期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 18, 期 6, 页码 732-734出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2052
关键词
-
资金
- US National Institutes of Health [GM49243]
Cooperativity, a universal property of biological macromolecules, is typically characterized by a Hill slope, which can provide fundamental information about binding sites and interactions. We demonstrate, through simulations and single-molecule FRET (smFRET) experiments, that molecular heterogeneity lowers bulk cooperativity from the intrinsic value for the individual molecules. As heterogeneity is common in smFRET experiments, appreciation of its influence on fundamental measures of cooperativity is critical for deriving accurate molecular models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据