The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease

C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy

(2013) Sørge Kelm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study

(2013) Daniel J Wallace et al.   ANNALS OF THE RHEUMATIC DISEASES

Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab

(2013) E. A. Rossi et al.   BLOOD

B cells

(2013) Thomas Dörner et al.   CURRENT OPINION IN RHEUMATOLOGY

Genetic susceptibility to SLE: Recent progress from GWAS

(2013) Yong Cui et al.   JOURNAL OF AUTOIMMUNITY

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

(2013) Matthew S. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22

(2013) F. Pfrengle et al.   JOURNAL OF IMMUNOLOGY

Rituximab in systemic lupus erythematosus: an updated systematic review and meta-analysis

(2013) B Duxbury et al.   LUPUS

Suppressing the Antibody Response with Siglec Ligands

(2013) Lars Nitschke   NEW ENGLAND JOURNAL OF MEDICINE

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling

(2013) J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation

(2012) N. Sieger et al.   ARTHRITIS AND RHEUMATISM

Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues

(2012) Astrid Schweizer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model

(2012) Miriam Wöhner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

(2010) Ira Surolia et al.   NATURE

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

(2009) Bao Hoa Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies

(2009) Isaac T. W. Harley et al.   NATURE REVIEWS GENETICS

Sialylated multivalent antigens engage CD22in transand inhibit B cell activation

(2009) Adam H. Courtney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

(2008) Annaiah Cariappa et al.   JOURNAL OF EXPERIMENTAL MEDICINE