期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 14, 期 2, 页码 113-119出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3510
关键词
-
类别
资金
- US National Institutes of Health (NIH) [R01-HL083464, P30-AR061303]
- Muscular Dystrophy Association
Correct specification of myofilament length is essential for efficient skeletal muscle contraction. The length of thin actin filaments can be explained by a novel 'two-segment' model, wherein the thin filaments consist of two concatenated segments, which are of either constant or variable length. This is in contrast to the classic 'nebulin ruler' model, which postulates that thin filaments are uniform structures, the lengths of which are dictated by nebulin. The two-segment model implicates position-specific microregulation of actin dynamics as a general principle underlying actin filament length and stability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据