Review
Oncology
Xuan-Mei Piao, Young Joon Byun, Chuang-Ming Zheng, Sun Jin Song, Ho Won Kang, Won Tae Kim, Seok Joong Yun
Summary: Renal cell carcinoma (RCC) is a highly vascularized and immunogenic tumor, and the development of immune-checkpoint inhibitors has revolutionized its treatment. However, the clinical benefit of these agents is limited in patients with metastatic disease. In recent years, the microbiome has emerged as a novel therapeutic target and has shown promising values for the treatment of RCC. Understanding the microbiome of the tumor microenvironment is essential for modulating the response to immunotherapy in cancer patients.
Article
Oncology
Yue Wang, Xi Tian, Shu-Xuan Zhu, Wen-Hao Xu, Aihetaimujiang Anwaier, Jia-Qi Su, Hua-Lei Gan, Yuan-Yuan Qu, Jian-Yuan Zhao, Hai-Liang Zhang, Ding-Wei Ye
Summary: This study identified TPX2 as a potential prognostic and therapeutic biomarker in PRCC2. PRCC2 has worse overall survival and distinct molecular characteristics compared to PRCC1. Higher expression of TPX2 was associated with worse overall survival and elevated kinesin family gene expression in high-risk PRCC2. Abundance of tumor infiltrating M1 macrophage was significantly higher in PRCC2 and correlated with worse overall survival. mTOR inhibitors may have good efficacy in high-risk PRCC2 patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, Young-Woo Jo, Ji-Hoon Kim, Sang-Hyeon Hann, Jieon Park, Inkuk Park, Hyerim Park, Kyusang Yoo, Joonwoo Rhee, Jung-Wee Park, Yong Chan Ha, Young-Yun Kong
Summary: The study reveals that Mind bomb-1 is important for skeletal muscle maintenance with age by regulating Actn3, and that disruption of Mib1 leads to muscle atrophy, which can be rescued by downregulating Actn3 expression.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
James Heyward, Jacob Christopher, Sudipa Sarkar, Jung-Im Shin, Rita R. Kalyani, G. Caleb Alexander
Summary: From 2015 to 2019, there was a slight decrease in ambulatory diabetes visits in the United States, with a decline in metformin monotherapy and an increase in the use of GLP-1 receptor agonists and SGLT2 inhibitors as first-line therapies. Second-line therapy saw decreases in DPP-4 inhibitors and sulphonylureas, while SGLT2 inhibitors and GLP-1 receptor agonists increased in use.
DIABETES OBESITY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Sadiq Umar, Karol Palasiewicz, Anja Meyer, Prabhakaran Kumar, Bellur S. Prabhakar, Michael V. Volin, Rani Rahat, Mina Al-Awqati, Huan J. Chang, Ryan K. Zomorrodi, Jalees Rehman, Shiva Shahrara
Summary: Inflammatory and glycolytic responses in severe COVID-19 patients may be counter-regulated by targeting IRAK4, which plays a critical role in the molecular mechanism driven by SARS-CoV-2 Spike protein. Inhibition of IRAK4 rescues SARS-CoV-2-induced cytotoxic effects and reduces inflammatory markers and metabolic imprints, offering a promising therapeutic strategy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, General & Internal
Sumanta K. Pal, Catherine Tangen, Ian M. Thompson, Naomi Balzer-Haas, Daniel J. George, Daniel Y. C. Heng, Brian Shuch, Mark Stein, Maria Tretiakova, Peter Humphrey, Adebowale Adeniran, Vivek Narayan, Georg A. Bjarnason, Ulka Vaishampayan, Ajjai Alva, Tian Zhang, Scott Cole, Melissa Plets, John Wright, Primo N. Lara
Summary: In this study comparing different drug treatments for papillary renal cell carcinoma, cabozantinib was found to result in significantly longer progression-free survival compared to sunitinib, while savolitinib and crizotinib did not show an improvement in progression-free survival.
Article
Chemistry, Multidisciplinary
Bhanu Priya, Gurudutt Dubey, Sivapriya Kirubakaran
Summary: This study investigates the therapeutic potential of SPK98 in P53- and ATM-deficient cancer cells. The results show that SPK98 selectively sensitizes these cells and induces DNA double-strand breaks, making it a promising therapeutic molecule for P53- or ATM-deficient malignancies.
Article
Biochemistry & Molecular Biology
Jiaming Gao, Yunying Yao, Chenxuan Liu, Xi Xie, Donghe Li, Ping Liu, Zaiqi Wang, Baoyuan Zhang, Ruibao Ren
Summary: CDH1 deficiency is common in diffuse gastric cancer and triple negative breast cancer patients. Inhibition of ROS1 results in synthetic lethality in CDH1-deficient cancers, but often leads to adaptive resistance. Upregulation of FAK activity is observed in gastric and breast CDH1-deficient cancers upon resistance to ROS1 inhibitor therapy. FAK inhibition enhances the cytotoxicity potency of ROS1 inhibitor in CDH1-deficient cancer cell lines.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Patricia Pacheco, Nuno Marques, Paulo Rodrigues, Kamal Mansinho, Fernando Maltez, Nuno Janeiro, Claudia Franco, Diva Trigo, Joana Batista, Luis Duque, Maria Joao Lopes, Maria Joao Aleixo, Ana Rita Silva, Raquel Tavares, Joao Alves, Susana Peres, Diana Povoas, Sara Lino, Perpetua Gomes, Vania Araujo, Cristina Lopes
Summary: This study conducted in Portugal evaluated the safety and efficacy of triple therapy with dolutegravir plus 2 nucleoside reverse transcriptase inhibitors in treatment-naive PWHIV-2. The results showed that DTG combined with 2 NRTIs is a safe and effective first-line treatment for PWHIV-2, with a tolerability profile previously known.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Ayano Tsukagoshi-Yamaguchi, Masaya Koshizaka, Ryoichi Ishibashi, Ko Ishikawa, Takahiro Ishikawa, Mayumi Shoji, Shintaro Ide, Kana Ide, Yusuke Baba, Ryo Terayama, Akiko Hattori, Minoru Takemoto, Yasuo Ouchi, Yoshiro Maezawa, Koutaro Yokote, PRIME-V Study Group
Summary: This study compared the effects of ipragliflozin and metformin on metabolomics to understand their biological effects. Results showed that ipragliflozin significantly reduced visceral fat area compared to metformin, and detected metabolites that may contribute to visceral fat reduction.
Article
Multidisciplinary Sciences
Mototsugu Nagao, Jun Sasaki, Hitoshi Sugihara, Kyoko Tanimura-Inagaki, Taro Harada, Ichiro Sakuma, Shinichi Oikawa
Summary: The STREAM study evaluated the efficacy and safety of sitagliptin treatment in older Japanese patients with type 2 diabetes. The results showed that sitagliptin treatment effectively improved glycemic control in older patients without any serious adverse effects.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Antoine Simoneau, Rosalinda Xiong, Lee Zou
Summary: PARP inhibitor (PARPi) generates DNA double-strand breaks (DSBs) predominantly in a trans cell cycle manner by inducing single-stranded DNA (ssDNA) gaps during the first S phase after exposure. BRCA1/2-deficient cells are unable to effectively repair DSBs, resulting in the unique efficacy of PARPi in these cells.
GENES & DEVELOPMENT
(2021)
Article
Urology & Nephrology
Laura S. Schmidt, Cathy D. Vocke, Christopher J. Ricketts, Zoe Blake, Kristin K. Choo, Deborah Nielsen, Rabindra Gautam, Daniel R. Crooks, Krista L. Reynolds, Janis L. Krolus, Meena Bashyal, Baktiar Karim, Edward W. Cowen, Ashkan A. Malayeri, Maria J. Merino, Ramaprasad Srinivasan, Mark W. Ball, Berton Zbar, W. Marston Linehan
Summary: This study characterized the clinical manifestations and genetic basis of a familial cancer syndrome in patients with lipomas and Birt-Hogg-Dube-like clinical manifestations. By genomic analysis, a germline pathogenic variant in PRDM10 was identified, which may lead to reduced FLCN expression and TFE3-induced tumor formation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Yang, Xue-Ming Li, Ya-Jun Hu, Meng-Ni Zhang, Jin Yao, Bin Song
Summary: FH-deficient RCC shows distinct MDCT features compared to pRCC type II, being more common in younger patients and larger in size, with a cystic solid pattern and tendency for metastasis. There is no significant difference in imaging features between germline and somatic mutation subgroups.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Dermatology
Britney N. Wilson, Ann M. John, Marc Zachary Handler, Robert A. Schwartz
Summary: Neurofibromatosis type 1 is a common disorder that requires early diagnosis for proper guidance on preventive measures. Mutations in the NF1 gene lead to loss of function of the neurofibromin protein, which affects the regulation of the RAS signaling pathway. Treatment options include drugs and radiofrequency therapy.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Correction
Urology & Nephrology
Hiroki Hagimoto, Noriyuki Makita, Yuta Mine, Hidetoshi Kokubun, Shiori Murata, Yohei Abe, Masashi Kubota, Naofumi Tsutsumi, Toshinari Yamasaki, Mutsushi Kawakita
Article
Oncology
Hiroaki Ikesue, Kenta Yamaoka, Ayako Matsumoto, Masaki Hirabatake, Nobuyuki Muroi, Toshinari Yamasaki, Mutsushi Kawakita, Tohru Hashida
Summary: This study investigated the risk factors for proteinuria and the protective effect of renin-angiotensin system (RAS) inhibitors in patients with renal cell carcinoma (RCC) receiving axitinib. The results showed that pre-existing proteinuria and non-RAS inhibitor use were significantly associated with the development of higher-grade proteinuria.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masaki Hirabatake, Hiroaki Ikesue, Yuna Iwama, Kei Irie, Shintaro Yoshino, Toshinari Yamasaki, Tohru Hashida, Mutsushi Kawakita, Nobuyuki Muroi
Summary: The study investigated the efficacy of a collaborative management program between pharmacists and urologists for CRPC patients receiving enzalutamide, and found that collaborative management was useful for prolonging the time to enzalutamide discontinuation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Nobuaki Shimizu, Syed A. Hussain, Wataru Obara, Toshinari Yamasaki, Satoru Takashima, Takahiro Hasegawa, Motofumi Iguchi, Kenji Igarashi, Osamu Ogawa, Tomoaki Fujioka
Summary: S-588410 demonstrates a high rate of cytotoxic T-lymphocyte induction and a modest clinical response as maintenance therapy in patients with advanced or metastatic urothelial carcinoma. The most frequent treatment-emergent adverse event is injection-site reactions.
Review
Oncology
Chen Yao, Tian Zhang, Tuoqi Wu, James Brugarolas
Summary: Immunotherapy has had a significant impact on renal cell carcinoma (RCC). Combining anti-angiogenic agents with immune checkpoint inhibitors has transformed patient outcomes. The challenges now include patient selection, resistance mechanisms, and optimizing treatment sequencing. Further research may pave the way for the next generation of therapies.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Masashi Kubota, Toshinari Yamasaki, Shiori Murata, Yohei Abe, Yoichiro Tohi, Yuta Mine, Hiroki Hagimoto, Hidetoshi Kokubun, Issei Suzuki, Naofumi Tsutsumi, Koji Inoue, Mutsushi Kawakita
Summary: This study compared the surgical and functional outcomes between robot-assisted and laparoscopic methods of cortical-renorrhaphy-omitting partial nephrectomy. The study found that the robot-assisted group had better outcomes in terms of shorter operation time, warm ischemic time, less blood loss, lower incidence of complications, higher preservation rate of renal function, and higher achievement rate of trifecta compared to the laparoscopic group.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Yuta Mine, Toshinari Yamasaki, Takanari Kambe, Hiroki Hagimoto, Hidetoshi Kokubun, Yuto Hattori, Yohei Abe, Masashi Kubota, Naohumi Tsutsumi, Mutsushi Kawakita
Summary: Two cases of retrocaval ureter in adults were treated with robot-assisted laparoscopic surgery. Robotic ureteroureterostomy with dissection of the entire length of the retrocaval portion of the right ureter was performed without complications. Renal stone removal was also performed in one case. The robot-assisted procedure proved to be safe and feasible for the surgical repair of a retrocaval ureter.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Article
Orthopedics
Masashi Kubota, Takashi Matsuoka, Yuta Mine, Hiroki Hagimoto, Hidetoshi Kokubun, Shiori Murata, Noriyuki Makita, Yuto Hattori, Issei Suzuki, Yohei Abe, Yoichiro Tohi, Naofumi Tsutsumi, Toshinari Yamasaki, Koji Inoue, Mutsushi Kawakita
Summary: This study aimed to assess the impact of perioperative continuation of antithrombotic therapy on bleeding and complications in patients undergoing laparoscopic radical nephrectomy and nephroureterectomy. The results indicate that perioperative use of antithrombotic agents does not increase the risk of bleeding and can be considered safe.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Article
Oncology
Kangsan Kim, Huocong Huang, Pravat Kumar Parida, Lan He, Mauricio Marquez-Palencia, Tanner C. Reese, Payal Kapur, James Brugarolas, Rolf A. Brekken, Srinivas Malladi
Summary: Cell competition leads to the displacement of latent metastatic cells from the primary tumor, with disruption of this process resulting in reduced metastatic incidence. Kidney cancer has enriched tumor subclones with latent metastatic traits, which are associated with rapid onset of metastases and reduced disease-free survival. The findings highlight the importance of cell competition in shaping metastatic latency and relapse.
Article
Oncology
Kiyonao Nakamura, Yoshiki Norihisa, Itaru Ikeda, Haruo Inokuchi, Rihito Aizawa, Toshiyuki Kamoto, Tomomi Kamba, Takahiro Inoue, Toshinari Yamasaki, Shusuke Akamatsu, Takashi Kobayashi, Osamu Ogawa, Takashi Mizowaki
Summary: This study evaluates the outcomes of whole-pelvic simultaneous integrated boost intensity-modulated radiation therapy combined with androgen deprivation therapy in pelvic node-positive prostate cancer. The results show that the treatment can be safely administered and has low rates of biochemical relapse. Additionally, the International Society of Urological Pathology grade group 5 and post-treatment detectable nadir PSA levels are associated with worse survival and progression of castration resistance.
Article
Urology & Nephrology
Hiroki Hagimoto, Takanari Kambe, Yuta Mine, Hidetoshi Kokubun, Yuto Hattori, Yohei Abe, Masashi Kubota, Naofumi Tsutsumi, Toshinari Yamasaki, Mutsushi Kawakita
Summary: This study found that omitting drain placement after laparoscopic nephroureterectomy did not increase postoperative complications or lymphocele and shortened the length of hospital stay.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Oncology
Masashi Takeda, Hiromasa Sakamoto, Noboru Shibasaki, Tomohiro Fukui, Toshihiro Magaribuchi, Takayuki Sumiyoshi, Noriaki Utsunomiya, Atsuro Sawada, Takayuki Goto, Takashi Kobayashi, Koji Ueda, Toshinari Yamasaki, Osamu Ogawa, Shusuke Akamatsu
Summary: Extracellular vesicles (EVs) secreted by bone metastatic renal cell carcinoma (RCC) cells promote angiogenesis and gap formation in capillary endothelium in bone marrow, contributing to the formation of bone metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Hiroki Hagimoto, Mutsushi Kawakita, Toshinari Yamasaki
JOURNAL OF UROLOGY
(2023)
Article
Immunology
Masashi Takeda, Soki Kashima, Yasushi Fuchigami, Takayuki Yoshino, Tatsuki R. Kataoka, Toshinari Yamasaki, Hiroshi Kagamu, Takashi Kobayashi, Shusuke Akamatsu
Summary: This study reported a case of RCCU-MP treated with combined immune checkpoint blockade, showing initial response but disease progression later on.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Urology & Nephrology
Masashi Kubota, Takashi Matsuoka, Hiroki Hagimoto, Hidetoshi Kokubun, Yuta Mine, Shiori Murata, Yohei Abe, Toshinari Yamasaki, Mutsushi Kawakita
JOURNAL OF UROLOGY
(2021)