Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Petros Stathakos, Natalia Jimenez-Moreno, Lucy A. Crompton, Paul A. Nistor, Jennifer L. Badger, Peter A. Barbuti, Talitha L. Kerrigan, Andrew D. Randall, Maeve A. Caldwell, Jon D. Lane
Summary: Macroautophagy/autophagy cytoplasmic quality control pathways are crucial for neural development and maintaining functional neuronal populations in the adult brain. Declining neuronal autophagy pathways contribute to neurodegenerative diseases, including Parkinson's disease, highlighting the need for reliable human neuronal model systems for research and therapeutic interventions. HiPSC neural model systems show promise in meeting this demand but may face limitations in generating ventral midbrain dopaminergic neurons efficiently for functional and imaging-based in vitro assays.
Article
Biochemistry & Molecular Biology
Bok-Seok Kim, Taeik Jang, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim
Summary: The impairment of protein clearance mechanisms in dopaminergic neurons leads to the accumulation of alpha-synuclein, contributing to the pathogenesis of Parkinson's disease. Fas-associated factor 1 (FAF1) was found to disrupt alpha-synuclein clearance through the autophagy-lysosome pathway, indicating a novel role as a negative regulator of autophagic alpha-synuclein clearance. This disturbance ultimately leads to alpha-synuclein accumulation and autophagy dysregulation in PD model mice.
Article
Environmental Sciences
Yuri Lee, Sooji Choi, Kyung Won Kim
Summary: This study investigated the neurotoxic effects of the fungicide Dithianon and its underlying cellular and molecular mechanisms using the model organism Caenorhabditis elegans. Chronic exposure to Dithianon caused significant degeneration of dopaminergic neurons in a concentration-dependent manner. The study also found that Dithianon induced oxidative stress and mitochondrial fragmentation, which are associated with cellular stress. These findings contribute to a better understanding of the neurotoxic potential of Dithianon.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Choi
Summary: The Tat-AR protein showed protective effects against MPP+-induced cell death in SH-SY5Y cells and inhibited dopaminergic neuronal cell death in a mouse model of PD. These findings suggest that Tat-AR may be a useful therapeutic protein for Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Qiong Liu, Juan Chen, Jin Xue, Xun Zhou, Yun Tian, Qiao Xiao, Wen Huang, Yongcheng Pan, Xiaoxia Zhou, Jian Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Runcheng He, Yaqin Xiang, Tian Tu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Lu Shen, Ranhui Duan, Beisha Tang, Zhenhua Liu
Summary: This study demonstrates the association between GGC repeat expansions within NOTCH2NLC and the pathogenesis of Parkinson's disease, leading to degeneration of nigral dopaminergic neurons.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin
Summary: In this study, a mouse maternal infection model was used to investigate the impact of maternal herpesvirus infection on the development and physiology of midbrain dopaminergic neurons in adult offspring. The results suggested that maternal infection with Herpesviridae, specifically MHV68, can trigger changes in midbrain development that affect dopamine neuron physiology in adulthood. This study is important for understanding the neuronal susceptibility underlying neurodegenerative diseases, particularly Parkinson's disease.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Illyane Sofia Lima, Ana Catarina Pego, Joao Tomas Barros, Ana Rita Prada, Raffaella Gozzelino
Summary: There is currently no cure for neurodegenerative diseases like Parkinson's disease. The progression of PD is significantly contributed by apoptosis, necroptosis, and ferroptosis, which may correlate to different disease stages and symptom severities. The efficacy of therapeutic approaches against neuronal death in PD might depend on the death program they target and its relevance to a specific phase of the disease.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Erika da Cruz Guedes, Adolfo Garcia Erustes, Anderson H. F. F. Leao, Cesar Alves Carneiro, Vanessa C. Abilio, Antonio W. Zuardi, Jaime Eduardo C. Hallak, Jose Alexandre Crippa, Claudia Bincoletto, Soraya S. Smaili, Patricia Reckziegel, Gustavo J. S. Pereira
Summary: In this study, the potential neuroprotective effect of cannabidiol (CBD) in the treatment of Parkinson's Disease (PD) was evaluated using a C. elegans model. The results showed that CBD could reverse locomotor alterations induced by reserpine and protect neurons from degeneration. Additionally, CBD also reduced the formation of reactive oxygen species (ROS) and accumulation of alpha-synuclein protein. These findings indicate that CBD acts as a neuroprotector in dopaminergic neurons and highlights its potential in the treatment of PD.
NEUROCHEMICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Jeong Won Lee, Yoo Sung Song, Hyeyun Kim, Bon D. Ku, Won Woo Lee
Summary: The rate of dopaminergic denervation in Parkinson's disease was estimated using imaging studies in a large prospective cohort, revealing a relatively weak association between dopaminergic denervation and age or symptom duration, as compared to previous knowledge. Different age onsets in patients did not show significant correlations between symptom durations and striatal specific binding ratios.
Article
Clinical Neurology
Or Koren, Ronny P. Bartsch, Zoya Katzir, Uri Rosenblum, Sharon Hassin-Baer, Rivka Inzelberg, Meir Plotnik
Summary: This study aimed to investigate the relationship between increased interhemispheric cortical synchronization and dopamine deficiency in Parkinson's disease (PD), and its correlation with motor function. The results showed that PD patients exhibit higher interhemispheric cortical synchronization during the OFF state compared to the ON state, and this increase is associated with clinical improvement. These findings may reflect neural processes related to asymmetric subcortical dopamine deficiency.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Rafael Franco, Rafael Rivas-Santisteban, Gemma Navarro, Annalisa Pinna, Irene Reyes-Resina
Summary: This paper explores the potential mechanisms of dopaminergic denervation in Parkinson's disease by studying genes related to familial cases. It proposes that gene mutations can alter the processing of alpha-synuclein or disrupt vesicular trafficking and protein processing mechanisms. Mitochondria play a central role in both pathways, suggesting that targeting G protein-coupled receptors in neurons' mitochondria may lead to new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Leilei Chen, Yujv Huang, Xing Yu, Jiahong Lu, Wenting Jia, Juxian Song, Liangfeng Liu, Youcui Wang, Yingyu Huang, Junxia Xie, Min Li
Summary: Cory from Uncaria rhynchophylla has been shown to exhibit neuroprotective effects in rotenone-induced PD animal models by reducing neuroinflammation and diminishing alpha-synuclein aggregates through various pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Jorge L. Zeredo, Shaun K. L. Quah, Chloe U. Wallis, Laith Alexander, Gemma J. Cockcroft, Andrea M. Santangelo, Jing Xia, Yoshiro Shiba, Jeffrey W. Dalley, Rudolf N. Cardinal, Angela C. Roberts, Hannah F. Clarke
JOURNAL OF NEUROSCIENCE
(2019)
Review
Biology
Jeffrey W. Dalley, Karen D. Ersche
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Letter
Clinical Neurology
Chencheng Zhang, Kaiwen Zhu, Dianyou Li, Valerie Voon, Bomin Sun
Editorial Material
Neurosciences
Chiara Giuliano, Jeffrey W. Dalley
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Alekhya Mandali, Arjun Sethi, Mara Cercignani, Neil A. Harrison, Valerie Voon
Summary: Risk evaluation plays a crucial role in decision making, and this study examines the impact of Methylphenidate on ADHD patients' risk attitudes. The findings suggest that ADHD patients have a bias towards risky choices and Methylphenidate enhances this preference, particularly in the patient group. These results have implications for understanding the differential effects of Methylphenidate on ADHD compared to the healthy population.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Jolyon A. Jones, Katharina Zuhlsdorff, Jeffrey W. Dalley
Summary: Drug addiction is manifested in some individuals and involves multifaceted processes such as cognitive control failures. Impulsivity, which includes reckless behavior without foresight, underlies most drug-taking behavior. While the neural substrates of the relationship between trait impulsivity and drug compulsion are poorly understood, advances have been made in studying limbic cortico-striatal circuits and neuromodulatory influences.
JOURNAL OF NEUROCHEMISTRY
(2021)
Letter
Clinical Neurology
Alekhya Mandali, Kosuke Tsurumi, Traian Popa, Valerie Voon
Editorial Material
Neurosciences
Valerie Voon
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Review
Biochemistry & Molecular Biology
Tun-Pin Hsueh, Wan-Ling Lin, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: Artemisia capillaris, also known as Yin-Chen in Chinese, is a traditional medicinal herb with a wide range of pharmacological properties, including effects on liver function and treatment of liver diseases. The bioactive compounds in this herb exhibit antioxidant, anti-inflammatory, and antiviral properties, with chlorogenic acid having a relatively long half-life. Careful consideration of dosing schedules is important for maximizing therapeutic outcomes and minimizing potential side effects when using this herb for various diseases.
Article
Plant Sciences
Jung-Hung Chen, I-Hsin Lin, Thomas Y. Hsueh, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study aimed to investigate the metabolism, distribution, and transplacental transfer mechanism of codeine and its metabolites in pregnant rats, as well as to assess the risk of medication for pregnant women.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valtteri Kaasinen, Emma A. Honkanen, Kari Lindholm, Elina Jaakkola, Joonas Majuri, Riitta Parkkola, Tommi Noponen, Tero Vahlberg, Valerie Voon, Luke Clark, Juho Joutsa, Marko Seppanen
Summary: Gambling disorder is a major public health issue, and it shares similarities with substance use disorders in terms of the role of brain monoamines in addiction susceptibility and outcome. The study used [I-123]FP-CIT SPECT imaging to assess the roles of striatal dopamine transporter binding and extrastriatal serotonin transporter binding in gambling disorder, and found that patients with gambling disorder had higher impulsivity scores and higher binding in the ventromedial prefrontal cortex, likely reflecting serotonin transporter activity.
Article
Neurosciences
Katharina Zuhlsdorff, Jeffrey W. Dalley, Trevor W. Robbins, Sharon Morein-Zamir
Summary: Behavioral and cognitive flexibility enable individuals to adapt to a changing environment. This study introduces a novel "change your mind task" to assess volitional switching under uncertainty, without the need for rule-based learning. The findings suggest that individuals are more likely to change their response when the feedback is negative or when their initial response is incorrect.
Review
Neurosciences
Olivia Stupart, Trevor W. Robbins, Jeffrey W. Dalley
Summary: The meta-analysis showed that unconditioned tasks are generally poor at consistently demonstrating differences between control and separated groups in rats, indicating the need for more objective tasks in translational research on stress-related disorders.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Yi-Jie Zhao, Yingying Zhang, Qianfeng Wang, Luis Manssuer, Hailun Cui, Qiong Ding, Bomin Sun, Wenjuan Liu, Valerie Voon
Summary: This study reveals impairments in uncertainty processing in obsessive-compulsive disorder, especially in more certain trials. It also indicates that neural differentiation of high and low uncertainty is compromised and uncertainty processing may be a trait cognitive endophenotype. This has important implications for the treatment and management of individuals with OCD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Clinical Neurology
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon
Summary: This study evaluated the subacute effect of bilateral ventral subthalamic nucleus stimulation at 10Hz on emotional processing in Parkinson's disease patients. The results showed that 10Hz stimulation increased arousal ratings in patients with higher depression scores and induced a positive shift in valence ratings to negative emotional stimuli in patients with lower apathy scores. In contrast, 130Hz stimulation led to reduced arousal ratings in all patients and more positive valence ratings in patients with higher apathy scores.
