Structural basis of substrate discrimination and integrin binding by autotaxin

Crystallization and preliminary X-ray diffraction analysis of rat autotaxin

(2010) Jacqueline E. Day et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein

(2010) Jens Hausmann et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

ATX expression and LPA signalling are vital for the development of the nervous system

(2010) Stella Fotopoulou et al.   DEVELOPMENTAL BIOLOGY

Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin

(2010) Harald M. H. G. Albers et al.   JOURNAL OF MEDICINAL CHEMISTRY

The HADDOCK web server for data-driven biomolecular docking

(2010) Sjoerd J de Vries et al.   Nature Protocols

Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

(2010) Marion David et al.   PLoS One

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

The Absence of LPA2 Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer

(2009) Songbai Lin et al.   GASTROENTEROLOGY

Domain Interplay Mediated by an Essential Disulfide Linkage Is Critical for the Activity and Secretion of the Metastasis-promoting Enzyme Autotaxin

(2009) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin/Lysophospholipase D-mediated Lysophosphatidic Acid Signaling Is Required to Form Distinctive Large Lysosomes in the Visceral Endoderm Cells of the Mouse Yolk Sac

(2009) Seiichi Koike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

(2009) Zehra Pamuklar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin signaling regulating genes: effect on T2DM and cardiovascular risk

(2009) Sabrina Prudente et al.   Nature Reviews Endocrinology

MSDmotif: exploring protein sites and motifs

(2008) Adel Golovin et al.   BMC BIOINFORMATICS

Lysophosphatidic acid (LPA) and its receptors

(2008) Kyoko Noguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

(2008) Qing Huai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation

(2008) P Taghavi et al.   ONCOGENE