期刊
NATURE REVIEWS NEUROSCIENCE
卷 9, 期 10, 页码 779-788出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2492
关键词
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资金
- National Research Centre for Growth and Development
- New Zealand Government Centre of Research Excellence
- Health Research Council
- Marsden Fund
- Alzheimer's Trust
- Coker Charitable Trust
- Lynette Sullivan Huntington's Disease Research Fund
High-content analysis (HCA) combines automated microscopy and automated image analysis to quantify complex cellular anatomy and biochemistry objectively, accurately and quickly. High-content assays that are applicable to neuroscience include those that can quantify various aspects of dendritic trees, protein aggregation, transcription factor translocation, neurotransmitter receptor internalization, neuron and synapse number, cell migration, proliferation and apoptosis. The data that are generated by HCA are rich and multiplexed. HCA thus provides a powerful high-throughput tool for neuroscientists.
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