4.5 Editorial Material

Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose

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NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 12, 页码 1212-1213

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NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2455

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  1. Medical Research Council [G0901606] Funding Source: researchfish
  2. Medical Research Council [G0901606] Funding Source: Medline
  3. MRC [G0901606] Funding Source: UKRI

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Three structures were recently reported for tyrosyl DNA phosphodiesterase 2 (Tdp2), a protein that protects the metazoan genome from shredding following abortive topoisomerase activity. The physiological significance of these findings is discussed here.

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