Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

(2013) Zamal Ahmed et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

(2012) Chi-Chuan Lin et al.   CELL

Function of Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) as a Mechanical Transducer in Flow-sensitive Segments of Renal Collecting Duct System

(2012) Jonathan Berrout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

(2012) Tom D. Bunney et al.   STRUCTURE

PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells

(2012) Narendra Thapa et al.   Cell Adhesion & Migration

Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer

(2011) Yoko Matsuda et al.   CANCER LETTERS

Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase C 2

(2011) K. L. Everett et al.   MOLECULAR AND CELLULAR BIOLOGY

Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A

(2011) Min Jin et al.   PLoS One

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site

(2009) Jae Hyun Bae et al.   CELL

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

(2009) Zamal Ahmed et al.   CELLULAR SIGNALLING

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

(2009) Jian-Jiang Hao et al.   JOURNAL OF CELL BIOLOGY

Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

(2009) Michael G. Gartside et al.   MOLECULAR CANCER RESEARCH

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

(2009) Tom D. Bunney et al.   MOLECULAR CELL

Determination of content and fatty acid composition of unlabeled phosphoinositide species by thin-layer chromatography and gas chromatography

(2008) Sabine König et al.   ANALYTICAL BIOCHEMISTRY

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

(2008) Zamal Ahmed et al.   BIOCHEMICAL JOURNAL

Phospholipase C 1 Is Required for Metastasis Development and Progression

(2008) G. Sala et al.   CANCER RESEARCH

Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform

(2008) Jiyoung Y. Cha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac Regulates Its Effector Phospholipase Cγ2through Interaction with a Split Pleckstrin Homology Domain

(2008) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation of cell motility and chemotaxis by phospholipid signaling

(2008) V. Kolsch et al.   JOURNAL OF CELL SCIENCE

Involvement of Fibroblast Growth Factor Receptor 2 Isoform Switching in Mammary Oncogenesis

(2008) J. Y. Cha et al.   MOLECULAR CANCER RESEARCH

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL