Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity

DNA cleavage and opening reactions of human topoisomerase II  are regulated via Mg2+-mediated dynamic bending of gate-DNA

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Central Dogma One Molecule at a Time

(2011) Carlos Bustamante et al.   CELL

The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks

(2011) A. D. Bates et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Bimodal Recognition of DNA Geometry by Human Topoisomerase IIα: Preferential Relaxation of Positively Supercoiled DNA Requires Elements in the C-Terminal Domain†

(2008) A. Kathleen McClendon et al.   BIOCHEMISTRY

Using 3′-Bridging Phosphorothiolates To Isolate the Forward DNA Cleavage Reaction of Human Topoisomerase IIα†

(2008) Joseph E. Deweese et al.   BIOCHEMISTRY

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS