期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 20, 期 2, 页码 222-229出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2486
关键词
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资金
- US National Institutes of Health [GM 48413]
- Howard Hughes Medical Institute
The ISWI family of ATP-dependent chromatin remodelers represses transcription by changing nucleosome positions. ISWI regulates nucleosome positioning by requiring a minimal length of extranucleosomal DNA for moving nucleosomes. ISW2 from Saccharomyces cerevisiae, a member of the ISWI family, has a conserved domain called SLIDE (SANT-like ISWI domain) that binds to extranucleosomal DNA similar to 19 base pairs from the edge of nucleosomes. Loss of SLIDE binding does not perturb binding of the ATPase domain or the initial movement of DNA inside of nucleosomes. Not only is extranucleosomal DNA required to help recruit ISW2, but also the interactions of the SLIDE domain with extranucleosomal DNA are functionally required to move nucleosomes.
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