasing the dose alone may not be enough to shorten tuberculosis treatment, requiring parallel increases in rifampicin dose.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sukyong Yoon, Min Soo Park, Byung Hak Jin, Hyobin Shin, Jaejin Na, Wan Huh, Choon Ok Kim
Summary: This study evaluated the pharmacokinetic and pharmacodynamic interactions of DWP16001 and phentermine, and found that the combination therapy was similar to monotherapy in terms of PK and PD. The combination therapy group may contribute to weight loss, and participants tolerated the treatment well.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dandan Yang, Yin Hu, Zourong Ruan, Bo Jiang, Haiying Wang, Yichao Xu, Mengyue Hu, Min Yan, Honggang Lou
Summary: The aim of this study was to investigate the drug-drug interaction (DDI) of ciprofol injectable emulsion and mefenamic acid capsules in healthy subjects. The results showed no significant difference in exposure when ciprofol was administered with mefenamic acid. The combination of the two drugs did not affect the anesthesia effect of ciprofol.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hongrui Liu, Yiqun Yu, Lu Liu, Chunyan Wang, Nan Guo, Xiaojuan Wang, Xiaoqiang Xiang, Bing Han
Summary: The aim of this study was to evaluate the effect of pharmacokinetic changes on the antihypertensive effect of nifedipine caused by the co-administration with apatinib. The results showed that the exposure changes of nifedipine caused by combination with apatinib had little impact on the changes of systolic blood pressure. Therefore, nifedipine could be used in combination with apatinib without dose adjustment in clinic.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lamya S. Alnaim, Hind M. Almalki, Afrah M. Almutairi, Heba J. Salamah
Summary: The prevalence of drug-drug interactions (DDIs) in cancer patients is high, especially due to the multiple medications they receive. Factors such as the number of drugs, type of treatment, and length of stay in hospital contribute to the occurrence of DDIs.
Review
Food Science & Technology
Rita Roque Bravo, Ana Carolina Faria, Andreia Machado Brito-da-Costa, Helena Carmo, Premysl Mladenka, Diana Dias da Silva, Fernando Remiao
Summary: This article provides a brief overview of the prevalence and patterns of cocaine use, its physical-chemical properties and methods for analysis, pharmacokinetics, pharmacodynamics, and multi-level toxicity.
Review
Immunology
Talia Greenstein, Bree B. B. Aldridge
Summary: Combination therapy is crucial for treating tuberculosis to reduce disease relapse and prevent drug resistance. The different states of Mycobacterium tuberculosis and its tolerance to antibiotics in various lesion microenvironments require lengthy combination therapy. Developing combination therapies that target specific drug-tolerant cells is essential, and new tools are being developed to study drug combinations earlier in the drug development pipeline. This review discusses the factors underlying drug tolerance, how combination therapy targets these bacteria populations, and current modeling of drug tolerance for multidrug therapy in tuberculosis. Future studies should focus on developing better tools to model drug tolerance in tuberculosis infection specifically for combination therapy testing and the advancement of optimal drug regimens to clinical use.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Sojiro Kusumoto, Yusuke Kondo, Saki Izumi, Genki Nakata, Yoshitane Nozaki, Kazuya Maeda, Yasutsuna Sasaki, Ken-ichi Fujita, Hiroyuki Kusuhara
DRUG METABOLISM AND DISPOSITION
(2020)
Review
Pharmacology & Pharmacy
Kazuya Maeda
DRUG METABOLISM AND PHARMACOKINETICS
(2020)
Correction
Medicine, Research & Experimental
Saki Izumi, Yoshitane Nozaki, Hiroyuki Kusuhara, Koichiro Hotta, Toshiki Mochizuki, Takafumi Komori, Kazuya Maeda, Yuichi Sugiyama
MOLECULAR PHARMACEUTICS
(2020)
Article
Environmental Sciences
Takashi Kudo, Akihiro Inano, Sanae Midorikawa, Hitoshi Kubo, Kino Hayashi, Sawako Nakashima, Chizu Fukushima, Kazuya Maeda, Noboru Oriuchi, Shin Irie, Shunichi Yamashita, Hiroyuki Kusuhara
Article
Pharmacology & Pharmacy
Wooin Lee, Satoshi Koyama, Kiyoe Morita, Aya Kiriake, Ryota Kikuchi, Xiaoyan Chu, Nora Lee, Renato J. Scialis, Hong Shen, Emi Kimoto, Larry Tremaine, Naoki Ishiguro, Ralf Lotz, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama
Article
Pharmacology & Pharmacy
Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda, Hiroyuki Kusuhara
Summary: This study characterized the functions of major intestinal uptake/efflux drug transporters in freshly isolated human jejunum sections using the Ussing chamber system. The findings showed a good correlation between the mucosal-to-serosal apparent permeability coefficient of various drugs and reported human FaFg values, highlighting the importance of intestinal uptake transporters in facilitating drug absorption in humans.
DRUG METABOLISM AND DISPOSITION
(2021)
Review
Pharmacology & Pharmacy
Tatsuki Mochizuki, Tadahaya Mizuno, Kazuya Maeda, Hiroyuki Kusuhara
Summary: Drug transporters play crucial roles in eliminating compounds from the blood, with genetic variation and drug-drug interactions being underlying factors for pharmacokinetic differences of transporter substrates. Some endogenous substrates of drug transporters have been identified as biomarkers to assess transporter activity differences. Metabolomic analysis is a promising approach for identifying endogenous substrates through metabolites.
DRUG METABOLISM AND PHARMACOKINETICS
(2021)
Article
Chemistry, Medicinal
Takashi Yoshikado, Wooin Lee, Kota Toshimoto, Kiyoe Morita, Aya Kiriake, Xiaoyan Chu, Nora Lee, Emi Kimoto, Manthena V. S. Varma, Ryota Kikuchi, Renato J. Scialis, Hong Shen, Naoki Ishiguro, Ralf Lotz, Albert P. Li, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama
Summary: Hepatic uptake clearances of OATP1B substrates were compared between plated human hepatocytes (PHH) and suspended human hepatocytes (SHH), showing differences in uptake kinetics and cell-to-medium concentration ratios. PHH is useful for high-throughput evaluation of hepatic uptake/efflux clearances and Kp,Kuu, with caution needed for hydrophilic drugs with low uptake/cellular binding.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Shinpei Yoshida, Takayuki Honjo, Keita Iino, Ryunosuke Ishibe, Sylvia Leo, Tomoka Shimada, Teruhiko Watanabe, Masaya Ishikawa, Kazuya Maeda, Hiroyuki Kusuhara, Nobuaki Shiraki, Shoen Kume
Summary: This study aimed to generate matured small intestinal cells mimicking human small intestine from human-induced pluripotent stem cells (iPSCs). By culturing iPSC-derived intestinal progenitor cells on collagen vitrigel membrane and treating with a simple maturation medium, enterocyte-like cells were successfully generated, showing potential applications in drug transport and metabolism studies.
Review
Pharmacology & Pharmacy
Kazuya Maeda, Akihiro Hisaka, Kiyomi Ito, Yoshiyuki Ohno, Akihiro Ishiguro, Reiko Sato, Naomi Nagai
Summary: This review highlights the importance of clinical drug interaction studies during new drug development and introduces the general procedures proposed in a recently updated Japanese guideline. Drugs are classified based on their clearance pathway and potential intensity according to systematic reviews of the literature, which is useful for managing drug interactions in clinical practice.
DRUG METABOLISM AND PHARMACOKINETICS
(2021)
Article
Materials Science, Biomaterials
Sayaka Deguchi, Masahiro Tsuda, Kaori Kosugi, Ayaka Sakamoto, Natsumi Mimura, Ryosuke Negoro, Emi Sano, Takuro Nobe, Kazuya Maeda, Hiroyuki Kusuhara, Hiroyuki Mizuguchi, Fumiyoshi Yamashita, Yu-suke Torisawa, Kazuo Takayama
Summary: The study evaluated drug absorption to the PDMS device and investigated the drug responsiveness of human hepatocytes cultured in the PDMS device. The absorption rates of different compounds to the PDMS device were measured and found to be correlated with their octanol/water distribution coefficient values. Furthermore, the hepatocyte-chips were used to examine the response to drugs typically used to evaluate hepatic functions.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda, Hiroyuki Kusuhara
Summary: This study has demonstrated the usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells as an in vitro model for studying the impact of intestinal drug-metabolizing enzymes and transporters on substrate drugs' absorption in humans. The model was able to maintain the functions of major intestinal drug-metabolizing enzymes and transporters. It could be used for quantitative evaluation of the impact of these enzymes and transporters on drug absorption.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Pharmacology & Pharmacy
Yoshiki Hashimoto, Kazuyoshi Michiba, Kazuya Maeda, Hiroyuki Kusuhara
Summary: Efflux transport systems play a crucial role in inhibiting the absorption and distribution of drugs in the human body, with genetic variations and coadministered drugs affecting transporter expression and function. Utilizing in vitro experimental tools and mathematical modeling allows for accurate prediction of drug pharmacokinetics.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tatsuki Mochizuki, Maciej J. Zamek-Gliszczynski, Kenta Yoshida, Jialin Mao, Kunal Taskar, Hideki Hirabayashi, Xiaoyan Chu, Yurong Lai, Tadayuki Takashima, Kevin Rockich, Yoshiyuki Yamaura, Kaku Fujiwara, Tadahaya Mizuno, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara
Summary: This study assessed the quantitative performance of endogenous biomarkers for OATP1B1/1B3-mediated drug-drug interactions, with CP-I's AUCR and CmaxR showing high correlation with CysA AUC. The findings provide valuable information for accurate DDI predictions and enhance understanding of interindividual variability in DDI magnitude.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek-Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara
Summary: In this study, a physiologically-based pharmacokinetic (PBPK) model analysis was performed to interpret clinical drug-drug interaction (DDI) data, and the results suggest that PBPK model analysis of CP-I is a promising translational approach to predict OATP1B-mediated DDIs in drug development.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)