期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 15, 期 1, 页码 20-22出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb0108-20
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资金
- NATIONAL INSTITUTE ON AGING [R01AG011085] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG011085] Funding Source: Medline
DNA damage activates signaling cascades driven by the ATM-ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.
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