Review
Cardiac & Cardiovascular Systems
Eloi Marijon, Ana Mocumbi, Kumar Narayanan, Xavier Jouven, David S. Celermajer
Summary: Rheumatic heart disease is a valvular damage caused by acute rheumatic fever, predominantly occurring in childhood and adolescence. Although eradicated in developed countries, it remains a significant burden in developing nations.
EUROPEAN HEART JOURNAL
(2021)
Article
Rheumatology
Chiara Tani, Dina Zucchi, Elisa Bellis, Mehret Birru Talabi, Charlotte Frise, Guilherme Ramires de Jesus, Hege Svean Koksvik, Gema Maria Lledo, Arsene Mekinian, Diana Marinello, Ilaria Palla, Puja Mehta, Luis Saez Comet, Shoela Shaimaa, Hieronymus T. W. Smeele, Rosaria Talarico, Antonio Brucato, Munther Khamashta, Yehuda Shoenfeld, Angela Tincani, Marta Mosca
Summary: An international survey was conducted to map existing organizational care pathways in clinical centers of expertise that care for pregnant women affected by rare and complex connective tissue diseases (rcCTDs). The survey collected answers from 69 centers in 21 countries, revealing the involvement of multidisciplinary teams in patient care and the lack of attention given to specific rcCTDs diseases in some centers. Additionally, variations were found in pre-pregnancy care, pregnancy monitoring protocols, and access to therapies during pregnancy.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Maria Maslinska, Joanna Dmowska-Chalaba, Michal Jakubaszek
Summary: The role of IgG4 in IgG4-RD and other autoimmune diseases has attracted attention. IgG4, as a unique subclass of immunoglobulins, is generally considered non-inflammatory and tolerance inducing, but in IgG4-RD, it may play a pathogenic role in fibrogenesis and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Weilin Chen, Qi Wang, Bin Zhou, Lihua Zhang, Honglin Zhu
Summary: Rheumatic diseases are chronic autoimmune disorders with poorly understood mechanisms, but recent research suggests that cell metabolism plays a crucial role in their pathogenesis. By focusing on lipid metabolism profiles and mechanisms, new insights for clinical treatment of rheumatic diseases can be gained.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yuanji Dong, Bingxia Ming, Lingli Dong
Summary: This review article summarizes the physiological function of HMGB1 in mammalian cells, its involvement in inflammatory responses and autoimmunity, and discusses the recent advances and targeted therapy strategies in rheumatic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hugo O. Besedovsky, Adriana Del Rey
Summary: The immune system, while evolved for protection, can have lethal effects when over-activated. These effects, mediated by old cytokines, are important in limiting risk of transmission of highly mutating pathogens.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Chemistry, Medicinal
Jean Marcos De Souza, Thiago Junqueira Trevisan, Samara Rosa Sepresse, Ana Carolina Londe, Marcondes Cavalcante Franca Junior, Simone Appenzeller
Summary: Peripheral neuropathy (PN) is a common challenge in the clinical practice of systemic rheumatic diseases. This literature review provides a comprehensive approach to the diagnosis and management of PN related to systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, and systemic vasculitis, including evidence-based treatment strategies.
Review
Cell Biology
Alessandra Ida Celia, Serena Colafrancesco, Cristiana Barbati, Cristiano Alessandri, Fabrizio Conti
Summary: Autophagy and apoptosis play important roles in rheumatic diseases, and the dysregulation of their balance may contribute to the development of these diseases. Understanding the mechanisms of autophagy is of great significance for the research and treatment of rheumatic diseases.
Review
Cell & Tissue Engineering
Yajing Wang, Dan Ma, Zewen Wu, Baoqi Yang, Rong Li, Xingxing Zhao, Helin Yang, Liyun Zhang
Summary: Mesenchymal stem cells have great application value in cell replacement therapy and tissue repair, and their application in the treatment of rheumatic diseases is receiving increasing attention. These cells have the ability to differentiate into various cell types and are involved in immune regulation, inflammation alleviation, anti-fibrotic properties, and vascular repair.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Allergy
Mengdi Jiang, Yueting Li, Chendan Jiang, Lidan Zhao, Xuan Zhang, Peter E. Lipsky
Summary: With advances in information technology, the demand for using data science to enhance healthcare and disease management is rapidly increasing. Machine learning (ML) has become ubiquitous and indispensable for solving complex problems in various scientific fields. In the analysis of rheumatic diseases, ML is anticipated to be extremely helpful in deciphering the inherent interrelationships, optimizing therapeutic strategies, and predicting outcomes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Paola Galozzi, Daniela Basso, Mario Plebani, Andrea Padoan
Summary: Artificial intelligence (AI) has become a valuable tool for improving diagnosis, risk stratification, and personalized medicine in rheumatic diseases. Machine learning algorithms can analyze large amounts of laboratory data to classify patients, determine disease subtypes, and discover biomarkers. This review provides examples of machine learning models using laboratory data and insights into their strengths and limitations for specific rheumatic diseases.
CLINICA CHIMICA ACTA
(2023)
Article
Rheumatology
Teresa Carbone, Valentina Picerno, Vito Pafundi, Ernesto Esposito, Pietro Leccese, Angela Anna Padula, Salvatore D'Angelo
Summary: The COVID-19 pandemic has significantly impacted rheumatological clinical practice and autoimmunity testing demands, resulting in a decrease in laboratory test volumes and first rheumatological visits and diagnoses in 2020. However, an equivalent or higher percentage of positive autoimmunity results were recorded in outpatient services during 2020 compared to the prepandemic state, with new diagnoses mainly affected by less severe diseases.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meike J. Saul, Isabell Baumann, Annalisa Bruno, Anne C. Emmerich, Julia Wellstein, Sarah M. Ottinger, Annalisa Contursi, Melania Dovizio, Sandra Donnini, Stefania Tacconelli, Joan Raouf, Helena Idborg, Stefan Stein, Marina Korotkova, Rajkumar Savai, Erika Terzuoli, Gianluca Sala, Werner Seeger, Per-Johan Jakobsson, Paola Patrignani, Beatrix Suess, Dieter Steinhilber
Article
Pharmacology & Pharmacy
Filip Bergqvist, Elena Ossipova, Helena Idborg, Joan Raouf, Antonio Checa, Karin Englund, Petter Englund, Payam Emami Khoonsari, Kim Kultima, Craig E. Wheelock, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Karin Larsson, Julia Steinmetz, Filip Bergqvist, Samsul Arefin, Linda Spahiu, Johan Wannberg, Sven-Christian Pawelzik, Ralf Morgenstern, Patric Stenberg, Karolina Kublickiene, Marina Korotkova, Per-Johan Jakobsson
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Konstantin Carlberg, Marina Korotkova, Ludvig Larsson, Anca Catrina, Patrik L. Stahl, Vivianne Malmstrom
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Anna Kock, Filip Bergqvist, Julia Steinmetz, Lotta H. M. Elfman, Marina Korotkova, John Inge Johnsen, Per-Johan Jakobsson, Per Kogner, Karin Larsson
Article
Immunology
Anett B. Hegewald, Kai Breitwieser, Sarah M. Ottinger, Fariborz Mobarrez, Marina Korotkova, Bence Rethi, Per-Johan Jakobsson, Anca I. Catrina, Heidi Wahamaa, Meike J. Saul
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Julia Steinmetz-Spah, Samsul Arefin, Karin Larsson, Jabin Jahan, Neja Mudrovcic, Lars Wennberg, Peter Stenvinkel, Marina Korotkova, Karolina Kublickiene, Per-Johan Jakobsson
Summary: This study reveals the vasodilating effects of mPGES-1 inhibition in human microvasculature and suggests the involvement of multiple signaling pathways besides the PGI(2) pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lotstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H. Hensvold, Anca Catrina, Peter K. Sorger, Vivianne Malmstrom, Aviv Regev, Patrik L. Stahl
Summary: Spatial transcriptomics is used to study the local interactions in synovial tissue of rheumatoid arthritis patients. The results provide valuable insights into the spatial organization of cell populations and inflammation associated with rheumatoid arthritis.
COMMUNICATIONS BIOLOGY
(2022)
Review
Medicine, General & Internal
Per-Johan Jakobsson, Luke Robertson, Janika Welzel, Mingshu Zhang, Yang Zhihua, Gao Kaixin, Huang Runyue, Wen Zehuai, Marina Korotkova, Ulf Goransson
Summary: Chinese medicine has a long tradition of use in the treatment and prevention of rheumatoid arthritis (RA). This article summarizes the background, mechanisms, and proposed clinical trial for using Chinese herbal medicine in the prevention of RA. RA is an autoimmune, inflammatory disease that primarily affects the joints and is associated with genetic variations and smoking.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Uta Hardt, Konstantin Carlberg, Erik af Klint, Peter Sahlstrom, Ludvig Larsson, Annika van Vollenhoven, Susana Hernandez Machado, Lena Israelsson, Khaled Amara, Karine Chemin, Marina Korotkova, Gunilla B. Karlsson Hedestam, Anca Catrina, Sarah A. Teichmann, Patrik L. Stahl, Vivianne Malmstrom
Summary: This study investigated the presence of differentiated B cells in the joint tissue of patients with Rheumatoid Arthritis (RA) at the onset of the disease. The findings showed that different types of B cells, including memory and plasma cells, were present regardless of the patients' autoantibody status. The study also revealed the mechanisms of local B cell maturation and plasma cell survival in the tissue. Furthermore, the research demonstrated the presence of local autoreactive plasma cell differentiation in joint biopsies captured from untreated early RA.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Julia Steinmetz-Spah, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Ronnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggstrom, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Summary: This study reveals the formation of 15dPGJ(2)-GS and 15dPGJ(2)-Cys in mouse and human immune cells, demonstrates the involvement of microsomal glutathione S-transferase 3 in their biosynthesis, and finds that inhibition of mPGES-1 does not alter their formation.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yuze Zhang, Julia Steinmetz-Spah, Helena Idborg, Liyuan Zhu, Huihui Li, Haojie Rao, Zengrong Chen, Ziyi Guo, Lejia Hu, Chuansheng Xu, Hong Chen, Marina Korotkova, Per-Johan Jakobsson, Miao Wang
Summary: Inhibition of mPGES-1 can prevent chronic adverse cardiac remodeling after myocardial infarction, which may serve as a potential therapeutic strategy for HFrEF.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Ahlem Zaghmi, Erdem Aybay, Long Jiang, Mingmei Shang, Julia Steinmetz-Spah, Fredrik Wermeling, Per Kogner, Marina Korotkova, Paivi Ostling, Per-Johan Jakobsson, Brinton Seashore-Ludlow, Karin Larsson
Summary: High-throughput drug screening can discover new anticancer drugs, but monolayer cell cultures have limitations, requiring alternative models. Three-dimensional cell cultures, such as multicellular tumor spheroids (MCTS), mimic tumor architecture and offer promising opportunities for drug discovery. In this study, a neuroblastoma MCTS model was developed for high-content drug screening and to decipher the mechanisms underlying synergistic drug combinations in this disease model.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jianyang Liu, Bing Peng, Julia Steinmetz-Spah, Helena Idborg, Marina Korotkova, Per-Johan Jakobsson
Summary: mPGES-1 is the key enzyme for PGE2 generation and its inhibition has shown to be a safe and effective therapeutic strategy. In addition to reduced PGE2 formation, modulation of other prostanoids may also contribute to the therapeutic effects. This study found that mPGES-1 inhibition led to a shift to the PGD2 pathway in certain cells, while enhancing prostacyclin production in rheumatoid arthritis synovial fibroblasts.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2023)
Article
Rheumatology
Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E. Lundberg, Marina Korotkova
ARTHRITIS RESEARCH & THERAPY
(2018)