NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer

A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions

(2014) Robin G. Lerner et al.   NATURE CELL BIOLOGY

The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells

(2014) Isabelle Tremblay et al.   PLoS One

How to Take Autophagy and Endocytosis Up a Notch

(2014) Julia M. I. Barth et al.   Biomed Research International

Notch Inhibitor: a Promising Carcinoma Radiosensitizer

(2013) Shu-Dong Yu et al.   Asian Pacific Journal of Cancer Prevention

Inhibition of Notch recycling by Numb: Relevance and mechanism(s)

(2013) Lydie Couturier et al.   CELL CYCLE

U.S. Food and Drug Administration Approval: Vismodegib for Recurrent, Locally Advanced, or Metastatic Basal Cell Carcinoma

(2013) M. Axelson et al.   CLINICAL CANCER RESEARCH

Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila

(2013) Lydie Couturier et al.   CURRENT BIOLOGY

Cell Biology: Notch Recycling Is Numbed

(2013) Ilka Reichardt et al.   CURRENT BIOLOGY

Inhibition of Hedgehog/Gli Signaling by Botanicals: A Review of Compounds with Potential Hedgehog Pathway Inhibitory Activities

(2013) Sara Drenkhahn et al.   CURRENT CANCER DRUG TARGETS

Numb Regulates Acinar Cell Dedifferentiation and Survival During Pancreatic Damage and Acinar-to-Ductal Metaplasia

(2013) Renee L. Greer et al.   GASTROENTEROLOGY

Dynamic Methylation of Numb by Set8 Regulates Its Binding to p53 and Apoptosis

(2013) Gurpreet Kaur Dhami et al.   MOLECULAR CELL

Hypoxia, notch signalling and prostate cancer

(2013) Laure Marignol et al.   Nature Reviews Urology

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

(2013) Cathy C. Zhang et al.   Stem Cells Translational Medicine

NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128

(2013) R Nanta et al.   Oncogenesis

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Notch Signaling: Numb Makes the Difference

(2012) Bernd Giebel et al.   CURRENT BIOLOGY

Obesity and Prostate Cancer: Weighing the Evidence

(2012) Emma H. Allott et al.   EUROPEAN UROLOGY

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis

(2012) Corey Kelsom et al.   Cell and Bioscience

Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1

(2011) Anita E. Popko-Scibor et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells

(2011) Mengqian Chen et al.   CELL CYCLE

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells

(2011) Nanor Sirab et al.   INTERNATIONAL JOURNAL OF CANCER

Down regulation of CSL activity inhibits cell proliferation in prostate and breast cancer cells

(2011) Thomas Yong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch Signaling Modulates Hypoxia-Induced Neuroendocrine Differentiation of Human Prostate Cancer Cells

(2011) G. Danza et al.   MOLECULAR CANCER RESEARCH

Regulation of Notch1 signaling by delta-like ligand 1 intracellular domain through physical interaction

(2011) Jane Jung et al.   MOLECULES AND CELLS

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Two novel human NUMB isoforms provide a potential link between development and cancer

(2011) Aldona Karaczyn et al.   Neural Development

Acetylation controls Notch3 stability and function in T-cell leukemia

(2011) R Palermo et al.   ONCOGENE

GLI1 Confers Profound Phenotypic Changes upon LNCaP Prostate Cancer Cells That Include the Acquisition of a Hormone Independent State

(2011) Sandeep K. Nadendla et al.   PLoS One

MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer

(2011) Bin Xu et al.   PROSTATE

GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor

(2010) Guangchun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

(2010) Zhiwei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer

(2010) C. M. Misquitta-Ali et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Prostate cancer gene expression signature of patients with high body mass index

(2010) S Sharad et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer

(2009) Karin Rennstam et al.   BREAST CANCER RESEARCH AND TREATMENT

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

Cancer stem cells and radiotherapy

(2009) Michael Baumann et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Numb Regulates Post-endocytic Trafficking and Degradation of Notch1

(2009) Melanie A. McGill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb

(2008) Wei Kuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch Signaling: A Potential Therapeutic Target in Prostate Cancer

(2008) M. Villaronga et al.   CURRENT CANCER DRUG TARGETS

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

The Notch pathway in prostate development and cancer

(2008) Kevin G. Leong et al.   DIFFERENTIATION

Intracellular trafficking of Notch receptors and ligands

(2008) Christel Brou   EXPERIMENTAL CELL RESEARCH

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP

(2008) Hironori Kawahara et al.   JOURNAL OF CELL BIOLOGY

NUMB controls p53 tumour suppressor activity

(2008) Ivan N. Colaluca et al.   NATURE

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of mir-146a function in hormone-refractory prostate cancer

(2008) S.-L. Lin et al.   RNA

A role for Numb in p53 stabilization

(2008) Stephanie Carter et al.   GENOME BIOLOGY