期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 6, 页码 650-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2293
关键词
-
资金
- Israel Science Foundation
- Merck
- Lilly Fulop
- Wolfson family charitable trust
- Azrieli Foundation
- European Research Council
- Helen and Martin Kimmel Award for Innovative Investigation
- California Institute for Regenerative Medicine [RN2-00906-1]
- US National Institutes of Health [R01 NS057221]
Primary microRNA cleavage by the Drosha-Dgcr8 'Microprocessor' complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues. We found that the autoregulatory feedback on Microprocessor expression is instrumental for balancing the efficiency and specificity of its activity by effectively tuning Microprocessor levels to those of its pri-miRNA substrate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据