Review
Neurosciences
Qi-Hao Yang, Yong-Hui Zhang, Shu-Hao Du, Yu-Chen Wang, Yu Fang, Xue-Qiang Wang
Summary: The research and clinical application of noninvasive brain stimulation in treating neuropathic pain are increasing. This review article outlines the effectiveness and limitations of the noninvasive brain stimulation approach in treating central neuropathic pain. It summarizes the research progress and effects of different noninvasive brain stimulation methods on central neuropathic pain. However, the optimal stimulation targets, intensity, and time for each type of central neuropathic pain using transcranial direct current stimulation are still difficult to identify.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Anesthesiology
Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern, Danielle M. Santarelli
Summary: Ambroxol is a versatile drug with multiple therapeutic actions, including mucoactive, secretolytic, anti-inflammatory, antioxidant, and local anesthetic properties. It has a long history of use in respiratory diseases and has shown efficacy in relieving sore throat. Recent research has focused on its potential for neuropathic pain treatment, despite slow progress. Ambroxol is an inhibitor of Na(v)1.8, an important player in neuropathic pain, and Na(v)1.7, a promising target for chronic pain treatment. This review discusses its analgesic mechanisms, synergistic properties, preclinical and clinical results in managing persistent pain and neuropathic pain symptoms. It is a safe drug with extensive data, encouraging further investigation for repurposing, and urging the pharmaceutical industry to develop optimized formulations for neuropathic pain.
Article
Medicine, Research & Experimental
Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones, Keyoumars Ashkan
Summary: This study reported a rare case of central itch syndrome following thalamic deep brain stimulation, where the patient experienced severe itching after the procedure. Evaluation ruled out common causes of the rash and a trial of stimulation adjustment showed improvement in the itching symptoms. Precise imaging suggested the lateral portion of the ventral posterolateral and posteroinferior nuclei of the thalamus as critical in the neurophysiology of itch in humans.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Ancor Serrano Afonso, Thiago Carnaval, Sebastia Videla Ces
Summary: Despite the widespread adoption of multimodal analgesic treatment for neuropathic pain, there is still a lack of sufficient high-quality evidence regarding its effectiveness, tolerability, and safety. While recent research has attempted to provide new insights into this area, the overall quality of evidence has not shown significant improvement in recent years.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Damiana Scuteri, Kengo Hamamura, Tsukasa Sakurada, Chizuko Watanabe, Shinobu Sakurada, Luigi Antonio Morrone, Laura Rombola, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corasaniti
Summary: This study investigated the analgesic properties of essential oils in mice experimental models, with majority of studies focusing on acute nociceptive pain models. The findings suggest that essential oils show efficacy in reducing acute pain, but have limited results in neuropathic pain models, highlighting the need for further research to validate their effectiveness for clinical translation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Erliang Kong, Yongchang Li, Mengqiu Deng, Tong Hua, Mei Yang, Jian Li, Xudong Feng, Hongbin Yuan
Summary: Neuropathic pain is characterized by hyperalgesia and allodynia. Inflammation plays a role in the development of neuropathic pain, affecting synaptic transmission and regulated by glial cells. Glycometabolism reprogramming in inflammatory cells, specifically impaired oxidative phosphorylation and enhanced glycolysis, promotes neural inflammation in peripheral and central nervous system. Further research is needed to explore the role of glycometabolism in glial cells in neuropathic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Mengmeng Zhou, Qingxiang Zhang, Mingzhu Huo, Huijun Song, Hongen Chang, Jiaojiao Cao, Yuxin Fang, Di Zhang
Summary: Nociceptive signaling responses to painful stimuli are transmitted to the central nervous system (CNS) from the afferent nerves of the periphery. Electroacupuncture (EA) is a widely used pain management strategy that can alleviate neuropathic pain in the CNS. This review discusses the mechanisms and pathways, such as serotonin/norepinephrine, endogenous opioid, endogenous cannabinoid, amino acid neurotransmitter, and purinergic pathways, through which EA can provide analgesic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Ellane Barcelon, Seohyun Chung, Jaesung Lee, Sung Joong Lee
Summary: It has been found that men and women have different levels of susceptibility to chronic pain. Increasing number of studies have identified factors and mechanisms underlying sex differences in pain sensitization. This review discusses sexually dimorphic pain phenotypes in various animal models, factors involved, and potential mechanisms for the sexual dimorphism in pain sensitization.
Review
Biochemistry & Molecular Biology
Bei Tan, Xueqing Wu, Jie Yu, Zhong Chen
Summary: Neuropathic pain is a chronic condition that affects the body function and quality of life of patients. Current clinical medications for the treatment of neuropathic pain often have limited efficacy and significant side effects. Saponins, as bioactive components extracted from Chinese herbal medicine, have shown analgesic effects in animal models. This review summarizes the latest information on the analgesic effects of saponins in neuropathic pain and explores the potential mechanisms of action.
Review
Pharmacology & Pharmacy
Clayton Culp, Hee Kee Kim, Salahadin Abdi
Summary: Ketamine has shown promising effectiveness in treating chronic pain, especially cancer-related neuropathic pain. It has the potential to reduce opioid use and exhibits improved safety profiles at sub-anesthetic concentrations.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
D. Scuteri, L. Rombola, K. Hamamura, T. Sakurada, C. Watanabe, S. Sakurada, F. Guida, S. Boccella, S. Maione, G. Gallo Afflitto, C. Nucci, P. Tonin, G. Bagetta, M. T. Corasaniti
Summary: This systematic review investigates the efficacy of cannabinoids in ocular pain treatment, demonstrating potential analgesic and anti-inflammatory effects. However, limited studies and methodological issues raise concerns regarding bias and generalizability. Further preclinical studies are needed to explore the therapeutic potential of cannabinoids in ocular pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Geriatrics & Gerontology
Jing Luo, Hui-Qi Zhu, Bo Gou, Yi-Li Zheng
Summary: Diabetic neuropathic pain (DNP) is a common disease with high incidence worldwide. Drug therapy, although commonly used, has various side effects, leading to increased interest in exercise therapy. Understanding the mechanisms of exercise therapy for DNP is important in selecting appropriate treatment methods due to the unclear pathological mechanism of DNP.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Calogero Malfitano, Angela Rossetti, Stefano Scarano, Chiara Malloggi, Luigi Tesio
Summary: In this study, a patient with thalamic stroke and pain symptoms showed improvement in pain and paresthesia after receiving rTMS treatment. The recovery in motor cortex excitability of the affected hemisphere was associated with the clinical improvement in this central post-stroke pain case.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Pingchuan Ma, Rufan Mo, Huabao Liao, Chengjie Qiu, Genhao Wu, Caixia Yang, Yunxiao Zhang, Yiran Zhao, Xue-Jun Song
Summary: This study demonstrates the distinct roles of gut microbiota in chronic painful conditions caused by nerve injury, chemotherapy, and diabetic neuropathy. Depletion of gut microbiota can prevent or suppress the occurrence of these painful syndromes, and fecal bacteria transplantation can partially restore gut microbiota and fully alleviate the pain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Margot Geerts, Mike Oakes, Tim J. E. Church, Stephen G. Waxman, Sulayman D. Dib-Hajj, Catharina G. Faber, Ingemar S. J. Merkies
Article
Neurosciences
Ivo Eijkenboom, Maurice Sopacua, Auke B. C. Otten, Monique M. Gerrits, Janneke G. J. Hoeijmakers, Stephen G. Waxman, Raffaella Lombardi, Giuseppe Lauria, Ingemar S. J. Merkies, Hubert J. M. Smeets, Catharina G. Faber, Jo M. Vanoevelen
EXPERIMENTAL NEUROLOGY
(2019)
Article
Clinical Neurology
Ivo Eijkenboom, Maurice Sopacua, Janneke G. J. Hoeijmakers, Bianca T. A. de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J. M. Smeets, Stephen G. Waxman, Giuseppe Lauria, Ingemar S. J. Merkies, Catharina G. Faber, Monique M. Gerrits
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Malgorzata A. Mis, yang Yang, Brian S. Tanaka, Karolina Gomis-Perez, Shujun Liu, Fadia Dib-Hajj, Talia Adi, Rolando Garcia-Milian, Betsy R. Schulman, Sulayman D. Dib-Hajj, Stephen G. Waxman
JOURNAL OF NEUROSCIENCE
(2019)
Review
Pediatrics
Luke Arthur, Kirsty Keen, Madeleine Verriotis, Judy Peters, Alison Kelly, Richard F. Howard, Sulayman D. Dib-Hajj, Stephen G. Waxman, Suellen M. Walker
JOURNAL OF PEDIATRICS
(2019)
Review
Clinical Neurology
Maurice Sopacua, Janneke G. J. Hoeijmakers, Ingemar S. J. Merkies, Giuseppe Lauria, Stephen G. Waxman, Catharina G. Faber
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Editorial Material
Neurosciences
Stephen G. Waxman, Sulayman D. Dib-Hajj
Article
Neurosciences
Mathilde R. Israel, Brian S. Tanaka, Joel Castro, Panumart Thongyoo, Samuel D. Robinson, Peng Zhao, Jennifer R. Deuis, David J. Craik, Thomas Durek, Stuart M. Brierley, Stephen G. Waxman, Sulayman D. Dib-Hajj, Irina Vetter
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Multidisciplinary Sciences
Zvonimir Vrselja, Stefano G. Daniele, John Silbereis, Francesca Talpo, Yury M. Morozov, Andre M. M. Sousa, Brian S. Tanaka, Mario Skarica, Mihovil Pletikos, Navjot Kaur, Zhen W. Zhuang, Zhao Liu, Rafeed Alkawadri, Albert J. Sinusas, Stephen R. Latham, Stephen G. Waxman, Nenad Sestan
Editorial Material
Anesthesiology
Stephen G. Waxman
Review
Anesthesiology
Stephen G. Waxman
Article
Neurosciences
Jianying Huang, Mark Estacion, Peng Zhao, Fadia B. Dib-Hajj, Betsy Schulman, Angela Abicht, Ingo Kurth, Knut Brockmann, Stephen G. Waxman, Sulayman D. Dib-Hajj
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
N. Bonner, S. Bozzi, L. Morgan, B. Mason, M. J. Peterschmitt, T. Z. Fischer, R. Arbuckle, M. Reaney
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2020)