Review
Biochemistry & Molecular Biology
Lola Ugalde-Trivino, Margarita Diaz-Guerra
Summary: Recent research has shown that targeting PSD-95 may be an effective strategy for protecting neurons in cases of stroke. Two different therapeutic approaches using cell penetrating peptides have been developed and advanced to clinical stages. A third peptide has also been developed to interfere with PSD-95 cleavage, reducing neuronal death and improving outcomes in preclinical models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Hu Lv, Ying Li, Qian Cheng, Jiawei Chen, Wei Chen
Summary: Numerous evidences have shown the neuroprotective role of DEX against cerebral ischemic injury by modulating the expression of HDAC5, NPAS4, MDM2, and PSD-95, impacting cell survival and apoptosis. DEX intervenes in MDM2-induced PSD-95 ubiquitination and degradation through its effects on HDAC5 and NPAS4.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Javier R. Balboa, Dominik J. Essig, Sana Ma, Nichlas Karer, Louise S. Clemmensen, Soren W. Pedersen, Andreas C. Joerger, Stefan Knapp, Soren Ostergaard, Kristian Stromgaard
Summary: The complex of NMDAR, nNOS, and PSD-95 is an important therapeutic target for acute ischemic stroke. By designing a cyclic nNOS β-hairpin mimetic peptide and generating peptide arrays, a potent inhibitor of the nNOS/PSD-95 interaction was identified.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Lores-Arnaiz, Analia G. Karadayian, Alicia Gutnisky, Jennifer Miranda, Georgina Rodriguez de Lores Arnaiz
Summary: Nitric oxide generation is closely related to the activity of certain proteins at synaptic sites. Administration of levocabastine in rats can alter the expression of synaptic proteins and mitochondrial function, ultimately affecting the functional interaction between different proteins and NO synthesis. Levocabastine-induced alterations in synaptic proteins and mitochondrial bioenergetics may play a significant role in the regulation of NO synthesis.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Madiha Rasheed, Han Wang, Chaolei Wang, Jingyan Sun, Zixuan Chen, Yulin Deng
Summary: Depression in astronauts is a consequence of space flight, negatively affecting their work performances. In this study, we investigated the potential role of miR-445-3p in regulating the NR2B-PSD-95-nNOS complex and preventing neuron damage associated with depression induced by space flight.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Cell Biology
Anagh Sinha Ravi, Menglong Zeng, Xudong Chen, Gerardo Sandoval, Javier Diaz-Alonso, Mingjie Zhang, Roger A. Nicoll
Summary: Recent research suggests that the TARP/PSD-95 complex is an essential interaction underlying AMPAR trafficking and LTP. The interaction between PSD-95 and AMPAR auxiliary subunits TARPs can capture AMPARs and enhance synaptic transmission and LTP.
Review
Pharmacology & Pharmacy
Qian Xie, Hongyan Li, Danni Lu, Jianmei Yuan, Rong Ma, Jinxiu Li, Mihong Ren, Yong Li, Hai Chen, Jian Wang, Daoyin Gong
Summary: Natural products play a significant role in disease prevention and health promotion, especially for stroke. They modulate activities through multiple targets and signaling pathways for neuroprotection, making them suitable candidates for stroke treatment. Further exploration is needed to understand the structure-activity relationship of natural products in neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siqi Wang, Yuting Chen, Chen Xia, Chunyan Yang, Jian Chen, Li Hai, Yong Wu, Zhongzheng Yang
Summary: Glycosylated quercetin (2Glu-Que) significantly enhances the neuroprotective effects of quercetin by improving water solubility, stability, and cell viability, making it a promising candidate in neuroprotection.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Mario J. Bertogliat, Raghu Vemuganti
Summary: The study demonstrates that TET3 plays a role in ischemic neuroprotection by regulating the levels of 5hmC at gene promoter regions, modulating multiple neuroprotective pathways, and potentially improving outcomes following ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Wei Wei, Weili Liu, Shibin Du, Gokulapriya Govindarajalu, Antony Irungu, Alex Bekker, Yuan-Xiang Tao
Summary: The study demonstrated that ZL006-05 has a significant alleviating effect on cancer pain and chemotherapy-induced neuropathic pain, reducing pain sensitivity and neuronal/astrocyte hyperactivities.
Article
Biochemistry & Molecular Biology
Katarzyna Stachowicz
Summary: PSD-95 is a crucial component of excitatory synapses and plays a role in synaptic plasticity. Its involvement in the side effects of antidepressants related to cognitive function and psychosis is being explored. Understanding the mechanisms of action of compounds with antidepressant potential, such as PSD-95, can aid in the development of safer drugs.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rong Ma, Qian Xie, Hongyan Li, Xiaoqing Guo, Jian Wang, Yong Li, Mihong Ren, Daoyin Gong, Tian Gao
Summary: L-borneol can improve neurological deficits, reduce cerebral infarction, and promote angiogenesis by increasing levels of Ang-1 and VEGF, while also promoting neurogenesis, as well as affecting the expression of VEGF, BDNF, TGF-beta 1, and MMP9 to play a neuroprotective role in cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Zeeshan Ahmad Khan, Dewan Md Sumsuzzman, Jeonghyun Choi, George Kamenos, Yonggeun Hong
Summary: Poly I:C exerts neuroprotective effects against cerebral ischemia by activating the TLR3/NF-kappa B/TNF-alpha pathway, and suppressing TLR2/4 may provide neuroprotection against ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)