期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 12, 页码 812-822出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2924
关键词
-
资金
- National Institutes of Health (National Eye Institute) [R01EY003821]
- National Institute on Deafness and other Communication Disorders [R01DC000276, R01DC001508, P30 DC005211]
Sensory synapses of the visual and auditory systems must faithfully encode a wide dynamic range of graded signals, and must be capable of sustained transmitter release over long periods of time. Functionally and morphologically, these sensory synapses are unique: their active zones are specialized in several ways for sustained, rapid vesicle exocytosis, but their most striking feature is an organelle called the synaptic ribbon, which is a proteinaceous structure that extends into the cytoplasm at the active zone and tethers a large pool of releasable vesicles. But precisely how does the ribbon function to support tonic release at these synapses? Recent genetic and biophysical advances have begun to open the 'black box' of the synaptic ribbon with some surprising findings and promise to resolve its function in vision and hearing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据