Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Dae-Jin Kang, Seonggeun Zee, Min-Hee Park
Summary: Regular exercise, especially aerobic exercise, is beneficial for increasing serum high-density lipoprotein-cholesterol (HDL-C) levels in the general population. The optimal intensity and frequency of exercise to increase HDL quantity and enhance HDL quality in middle-aged women need to be determined. This study compared the changes in HDL quantity and quality among middle-aged women depending on exercise intensity, frequency, and duration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: The study demonstrates the physiological effects of alpha-synuclein on lipoprotein metabolism, showing its weaker phospholipid-binding ability compared to apoA-I. Incorporation of alpha-syn in reconstituted HDL affects the alpha-helicity and functionality of apoA-I, with potential destabilization of the secondary structure.
Article
Biochemistry & Molecular Biology
Sylwia Placzkowska, Katarzyna Solkiewicz, Iwona Bednarz-Misa, Ewa Maria Kratz
Summary: The study aimed to assess the relationship between sdLDL and other metabolic disorder parameters and identify markers of increased sdLDL concentration. The results showed that different lipid parameters and atherogenicity indexes are associated with high sdLDL concentration depending on the age group. Abnormal API and non-HDL-C may indicate cardiovascular disease risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: The incorporation of SAA in rHDL impairs the structural stability of apoA-I and exacerbates glycation of HDL and apoA-I.
Article
Food Science & Technology
Romuald Gaillard, Diane Gagnon, Veronique Perreault, Alice Marciniak, Yves Pouliot, Guillaume Brisson, Alain Doyen
Summary: The impact of ultra-high pressure homogenization (UHPH) on the structure of egg yolk granule proteins was evaluated. UHPH treatment destabilized and modified the structure of egg yolk granules, leading to improved water and oil binding capacities and stability. However, egg yolk granule solubility was not affected. These findings have important implications for the food industry in developing new egg yolk granule-based ingredients.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Dae-Jin Kang, Min-Hee Park, Ju-Hyun Kim
Summary: Long-term alcohol consumption, even in small amounts, causes a significant decrease in serum HDL-C and apoA-I levels in middle-aged women, along with atherogenic changes in LDL and HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Marta Turri, Elisa Conti, Chiara Pavanello, Francesco Gastoldi, Marcella Palumbo, Franco Bernini, Vittoria Aprea, Francesca Re, Alberto Barbiroli, Davide Emide, Daniela Galimberti, Lucio Tremolizzo, Francesca Zimetti, Laura Calabresi, AGAINST AD Grp
Summary: The purpose of this study was to evaluate cholesterol esterification and HDL subclasses in plasma and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients. The results showed that cholesterol esterification efficiency was reduced in the plasma of AD patients, and the unesterified cholesterol ratio was increased in CSF.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Maria Ramos-Caceres, Itziar Lamiquiz-Moneo, Ana Cenarro, Pilar Calmarza, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Jose Puzo, Jose M. Ordovas, Fernando Civeira, Martin Laclaustra
Summary: This study analyzes the relationship between triglycerides (TGs) and lipoprotein(a) (Lp(a)) concentrations. It found an inverse relationship between TG and Lp(a). Larger VLDL size, VLDLs enriched in apoE, and the apoE2/E2 genotype were associated with lower levels of Lp(a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Seung Hee Baek, Hyo-Seon Nam, Ji-Eun Kim, Dae-Jin Kang, Hyejee Na, Seonggeun Zee
Summary: Policosanols from different sources have been marketed for their potential to prevent dyslipidemia, diabetes, and hypertension by increasing HDL-C levels. However, there has been no study on how each policosanol influences the quality and functionality of HDL particles. This study compared the effects of different policosanols on lipoprotein metabolism using reconstituted HDLs in vitro and in zebrafish embryos.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Shane R. Thomas, Yunjia Zhang, Kerry-Anne Rye
Summary: The high density lipoprotein (HDL) fraction of human plasma is composed of spherical particles that are structurally uniform but heterogeneous in size, composition, and function. While numerous studies have shown that high levels of HDL cholesterol (HDL-C) are associated with decreased cardiovascular risk, recent clinical trials of HDL-C raising agents have failed to reduce cardiovascular events. Therefore, current research is focusing on the cardioprotective functions of HDLs and their potential use in treating other diseases.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Irina N. Gorshkova, Nathan L. Meyers, Haya Herscovitz, Xiaohu Mei, David Atkinson
Summary: Population studies have found a strong association between the natural human apoA-I variant apoA-I[K107del] and low HDL-C but normal apoA-I levels. This variant has unique properties, including faster adsorption to lipid surfaces, greater surface remodeling, and higher surface pressures on compression. These properties lead to increased binding to triglyceride-rich lipoproteins and impaired formation of large HDL particles. These factors contribute to the unusual phenotype associated with atherosclerosis.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Seung-Hee Baek, Dae-Jin Kang, Hyejee Na, Tomohiro Komatsu, Yoshinari Uehara
Summary: This study evaluated the efficacy and safety of 20 mg of Cuban policosanol in blood pressure and lipid/lipoprotein parameters of healthy Japanese subjects. After 12 weeks, the policosanol group showed significantly lower blood pressure, glycated hemoglobin, and blood urea nitrogen levels. The group also showed improved hepatic functions and HDL functionalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tomokazu Konishi, Risako Fujiwara, Tadaaki Saito, Nozomi Satou, Yurie Hayashi, Naoko Crofts, Ikuko Iwasaki, Yoshihisa Abe, Shinpei Kawata, Tatsuya Ishikawa
Summary: This study uses HPLC to analyze the levels of lipoproteins in 55 human serum samples and finds that these levels are distributed lognormally with estimated standard amounts and 95% ranges. Certain lipoprotein classes with narrow ranges could be ideal indicators for specific diseases. Additionally, the study reveals that multiple unhealthy lifestyle habits can significantly increase the levels of specific lipoprotein classes.
Article
Multidisciplinary Sciences
Maxime Nguyen, Abderrahmane Bourredjem, Lionel Piroth, Belaid Bouhemad, Antoine Jalil, Gaetan Pallot, Naig Le Guern, Charles Thomas, Victoria Bergas, Helene Choubley, Jean-Pierre Quenot, Pierre-Emmanuel Charles, Laurent Lagrost, Valerie Deckert, Jean-Paul Pais De Barros, Pierre-Gregoire Guinot, David Masson, Christine Binquet, Thomas Gautier, Mathieu Blot, Thomas Pilot
Summary: COVID-19 pneumonia in severe patients is associated with higher levels of NEFAs, lower apolipoprotein E, and lower HDL concentrations independently of other factors, which may play a role in the pathogenesis of COVID-19 and serve as potential therapeutic targets. Further investigations are needed to understand the role of NEFAs in the dysregulated immune response seen in COVID-19.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Alla M. Andreeva, Nina Lamash, V. I. Martemyanov, A. S. Vasiliev, I. Yu. Toropygin, D. V. Garina
Summary: In this study, the stress response and physiological adaptations of goldfish to critical salinity waters were investigated. The results showed increased plasma concentrations of cortisol, glucose, and Na+ after exposure to critical salinity for 21 days, indicating stress. The study also demonstrated that HDL remodeling plays a crucial role in maintaining osmotic homeostasis in fish.
JOURNAL OF FISH BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dedipya Yelamanchili, Jing Liu, Antonio M. Gotto, Ayrea E. Hurley, Willam R. Lagor, Baiba K. Gillard, W. Sean Davidson, Henry J. Pownall, Corina Rosales
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Review
Peripheral Vascular Disease
W. Sean Davidson, Allison L. Cooke, Debi K. Swertfeger, Amy S. Shah
Summary: The term HDL refers to a diverse collection of subparticles that play different roles in physiology. Recent research has described and characterized a few compositionally defined HDL subspecies, but more work is needed before these advancements can be translated into disease mitigation strategies. By combining targeted particle isolation techniques with large human studies, progress is being made in understanding the functions and implications of HDL subspecies for disease.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Hematology
Graziella E. Ronsein, Tomas Vaisar, W. Sean Davidson, Karin E. Bornfeldt, Jeffrey L. Probstfield, Kevin D. O'Brien, Xue-Qiao Zhao, Jay W. Heinecke
Summary: Niacin therapy does not reduce cardiovascular events in statin-treated subjects, despite increasing HDL-C levels and decreasing LDL-C and triglyceride levels. The addition of niacin to statin therapy results in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, potentially compromising the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yong-Hyun Han, Emily J. Onufer, Li-Hao Huang, Robert W. Sprung, W. Sean Davidson, Rafael S. Czepielewski, Mary Wohltmann, Mary G. Sorci-Thomas, Brad W. Warner, Gwendalyn J. Randolph
Summary: Research shows that HDL3 derived from the intestine can enter the bloodstream through the portal vein, preventing the binding of lipopolysaccharide and inflammatory activation of liver macrophages, thereby protecting the liver from injury caused by gut-derived LPS.
Article
Multidisciplinary Sciences
Jie Qu, Sarah Fourman, Maureen Fitzgerald, Min Liu, Supna Nair, Juan Oses-Prieto, Alma Burlingame, John H. Morris, W. Sean Davidson, Patrick Tso, Aditi Bhargava
Summary: APOA4 is a versatile apolipoprotein involved in lipid transport and metabolism, synthesized in the small intestine and transported to various tissues. LRP1 has been identified as the receptor for APOA4 in adipose tissue, where it promotes glucose uptake and interacts with APOA4 under different conditions.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
W. Sean Davidson, Amy S. Shah, Hannah Sexmith, Scott M. Gordon
Summary: The HDL proteome, identified through various studies using different methodologies across multiple laboratories, provides valuable insights into HDL function. Known functions of consensus HDL proteins extend beyond traditional roles in lipid transport, pointing towards involvement in innate immunity, inflammation, cell adhesion, hemostasis, protease regulation, as well as vitamin and metal binding. Further research is needed to address significant issues identified in these studies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Mathematics
Timothy J. Hodges, Sergio D. Molina
Summary: The paper discusses the definition and properties of F-2 semi-regular sequences, introduces a new framework for F-2 semi-regularity, and provides a possibility for solving the existence problem of semi-regular sequences by showing its relationship with the Koszul complex.
JOURNAL OF ALGEBRA
(2021)
Article
Biochemistry & Molecular Biology
Brynne E. Whitacre, Philip Howles, Scott Street, Jamie Morris, Debi Swertfeger, W. Sean Davidson
Summary: High levels of circulating triglycerides are associated with metabolic diseases. This study found that APOE on VLDL modulates LPL activity, which may be relevant to the pathogenesis of metabolic diseases.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shimpi Bedi, Jamie Morris, Amy Shah, Rachel C. Hart, W. Gray Jerome, Stephen G. Aller, Chongren Tang, Tomas Vaisar, Karin E. Bornfeldt, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Summary: This study investigates the structural transitions of apolipoprotein A-I (APOA1) in response to lipid binding during high-density lipoprotein (HDL) formation. The researchers generated different dimeric APOA1 molecules with covalently joined termini and tested their ability to form HDL particles. They found that the conformational freedom of the N- and C-termini of APOA1 is not critical for HDL particle formation, but important for cholesterol efflux.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Mathematics, Applied
Timothy J. Hodges, Hari R. Iyer
Summary: Investigation into the number of semi-regular sequences of length two over F-2 and providing a comprehensive description for each n.
FINITE FIELDS AND THEIR APPLICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Baohai Shao, Janet K. Snell-Bergeon, Laura L. Pyle, Katie E. Thomas, Ian H. de Boer, Vishal Kothari, Jere Segrest, William S. Davidson, Karin E. Bornfeldt, Jay W. Heinecke
Summary: The study aimed to determine which proteins carried by HDL might predict incident CVD in patients with type 1 diabetes mellitus. The results showed that only one HDL protein, SFTPB, predicted incident CVD in all tested models, independent of smoking status and other risk factors.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Hsuan-Chih N. Kuo, Zachary LaRussa, Flora Mengyang Xu, Kathryn West, Leslie Consitt, William Sean Davidson, Min Liu, Karen T. T. Coschigano, Haifei Shi, Chunmin C. C. Lo
Summary: Long-chain fatty acids induce apolipoprotein A4 (APOA4) production, leading to increased thermogenesis and triglyceride clearance in brown adipose tissue (BAT). Continuous infusion of recombinant APOA4 protein stimulates sympathetic activity and thermogenesis in BAT, and improves lipid and glucose metabolism.
Article
Biochemistry & Molecular Biology
John T. Melchior, Scott E. Street, Tomas Vaisar, Rachel Hart, Jay Jerome, Zsuzsanna Kuklenyik, Noemie Clouet-Foraison, Carissa Thornock, Shimpi Bedi, Amy S. Shah, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Summary: Through in-depth examination of particles with different apolipoprotein compositions in human HDL, it was found that LpA-I particles containing APOA1 consist of two discreetly sized populations, with larger particles having fewer APOA1 molecules than smaller particles. Additionally, HDL and particles containing both APOA1 and APOA2 exhibit a wider range and variation in particle sizes, suggesting that APOA2 may be the major contributor to HDL size heterogeneity.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
John T. Melchior, Debi K. Swertfeger, Jamie Morris, Scott E. Street, Carri R. Warshak, Jeffrey A. Welge, Alan T. Remaley, Janet M. Catov, W. Sean Davidson, Laura A. Woollett
Summary: Pregnancy induces physiological changes that affect the health and development of both the fetus and mother, including alterations in plasma lipoproteins. This study found that pregnant women have an increase in larger HDL particles and significant changes in lipid-associated proteins within different HDL size fractions, which could have implications on HDL function during pregnancy.
JOURNAL OF LIPID RESEARCH
(2021)