期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 16, 期 11, 页码 1192-1194出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1681
关键词
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资金
- Robert A. Welch Foundation [A-0015]
- S National Institutes of Health [PO1AIO60342, NIGMS27099]
- Office of the Vice President for Research at Texas AM University
- US Department of Energy, Basic Energy Sciences, Office of Science [DE-AC02-06CH11357]
R-21, the lysozyme of coliphage 21, has an N-terminal signal-anchor-release (SAR) domain that directs its secretion in a membrane-tethered, inactive form and then its release and activation in the periplasm. Both genetic and crystallographic studies show that the SAR domain, once extracted from the bilayer, refolds into the body of the enzyme and effects muralytic activation by repositioning one residue of the canonical lysozyme catalytic triad.
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