Review
Chemistry, Analytical
Leila Syedmoradi, Michael L. Norton, Kobra Omidfar
Summary: Early and timely diagnosis of cancer is crucial for appropriate treatment and improved outcomes. Advances in biosensor technology have led to the development of point-of-care (POC) diagnostic devices that offer faster, more cost-effective testing processes. Incorporation of nanomaterials into sensing platforms has further enhanced sensitivity and reduced complexity. However, translating these innovative POC technologies into clinical settings faces challenges such as sampling procedures, sensitivity levels, and integration requirements.
Review
Medicine, Research & Experimental
Ying Wang, Bing-Shu Li, Zi-Hui Zhang, Zhi Wang, Yu-Ting Wan, Fu-Wen Wu, Jing-Chun Liu, Jia-Xin Peng, Hao-Yu Wang, Li Hong
Summary: Paeonol (PAE), a natural phenolic monomer, has shown promising anticancer effects, but its poor stability, low bioavailability, and short half-life have limited its clinical translation. Fortunately, nanomaterials and derivatives are being developed to overcome these shortcomings.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou, Fan Xia
Summary: Photodynamic therapy (PDT) is a promising non-invasive cancer treatment, but traditional photosensitizers have limitations. Aggregation-induced emission (AIE)-PSs, with their unique structure, exhibit enhanced photosensitivity in the aggregated state. This review discusses the design and preparation of AIE-PSs, their preclinical experiments in treating different types of tumors, and the potential clinical applications. It also presents perspectives on the further development of AIE-PSs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Oncology
Cinzia Baldessari, Stefania Pipitone, Eleonora Molinaro, Krisida Cerma, Martina Fanelli, Cecilia Nasso, Marco Oltrecolli, Marta Pirola, Elisa D'Agostino, Giuseppe Pugliese, Sara Cerri, Maria Giuseppa Vitale, Bruno Madeo, Massimo Dominici, Roberto Sabbatini
Summary: Bone metastases and bone health are important considerations in the management of prostate cancer patients. This review discusses the biology and clinical implications of bone metastases, as well as current therapeutic strategies. The importance of evaluating bone health and considering specific treatments is emphasized to address the risks associated with both poor bone health and bone metastasis.
Review
Oncology
Matti Poutanen, Malin Hagberg Thulin, Pirkko Harkonen
Summary: Sex steroids are major promoters of breast and prostate cancer growth. Current treatment methods include inhibiting sex steroid biosynthesis and blocking sex steroid receptor interactions. Enzyme inhibitors have been developed, but there is still potential for discovering new targets and mechanisms for more effective therapies.
NATURE REVIEWS CANCER
(2023)
Review
Oncology
Matti Poutanen, Malin Hagberg Thulin, Pirkko Harkonen
Summary: This review highlights the importance of inhibiting sex steroid biosynthesis to restrict their availability for receptor binding in the treatment of breast and prostate cancers. It discusses current therapies and potential new targets and mechanisms for more efficient treatment.
NATURE REVIEWS CANCER
(2023)
Article
Computer Science, Cybernetics
Adam Binks, Alice Toniolo, Miguel A. Nacenta
Summary: This study examines how individuals use intermediate representations during the essay-writing process and finds that important cognitive processing occurs during the transformations between different representations. This has significant implications for the design of tools to support intermediate representations.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES
(2022)
Review
Oncology
Martin K. Thomsen, Morten Busk
Summary: The incidence of prostate cancer is increasing, especially among elderly men, and pre-clinical models have played a vital role in gaining insights into the molecular alterations that drive cancer progression. The mouse model, with genetically modified strains and the inoculation of prostate cancer cells, has been invaluable for studying prostate cancer. Advances in the development of pre-clinical models, including the use of specific promoters for gene manipulation and orthoptic delivery of viral particles, have enhanced our understanding of prostate cancer. Animal models, especially mice, provide important tools for studying complex mechanisms in prostate cancer and improving treatment options.
Review
Biochemistry & Molecular Biology
Alexandra S. Latysheva, Vladimir A. Zolottsev, Vadim S. Pokrovsky, Irina I. Khan, Alexander Yu. Misharin
Summary: This mini-review focuses on novel nitrogen-containing steroid derivatives for prostate cancer treatment, discussing structures of new steroid compounds with significant activity in prostate cancer cells and pharmacological potency. It covers new derivatives of known anti-prostate cancer agents, as well as some related steroid-derived compounds.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Filip Ionescu, Jingsong Zhang, Liang Wang
Summary: Liquid biopsy is a powerful tool in the management of prostate cancer, as it can distinguish between different grades of cancer and predict treatment response. It can also detect genomic alterations with therapeutic implications. Technological advances in liquid biopsy promise to greatly improve patient management in the future.
Article
Cell Biology
Li Rebekah Feng, Jennifer J. Barb, Hannah Allen, Jeniece Regan, Leorey Saligan
Summary: This study found that patients with non-metastatic prostate cancer receiving neoadjuvant ADT reported more severe fatigue, possibly due to alterations in steroid hormone biosynthesis pathways related to sleep-related impairment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Mohammad Souri, M. Soltani, Farshad Moradi Kashkooli, Mohammad Kiani Shahvandi, Mohsen Chiani, Fatemeh Sadat Shariati, Mohammad Reza Mehrabi, Lance L. Munn
Summary: Nanotechnology has shown promising results in medical applications, particularly in oncology as drug delivery systems. However, the clinical translation of this technology is challenging. To optimize drug delivery systems for clinical translation, the physicochemical characteristics of nanoparticles can be specified. Researchers have focused on producing biocompatible materials, production technologies, or new formulations to improve efficiency and stability. The effects of design parameters can be studied using various methods. This review summarizes the advances and technologies in cancer nanomedicines for clinical translation and commercialization, as well as the existing challenges and opportunities in the field.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Neeraj Chauhan, Anjali Manojkumar, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: Prostate cancer is the most common type of cancer among men in the United States, and miRNA-205 plays a role in inhibiting tumor growth. miRNA-205 regulates cellular functions and can serve as a key biomarker and sensitize chemotherapy and radiation therapy in prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Multidisciplinary Sciences
Ebenezer Wiafe, Kofi Boamah Mensah, Frasia Oosthuizen, Varsha Bangalee
Summary: The study conducted a pilot survey in Ghana to investigate women's awareness of prostate cancer using an Akan tool. The majority of participants belonged to the Akan tribe and were fluent in the Akan language. While participants had a positive perception of the disease, their knowledge about the signs, symptoms, and risk factors of prostate cancer was found to be lacking.
Review
Biochemistry & Molecular Biology
Matteo Ferro, Ottavio de Cobelli, Mihai Dorin Vartolomei, Giuseppe Lucarelli, Felice Crocetto, Biagio Barone, Alessandro Sciarra, Francesco Del Giudice, Matteo Muto, Martina Maggi, Giuseppe Carrieri, Gian Maria Busetto, Ugo Falagario, Daniela Terracciano, Luigi Cormio, Gennaro Musi, Octavian Sabin Tataru
Summary: Radiomics and genomics play crucial roles in prostate cancer research, enhancing clinical value through mathematical analysis and machine learning. Validation of recent findings in large, randomized cohorts can establish the role of radiogenomics in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jason W. D. Hearn, Ghada AbuAli, Chad A. Reichard, Chandana A. Reddy, Cristina Magi-Galluzzi, Kai-Hsiung Chang, Rachel Carlson, Laureano Rangel, Kevin Reagan, Brian J. Davis, R. Jeff Rey Karnes, Manish Kohli, Donald Tindall, Eric A. Klein, Nima Sharifi
Article
Biology
Jianneng Li, Mohammad Alyamani, Ao Zhang, Kai-Hsiung Chang, Michael Berk, Zhenfei Li, Ziqi Zhu, Marianne Petro, Cristina Magi-Galluzzi, Mary-Ellen Taplin, Jorge A. Garcia, Kevin Courtney, Eric A. Klein, Nima Sharifi
Review
Biochemistry & Molecular Biology
Terri Goss Kinzy, Lauren A. De Stefano, Anthony M. Esposito, Jennifer M. Hurley, Rohini Roy, Anibal J. Valentin-Acevedo, Kai-Hsiung Chang, Jonathan Davila, Jennifer M. Defren, Jesse Donovan, Patricia Irizarry-Barreto, Anibal Soto, Riza M. Ysla, H. Liesel Copeland, Paul R. Copeland
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
(2008)
Article
Biochemistry & Molecular Biology
Kai-Hsiung Chang, Rui Li, Barbara Kuri, Yair Lotan, Claus G. Roehrborn, Jiayan Liu, Robert Vessella, Peter S. Nelson, Payal Kapur, Xiaofeng Guo, Hamid Mirzaei, Richard J. Auchus, Nima Sharifi
Article
Oncology
Rui Li, Kristen Evaul, Kamalesh K. Sharma, Kai-Hsiung Chang, Jennifer Yoshimoto, Jiayan Liu, Richard J. Auchus, Nima Sharifi
CLINICAL CANCER RESEARCH
(2012)
Article
Multidisciplinary Sciences
Kai-Hsiung Chang, Rui Li, Mahboubeh Papari-Zareei, Lori Watumull, Yan Daniel Zhao, Richard J. Auchus, Nima Sharifi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Oncology
Yuh-Shyan Tsai, Chen-Li Lai, Chih-Ho Lai, Kai-Hsiung Chang, Kaijie Wu, Shu-Fen Tseng, Ladan Fazli, Martin Gleave, Guanghua Xiao, Leah Gandee, Nima Sharifi, Loredana Moro, Tzong-Shin Tzai, Jer-Tsong Hsieh
