Immunotherapy for Alzheimer disease—the challenge of adverse effects

Modified Immunotherapies Against Alzheimer's Disease: Toward Safer and Effective Amyloid-β Clearance

(2017) Yan-Jiang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

Revised criteria for diagnosis of Alzheimer’s disease: National Institute on Aging-Alzheimer's Association diagnostic guidelines for Alzheimer's disease

(2011) Zaven S. Khachaturian   Alzheimers & Dementia

Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease

(2011) Bradley T. Hyman   ARCHIVES OF NEUROLOGY

Autoreactive-Aβ antibodies promote APP β-secretase processing

(2011) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Naturally Occurring Autoantibodies against  -Amyloid: Investigating Their Role in Transgenic Animal and In Vitro Models of Alzheimer's Disease

(2011) R. Dodel et al.   JOURNAL OF NEUROSCIENCE

p75NTR Regulates A  Deposition by Increasing A  Production But Inhibiting A  Aggregation with Its Extracellular Domain

(2011) Y.-J. Wang et al.   JOURNAL OF NEUROSCIENCE

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers

(2010) William D. Knight et al.   BRAIN

Immune responsiveness to inhaled antigens: local antibody production in the respiratory tract in health and lung diseases

(2010) Y. YOSHIZAWA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Conformations and Biological Activities of Amyloid Beta Peptide 25-35

(2010) L. Millucci et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Generation and Therapeutic Efficacy of Highly Oligomer-Specific  -Amyloid Antibodies

(2010) H. Hillen et al.   JOURNAL OF NEUROSCIENCE

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

APOE  4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics

(2009) D. Kaufer et al.   NEUROLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

P4-346: Safety, tolerability and biomarker effects of an Abeta monoclonal antibody administered to patients with Alzheimer's disease

(2008) Eric R. Siemers et al.   Alzheimers & Dementia

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Possible Involvement of Advanced Glycation End-Products (AGEs) in the Pathogenesis of Alzheimers Disease

(2008) Masayoshi Takeuchi et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammaging as a prodrome to Alzheimer's disease

(2008) Brian Giunta et al.   Journal of Neuroinflammation

Immunotherapy Reduces Vascular Amyloid-  in PDAPP Mice

(2008) S. Schroeter et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons

(2008) P.J. Shughrue et al.   NEUROBIOLOGY OF AGING