Article
Medicine, General & Internal
Mateus Santana do Rosario, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Marco Antonio Caires Novaes, Marcos Vinicius Lima Oliveira Francisco, Cleiton Silva Santos, Daniel Moura, Fernanda Washington de M. Lima, Luiz Carlos Junior Alcantara, Isadora Cristina de Siqueira
Summary: This study reports on GBS and MFS cases associated with arboviruses during the Zika virus outbreak in Salvador, Brazil. The presence of multiple arboviral infections was found to be associated with GBS and MFS, highlighting the importance of diagnosis.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Ahsun Rizwan Siddiqi, Tehrim Khan, Muhammad Junaid Tahir, Muhammad Sohaib Asghar, Md. Saiful Islam, Zohaib Yousaf
Summary: This case report describes a rare case of Miller Fisher syndrome (MFS) occurring after COVID-19 vaccination and highlights the need for further research to establish a temporal association.
Article
Medicine, General & Internal
Boby Varkey Maramattom, Balram Rathish, Hanna A. Meleth
Summary: Miller Fischer syndrome is a rare variant of Guillain-Barre syndrome, characterized by a triad of ataxia, ophthalmoplegia, and areflexia, and is uncommonly associated with systemic illnesses. This article presents a case of MFS associated with typhoid fever, possibly the first report of such an association.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Yamato Nishiguchi, Hirofumi Matsuyama, Kuniko Maeda, Akihiro Shindo, Hidekazu Tomimoto
Summary: This case report describes a 71-year-old man who developed Miller Fisher syndrome (MFS) after receiving the BNT162b2 mRNA COVID-19 vaccine. More research is needed to establish the association between MFS and COVID-19 vaccines.
Review
Biotechnology & Applied Microbiology
Hao Liang, Yuanbo Cao, Wei Zhong, Zhenwang Ma, Jia Liu, Hong Chen
Summary: Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barre syndrome (GBS) that can occur after COVID-19 vaccination. This case report describes a 64-year-old Chinese man who developed MFS-GBS overlap syndrome 12 days after receiving the second dose of inactivated COVID-19 vaccine. The patient was successfully treated with intravenous immunoglobulin and acupuncture and made a complete recovery. Close monitoring of neurological complications following COVID-19 vaccination is important due to the potentially disabling and lethal effects.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Clinical Neurology
Susumu Kusunoki, Hugh J. Willison, Bart C. Jacobs
Summary: Guillain-Barre syndrome and Fisher syndrome are acute autoimmune neuropathies often triggered by infection, with antiglycolipid antibody titres elevated in acute-phase patients, particularly for diagnosis in FS. These antibodies are mainly found in acute motor axonal neuropathy GBS and FS, suggesting the need for further research and standardisation in antibody detection methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Hang Yu, Man Ding, Qian Cao, Rumeng Zhou, Jiajia Yao, Rong Fu, Yue Liu, Zheman Xiao, Zuneng Lu
Summary: This study aimed to investigate the clinical features of Miller Fisher syndrome (MFS) in southern China and compare them with those observed in other countries. The results showed that MFS patients in southern China were predominantly male and middle-aged, with most cases occurring in the winter and especially in the spring. More than half of the patients had clear precursor events, and the typical triad of ophthalmoplegia, ataxia, and areflexia was the most common presentation. Albuminocytological dissociation in cerebrospinal fluid (CSF) was observed in over 70% of patients. Nerve conduction studies (NCS) abnormalities were uncommon. Patients with incomplete ophthalmoplegia (IO) had an earlier onset age compared to those with complete ophthalmoplegia (CO), and bilateral symmetrical ophthalmoplegia was the most common symptom, with the external rectus muscle being the most frequently involved.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Ming Chi, Lu Han, Zilong Zhu
Summary: This article describes a 53-year-old woman who presented with acute bulbar palsy as the first symptom of overlapping MFS/GBS accompanied by severe headache. Early identification of these overlapping syndromes is important for the management of patients, to avoid respiratory failure or severe weakness with axonal degeneration.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Clinical Neurology
Jee-Eun Kim, Byeol-A Yoon, Yoo Hwan Kim, Jong Kuk Kim, Jong Seok Bae
Summary: This study aimed to identify and characterize Miller Fisher syndrome (MFS) following COVID-19 vaccination. The findings suggest that MFS following COVID-19 vaccination has different pathophysiology compared to MFS following COVID-19 infection and Guillain-Barre Syndrome (GBS) following COVID-19 vaccination. Considering the rare incidence and diagnostic challenges of this neurological syndrome, it should be recognized as an adverse event of COVID-19 vaccination.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Rehabilitation
Jill E. Mayer, Christine A. McNamara, John Mayer
Summary: This case report examined the effects of aquatic and land-based physiotherapy interventions on a patient with MFS-GBS and found that physiotherapy can improve functional outcomes in these patients, although some may require longer rehabilitation.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Immunology
Leona Moeller, Martina Kerwat, Lars Timmermann, Ole J. Simon
Summary: This case report presents a patient with an atypical Miller Fisher/Guillain-Barre-overlap-syndrome triggered by P. multocida infection, emphasizing the importance of considering this as a differential diagnosis for wound botulism.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.
Editorial Material
Clinical Neurology
Jonah P. Zuflacht, Aimee K. Boegle
Summary: CIDP may present acutely, resembling GBS.
Review
Clinical Neurology
Dorsa Alijanzadeh, Afsaneh Soltani, Fatemeh Afra, Fardis Salmanpour, Amir Hossein Loghman, Noosha Samieefar, Nima Rezaei
Summary: Miller Fisher syndrome (MFS) after COVID-19 immunization has favorable outcomes and good prognosis. However, more attention should be paid to MFS as an adverse effect of the vaccination. MFS should be considered in the differential diagnosis for patients with a history of recent COVID-19 vaccination and any of the ocular complaints, ataxia, or loss of reflexes, especially for male patients in their 60s and 70s.
Article
Clinical Neurology
Smriti Bose, Lay Khoon Loo, Yusuf A. Rajabally
Summary: Diagnostic delay in GBS is associated with patient-specific factors and patient pathways, with certain patient groups requiring a higher index of suspicion. Prospective studies are needed to further investigate this topic, with factors such as age, pre-existing conditions, and initial assessment contributing to delays in diagnosis and potential consequences.
Editorial Material
Clinical Neurology
Benjamin R. Wakerley, Mei Hong Tan, Martin R. Turner
Article
Clinical Neurology
Samuel Arends, Judith Drenthen, Peter van den Bergh, Hessel Franssen, Robert D. M. Hadden, Badrul Islam, Satoshi Kuwabara, Ricardo C. Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H. Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi-Chao Chao, Mazen M. Dimachkie, Ernesto A. Fulgenzi, Giuliana Galassi, Gerardo Gutierrez Gutierrez, Thomas Harbo, Hans-Peter Hartung, Sung-Tsang Hsieh, Lynette Kiers, Helmar C. Lehmann, Fiore Manganelli, Girolama A. Marfia, Giorgia Mataluni, Julio Pardo, Yann Pereon, Yusuf A. Rajabally, Lucio Santoro, Yukari Sekiguchi, Beth Stein, Mark Stettner, Antonino Uncini, Christine Verboon, Camiel Verhamme, Michal Vytopil, Waqar Waheed, Min Wang, Sasha Zivkovic, Bart C. Jacobs, David R. Cornblath
Summary: This study investigated the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barre syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). The results showed extensive variation in the clinical practice of EDx among IGOS centers across different regions. This diversity is likely to be present in other neuromuscular disorders and centers, emphasizing the need for standardization of EDx in future multinational GBS studies.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Alex Y. Doets, Hester F. Lingsma, Christa Walgaard, Badrul Islam, Nowshin Papri, Amy Davidson, Yuko Yamagishi, Susumu Kusunoki, Mazen M. Dimachkie, Waqar Waheed, Noah Kolb, Zhahirul Islam, Quazi Deen Mohammad, Thomas Harbo, Soren H. Sindrup, Govindsinh Chavada, Hugh J. Willison, Carlos Casasnovas, Kathleen Bateman, James A. L. Miller, Bianca van den Berg, Christine Verboon, Joyce Roodbol, Sonja E. Leonhard, Luana Benedetti, Satoshi Kuwabara, Peter Van den Bergh, Soledad Monges, Girolama A. Marfia, Nortina Shahrizaila, Giuliana Galassi, Yann Pereon, Jan Burmann, Krista Kuitwaard, Ruud P. Kleyweg, Cintia Marchesoni, Maria J. Sedano Tous, Luis Querol, Isabel Illa, Yuzhong Wang, Eduardo Nobile-Orazio, Simon Rinaldi, Angelo Schenone, Julio Pardo, Frederique H. Vermeij, Helmar C. Lehmann, Volkan Granit, Guido Cavaletti, Gerardo Gutierrez-Gutierrez, Fabio A. Barroso, Leo H. Visser, Hans D. Katzberg, Efthimios Dardiotis, Shahram Attarian, Anneke J. van der Kooi, Filip Eftimov, Paul W. Wirtz, Johnny P. A. Samijn, H. Jacobus Gilhuis, Robert D. M. Hadden, James K. L. Holt, Kazim A. Sheikh, Summer Karafiath, Michal Vytopil, Giovanni Antonini, Thomas E. Feasby, Catharina G. Faber, Cees J. Gijsbers, Mark Busby, Rhys C. Roberts, Nicholas J. Silvestri, Raffaella Fazio, Gert W. van Dijk, Marcel P. J. Garssen, Chiara S. M. Straathof, Kenneth C. Gorson, Bart C. Jacobs
Summary: The study validated the modified Erasmus GBS Outcome Score (mEGOS) for predicting walking ability in Guillain-Barre syndrome (GBS) patients internationally, and developed a region-specific version for patients in Europe and North America. The results showed that severe limb weakness and older age were the main predictors of poor outcomes.
Article
Clinical Neurology
Cheng-Yin Tan, Khean-Jin Goh, Ai-Wen Oh, Jerome Devaux, Nortina Shahrizaila
Summary: This study reported a cohort of patients with CIDP who had a prevalence of 8% of autoimmune nodopathies and poor response to IVIG treatment. Patients with IgG4 anti-NF155 and anti-CNTN1 antibodies showed similar clinical features and treatment responses as previous reports.
NEUROMUSCULAR DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Kee Huat Chuah, Carolyn Chue Wai Yim, Nur Adilah Abdul Aziz, Ee Chin Loh, David Paul Capelle, Nortina Shahrizaila, Alex Hwong Ruey Leow
Summary: This study compared the outcomes of ALS patients who underwent percutaneous endoscopic gastrostomy (PEG) placement with those who did not. The mortality rate at 6 and 12 months was slightly lower in the PEG cohort, but the difference was not statistically significant. Among the PEG cohort, 61% were considered high risk and 31% required long-term home noninvasive ventilation. All patients successfully underwent PEG insertion at single attempt.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Letter
Clinical Neurology
Cheng-Yin Tan, Tsun-Haw Toh, Yen-Fa Toh, Kum-Thong Wong, Nortina Shahrizaila, Khean-Jin Goh
Review
Clinical Neurology
Jee-Eun Kim, Byeol-A Yoon, Yoo Hwan Kim, Jong Kuk Kim, Jong Seok Bae
Summary: This study aimed to identify and characterize Miller Fisher syndrome (MFS) following COVID-19 vaccination. The findings suggest that MFS following COVID-19 vaccination has different pathophysiology compared to MFS following COVID-19 infection and Guillain-Barre Syndrome (GBS) following COVID-19 vaccination. Considering the rare incidence and diagnostic challenges of this neurological syndrome, it should be recognized as an adverse event of COVID-19 vaccination.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Letter
Clinical Neurology
Saro Kobayashi, Norito Kokubun, Reika Aoki, Mai Hamaguchi, Hadzki Matsuda, Keisuke Suzuki
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Samuel Arends, Judith Drenthen, Peter Y. K. van den Bergh, Robert D. M. Hadden, Nortina Shahrizaila, Mazen M. Dimachkie, Gerardo Gutierrez Gutierrez, Hans Katzberg, Lynette Kiers, Helmar C. Lehmann, Yann Pereon, Ricardo C. Reisin, Antonino Uncini, Camiel Verhamme, Wagar Waheed, David R. Cornblath, Bart C. Jacobs
Summary: This study investigated how neuromuscular EDx experts approach key aspects of GBS subtyping in practice and compared previously published EDx criteria for GBS. The study found extensive variability in the practical use of EDx criteria, potentially reducing the reproducibility of GBS subtyping.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Review
Neurosciences
Yoo-Hwan Kim, Jee-Eun Kim, Byeol-A Yoon, Jong-Kuk Kim, Jong-Seok Bae
Summary: Bilateral facial weakness with distal paresthesia (BFWdp) may be a variant of Guillain-Barre syndrome (GBS) following COVID-19 vaccination. This study found that BFWdp cases had similar characteristics to previous cases, but also showed additional features such as facial nerve enhancement on brain MRI and antiganglioside antibody positivity.
Article
Clinical Neurology
Tomoko Komagamine, Reika Aoki-Kawabata, Mai Hamaguchi, Keisuke Suzuki, Norito Kokubun
Summary: This study found that the maximum diameter of the interscalene gap was significantly larger in CIDP patients compared to patients with cervical spondylosis. It suggests that conventional cervical spine MRI can be used as a screening tool for nerve hypertrophy in CIDP.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Seon Min Yoon, Young Bum Park, Yousang Ko, Jong Seok Bae
Summary: This study aimed to investigate the initial trigger of peripheral neuropathies (PNs) in chronic obstructive pulmonary disease (COPD). The automated nerve excitability test (NET) was conducted on 20 COPD patients, and it was found that COPD patients exhibited abnormal nerve excitability, characterized by smaller threshold changes in the mid-depolarizing phase and a prominent superexcitability in the recovery cycle. There were no significant differences in sensory nerve excitability between COPD patients and control groups.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Ling Yi Lee, Cheng Yin Tan, Kum Thong Wong, Khean-Jin Goh, Nortina Shahrizaila
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Meeting Abstract
Clinical Neurology
Samuel Arends, Judith Drenthen, Peter Van den Bergh, Robert Hadden, Nortina Shahrizaila, Davide Binda, Thomas Brannagan, Carlos Casasnovas, Mazen Dimachkie, Ernesto Fulgenzi, Gerardo Gutierrez-Gutierrez, Sung-Tsang Hsieh, Hans Katzberg, Lynette Kiers, Helmar Lehmann, Girolama Marfia, Giorgia Mataluni, Julio Pardo-Fernandez, Yann Pereon, Yukari Sekiguchi, Antonino Uncini, Camiel Verhamme, Waqar Waheed, Min Wang, Bart Jacobs, David Cornblath
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Review
Neurosciences
Jonathan Cole, Anita Kamondi, Paulo Teixeira Kimaid, Nortina Shahrizaila
Summary: This paper presents the results of the first survey on training and education conducted by the regional chapters of the International Federation of Clinical Neurophysiology. The survey reveals significant differences in training durations and competency testing among different countries.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2022)
