Article
Environmental Studies
Julie Ingram, Damian Maye, Clive Bailye, Andrew Barnes, Christopher Bear, Matthew Bell, David Cutress, Lynfa Davies, Auvikki de Boon, Liz Dinnie, Julian Gairdner, Caitlin Hafferty, Lewis Holloway, Daniel Kindred, David Kirby, Bethany Leake, Louise Manning, Ben Marchant, Aimee Morse, Simon Oxley, Martin Phillips, Aine Regan, Karen Rial-Lovera, David C. Rose, Juliette Schillings, Fiona Williams, Hefin Williams, Lucy Wilson
Summary: This study aims to identify key existing and emerging issues in digital agriculture and prioritize research questions through a participatory methodology. The study identifies 27 priority research questions across 7 themes and emphasizes the importance of value dimensions and social and institutional arrangements in supporting digital agriculture.
Review
Gastroenterology & Hepatology
Marlyn J. Mayo
Summary: The treatment for primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) may not be sufficient for all patients, and new approaches are needed. This review discusses potential therapeutic targets in PBC and provides examples of specific agents under development for the treatment of PBC, including targets related to bile, inflammation, cell survival, and fibrosis.
Article
Social Sciences, Interdisciplinary
Federica Lucivero, Nina Hallowell
Summary: The concept of 'digital phenotyping' originated in the mental health field and has since been adopted by other disciplines. Researchers working on two scientific projects at the University of Oxford's Big Data Institute are developing algorithmic phenotyping technologies, exploring the concepts of digital biomarkers and computational phenotyping. They analyze how these concepts are connected to research in digital phenotyping, comparing their epistemological and ethical implications, and highlighting the importance of distinguishing different meanings as the concept of digital phenotyping evolves.
BIG DATA & SOCIETY
(2021)
Review
Cell Biology
Prashanth Punyakoti, Tapan Behl, Aayush Sehgal, Shivam Yadav, Monika Sachdeva, Md. Khalid Anwer, Celia Vargas-De-La-Cruz, Thangavel Venkatachalam, Maaz Naqvi, Raman Verma, Hardeep Singh Tuli
Summary: Alzheimer's disease is a common neurodegenerative disorder, and its pathology is known. However, it is challenging to restore or prevent the progression of neurodegeneration and symptoms. Previous studies have explored antibody and small molecule-based approaches individually, but the combination of these two methods has not been attempted. This review discusses the potential mechanism of antibody-drug conjugates in mitigating Alzheimer's disease.
CELLULAR SIGNALLING
(2023)
Article
Clinical Neurology
Eduardo Benarroch
Summary: Pericytes play a critical role in the neurovascular unit (NVU) by interacting with endothelial cells, basal lamina, and glial cells, contributing to the maintenance of blood-brain barrier stability, regulation of capillary blood flow, angiogenesis, and immune responses. They also possess stem cell properties and can differentiate into smooth muscle, glial cells, or neurons. Dysfunction of pericytes is associated with various neurological disorders, including vascular disorders, Alzheimer's disease, traumatic injury, and multiple sclerosis, highlighting their potential as biomarkers and therapeutic targets for neuroprotection. Extensive reviews have been conducted on the functions and involvement of pericytes in neurological disorders.
Review
Clinical Neurology
Kateryna Antonenko, Maurizio Paciaroni, Larysa Sokolova, Francesca R. Pezzella
Summary: Digital health solutions in the field of stroke care are increasingly utilized across various domains, supporting professionals and patients in healthcare settings at all stages. These technologies play a crucial role in overcoming geographical and organizational barriers, providing utility at a low cost.
CURRENT OPINION IN NEUROLOGY
(2021)
Editorial Material
Clinical Neurology
Eduardo Benarroch
Summary: Zinc plays crucial roles in the developing and functioning of the nervous system through multiple mechanisms. The balance of zinc is essential for normal neuronal function, as both deficiency and excess can have harmful effects.
Review
Chemistry, Multidisciplinary
Daniela Mokra, Romana Barosova, Juraj Mokry
Summary: Sex-based differences in bronchial asthma are observed in childhood, with boys being more susceptible to allergic atopic asthma. In adulthood, women have a higher prevalence of asthma, especially the severe neutrophilic subtype associated with obesity. Sex steroids, such as estrogens, progesterone, and testosterone, play a role in these differences by exerting pro-inflammatory or anti-inflammatory effects. Other factors, including anatomical and physiological differences, genetics, obesity, lifestyle, smoking, and environmental factors, may also contribute to sex-based differences in asthma. Understanding these mechanisms can lead to more personalized asthma therapy. Articles from the English language PubMed database were reviewed for this study.
APPLIED SCIENCES-BASEL
(2023)
Review
Microbiology
Jose Antonio Vargas-Villavicencio, Irma Canedo-Solares, Dolores Correa
Summary: Diagnosis of acute Toxoplasma gondii infection is commonly done by detecting specific IgM antibodies. However, it has been observed that IgM antibodies decline slowly over time, which can last for months or even years. This phenomenon has raised concerns in terms of diagnostic accuracy and has prompted further investigation into the underlying biological mechanisms. Through a systematic comparison of research reports, it has been established that this phenomenon is widespread and may also occur in animals. Factors such as infection dynamics, parasite strain relevance, and host immune responses have been identified as potential causes for the prolonged IgM decay.
Article
Neurosciences
Laila Craighero, Umberto Granziol, Luisa Sartori
Summary: By observing someone's typing hands, an observer can determine whether the person is using their smartphone to obtain information or share it with others. The accuracy of this inference varies with age and typing style, and relies on the development of sensorimotor competence. This preliminary work could serve as a starting point for further research on sensorimotor representations of digital actions.
Article
Multidisciplinary Sciences
Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom
Summary: Long-acting glucagon analogue GCG104 causes weight loss in mice by direct receptor signaling at the level of the liver. Subtle changes in GCG104-sensitivity may alter its effects on metabolic parameters.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Julian Wienert, Tina Jahnel, Laura Maass
Summary: Digital public health is an emerging field that utilizes digitalization to improve public health, particularly in prevention and health promotion. This study aims to provide the first definition of digital public health interventions by merging models for public health functions, frameworks for digital health technologies, and a user-centered approach to intervention development. The study concludes that a digital public health intervention should address essential public health functions through digital means and involve the target group in the development process.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Multidisciplinary Sciences
Antoine Balzeau, Jean-Francois Mangin
Summary: The intersection of neuroscience and paleoanthropology provides insights into the morphology of the brain. Neuroimaging techniques help reveal the relationship between brain and endocast, and infer models of variability in brain morphology across different species.
Article
Business
Qinglan Liu, Adriana Hofmann Trevisan, Miying Yang, Janaina Mascarenhas
Summary: This study presents a systematic literature review to identify the critical functions of digital technologies in improving circular economy strategies. It proposes a framework to explain how these digital functions can enhance different circular economy strategies. The findings contribute to advancing the synergies between digital technologies and the circular economy paradigm.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Cecile Charle-Maachi, Alexandre Moreau-Gaudry, David Sainati, Dorothee Camus, Isabelle Adenot, Charles-Emmanuel Barthelemy, Thibault de Chalus, Frederique Debroucker, Fabrice Denis, Charlotte Gourio, Enguerrand Habran, Nadia Kamal, Yann-Mael Le Douarin, Arnaud Rosier, Stephane Schuck, Jean-Francois Thebaut, Anouk Trancart, Vincent Vercamer
Summary: Digital health is rapidly developing, bringing significant innovations to stakeholders in the healthcare system. However, challenges such as integration, value determination, and funding and evaluation methods need to be addressed. These digital solutions have great potential in improving healthcare systems and economic development.
Article
Neurosciences
Sylvain Rama, Norah Boumedine-Guignon, Marion Sangiardi, Fahamoe Youssouf, Yves Maulet, Christian Leveque, Maya Belghazi, Michael Seagar, Dominique Debanne, Oussama El Far
MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Dominique Debanne, Yanis Inglebert, Michael Russier
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Article
Behavioral Sciences
Dominique Debanne, Michael Russier
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Neurosciences
Mickael Zbili, Dominique Debanne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Correction
Neurosciences
Mickael Zbili, Dominique Debanne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Mickael Zbili, Sylvain Rama, Pierre Yger, Yanis Inglebert, Norah Boumedine-Guignon, Laure Fronzaroli-Moliniere, Romain Brette, Michael Russier, Dominique Debanne
Editorial Material
Neurosciences
Haruyuki Kamiya, Dominique Debanne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Yanis Inglebert, Johnatan Aljadeff, Nicolas Brunel, Dominique Debanne
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
Wei Zhang, Maria Ciorraga, Pablo Mendez, Diana Retana, Norah Boumedine-Guignon, Beatriz Achon, Michael Russier, Dominique Debanne, Juan Jose Garrido
Summary: The axon initial segment (AIS) is crucial for neuronal function, with the actin and microtubule cytoskeleton playing a key role in regulating AIS structure and function, and formins playing a critical role in maintaining AIS composition and stability.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Aurelie Fekete, Norbert Ankri, Romain Brette, Dominique Debanne
Summary: The distal shift of the axon initial segment (AIS) position increases axial resistance and excitability in L-5 pyramidal neurons, resulting in a decrease in the voltage threshold of the somatic action potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Salvatore Incontro, Malika Sammari, Fodil Azzaz, Yanis Inglebert, Norbert Ankri, Michael Russier, Jacques Fantini, Dominique Debanne
Summary: Research shows that Kv7 channel activity is upregulated in O-LM interneurons following induction of presynaptic long-term synaptic depression, leading to a synergistic long-term depression of intrinsic excitability. This process involves endocannabinoid biosynthesis and a persistent interaction with Kv7 channels.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Mael Dumenieu, Beatrice Marqueze-Pouey, Michael Russier, Dominique Debanne
Summary: Visual plasticity has been traditionally believed to take place in the primary and secondary cortical areas, while subcortical visual areas like the dLGN and SC were considered basic structures responsible for stable functions. However, recent findings indicate that neurons in these subcortical areas also exhibit functional plasticity, challenging our previous understanding and providing new insights into the visual system.
Article
Cell Biology
Johanna Extremet, Oussama El Far, Norbert Ankri, Sarosh R. Irani, Dominique Debanne, Michael Russier
Summary: Loss of function of LGI1 gene is associated with epileptic disorders, and patients with LGI1-directed autoantibodies have frequent focal seizures. LGI1 consists of Leucine-Rich Repeat (LRR) and Epitempin (EPTP) domains, which interact with transsynaptic complex at excitatory synapses. Specific LGI1-autoantibodies against LRR domain can modulate neuronal excitability, potentially accounting for the observed epileptiform activity in patients.
Article
Multidisciplinary Sciences
Mickael Zbili, Sylvain Rama, Maria-Jose Benitez, Laure Fronzaroli-Molinieres, Andrzej Bialowas, Norah Boumedine-Guignon, Juan Jose Garrido, Dominique Debanne
Summary: Blocking excitatory synaptic receptors leads to an increase in synaptic transmission and intrinsic excitability in the CA3 region, with intrinsic plasticity mediated by a reduction in Kv1.1 channel density. Activity-deprived neurons show down-regulation of axonal Kv1.1 channels, resulting in functional synergy between synaptic strength and intrinsic excitability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)