Review
Pharmacology & Pharmacy
Jing Xie, Cuixia He, Yue Su, Yuzhou Ding, Xingyu Zhu, Yuanyuan Xu, Jiaxiang Ding, Huan Zhou, Hongju Wang
Summary: This review systematically discusses the regulatory roles of miRNAs in gout and their potential applications in the treatment and diagnosis of gout.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Kanon Jatuworapruk, Rebecca Grainger, Nicola Dalbeth, Ratchaya Lertnawapan, Punchong Hanvivadhanakul, Patapong Towiwat, Lianjie Shi, William J. Taylor
Summary: This study developed and validated a risk stratification tool for predicting gout flare in hospitalized patients with comorbid gout. The GOUT-36 rule, which includes four items, showed good sensitivity and specificity for classifying high-risk patients. This tool can inform clinical decisions and future research on preventing inpatient gout flares.
Review
Immunology
Shuangshuang Li, Guanhua Xu, Junyu Liang, Liyan Wan, Heng Cao, Jin Lin
Summary: Gout is a common form of inflammatory arthritis where urate crystals deposit in joints and surrounding tissues. The standardized and effective treatment of gout is important but hindered by poor adherence to medication. Advanced imaging modalities like ultrasonography, dual-energy computed tomography, and magnetic resonance imaging have been found to play a significant role in early diagnosis and evaluating treatment effectiveness for gout.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Xiaoli Li, Qin Shao, Jingfang Shen, Shaohui Ren, Lianju Li, Hua Lu, Shubo Chen
Summary: This observational study found that low-dose febuxostat and colchicine prophylaxis were equally effective in preventing gout flares, while high-dose febuxostat alone increased the risk of gout flares.
Article
Rheumatology
Thomas Bardin, Yves-Marie Ducrot, Quang Nguyen, Emmanuel Letavernier, Jeremy Zaworski, Hang-Korng Ea, Frederic Touzain, Minh Duc Do, Julien Colot, Yann Barguil, Antoine Biron, Matthieu Resche-Rigon, Pascal Richette, Corinne Collet
Summary: This study identified three rare LDHD gene variants associated with juvenile-onset gout in three different ethnicities. The variants were found to cause decreased urate clearance and increased levels of d-lactate in blood and urine.
Review
Nutrition & Dietetics
Youssef M. Roman
Summary: Gout is a metabolic disorder that is on the rise globally, and its development and recurrence can be influenced by factors such as diet, culture, and social determinants of health. A holistic assessment and culturally tailored dietary recommendations can help optimize treatment outcomes for gout patients. Further research is needed to understand the role of gene-diet interactions in hyperuricemia and gout.
Editorial Material
Urology & Nephrology
Andrew J. Mallett, Nine Knoers, John Sayer, Zornitza Stark
Summary: There are key differences between clinical genomics and research genomics. Focusing on clinical genomics approaches in genomic testing for nephrology clinical care can ensure optimal resource utilization and maximum patient benefit.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Reproductive Biology
Xiaoyan Wang, Zi-Jiang Chen
Summary: This article comprehensively summarizes the development and achievements of POI research in China over the past decade, highlighting significant progress and milestone achievements in etiology, diagnosis, and treatment.
BIOLOGY OF REPRODUCTION
(2022)
Review
Chemistry, Medicinal
Shalini Sharma, Mukesh K. Pandey
Summary: This article highlights the significant progress made in molecular imaging and radionuclide therapy in the last two decades. It discusses advancements in radiometal-based positron emission tomography, single photon emission computerized tomography, and radionuclide therapy in terms of their production routes and ease of radiolabeling. The review also includes the use of astatine, a metalloid, in imaging and radionuclide therapy. Furthermore, it explores beta-minus and alpha-emitting radionuclides for therapy, focusing on their production routes, targeted radiopharmaceuticals, and current clinical translation stage.
Article
Medicine, General & Internal
Jasvinder A. Singh, Amy Joseph, Joshua Baker, Joshua S. Richman, Terrence Shaneyfelt, Kenneth G. Saag, Seth Eisen
Summary: In African-American gout patients, a culturally appropriate gout-storytelling intervention was not superior to attention control for improving gout outcomes.
News Item
Multidisciplinary Sciences
Ewen Callaway, Heidi Ledford
Summary: Svante Paabo's discoveries using ancient DNA have had a significant impact on our understanding of human evolution and have played a key role in the development of the field of palaeogenomics.
Article
Immunology
Wenji Liu, Jie Peng, Yixin Wu, Zuxiang Ye, Zhen Zong, Rui Wu, Hui Li
Summary: Gout is an autoimmune disease characterized by inflammation and damage to bone joints caused by the deposition of monosodium urate crystals. Research has uncovered the involvement of immune cells, inflammatory cytokines, and inflammasomes in gouty inflammation, providing insights into targeted therapy and further understanding the pathogenesis of gout.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Lisa K. Stamp, Hamish Farquhar, Huai Leng Pisaniello, Ana B. Vargas-Santos, Mark Fisher, David B. Mount, Hyon K. Choi, Robert Terkeltaub, Catherine L. Hill, Angelo L. Gaffo
Summary: The coexistence of gout and chronic kidney disease (CKD) is common, but there is a lack of quality evidence to guide gout management in CKD patients. This results in confusion among medical professionals about the appropriate management of gout and CKD patients.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Health Care Sciences & Services
Faven Butler, Ali Alghubayshi, Youssef Roman
Summary: Gout is an inflammatory condition caused by elevated serum urate, with different populations having varying levels of hyperuricemia and gout prevalence due to genetic variations in urate transporters. Asian populations (specifically CHS and JPT) have higher frequencies of urate-related risk alleles, possibly explaining the higher gout prevalence among Asians compared to Caucasians in healthcare settings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)