Further insights into Alzheimer disease pathogenesis

In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention. Weiner, M. W. Nat. Rev. Neurol. 9, 65-66 (2013); published online 22 January 2013; doi:10.1038/nrneurol.2012.275