Article
Microbiology
Nana Wei, Jinmiao Lu, Yi Dong, Shibo Li
Summary: This study investigated the microbial community and antibiotic resistome in wild tick species. The results showed that the microbial composition is variable, with Proteobacteria and Bacteroidetes being the dominant phyla. A total of 100 different antibiotic resistance genes (ARGs) across 12 antibiotic classes were identified, with aminoglycosides, multidrug, macrolide-clinolamide-streptogramin B, and tetracycline resistance genes being the most dominant. Network analysis revealed potential host genera for different ARGs. This study provides a comprehensive overview of the diversity and abundance of ARGs in wild ticks, highlighting their potential role as disseminators of ARGs into the environment and vertebrate hosts.
Article
Infectious Diseases
Juan Alberto Guevara Salazar, Jessica Rubi Moran Diaz, Enrique Ramirez Segura, Jose Guadalupe Trujillo Ferrara
Summary: The development of multi-drug resistance in Mycobacterium tuberculosis is a gradual process involving genetic mutations and environmental pressures. Therefore, treating microbial infections with low mutagenic antibiotics and resistance inhibitors is crucial to combat resistance.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Environmental Sciences
Ruijie Zhang, Xuming Xu, Dantong Jia, Yitao Lyu, Jingrun Hu, Qian Chen, Weiling Sun
Summary: This study found that antibiotics inhibit denitrification, but sediments help alleviate this inhibition and promote bacterial growth. Sediments have negative effects on antibiotic resistance genes but positive effects on bacterial quantity and denitrification functional genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Okugbe Ebiotubo Ohore, Yuwen Wang, Yunjie Wei, Edmond Sanganyado, Muhammad Shafiq, Xiaoyang Jiao, Wenhua Liu, Amechi S. Nwankwegu, Zhen Wang
Summary: This study investigated the molecular mechanisms of phylogenetic turnover in microbial communities and the impact of antibiotics and antibiotic resistance genes (ARGs) on microbial assemblages. The research found that increased concentrations of antibiotics in ecosystems can stimulate the proliferation of ARGs, potentially affecting the assembly of microbial communities. Additionally, the study revealed complex interrelationships between ARGs and microbial communities, with arthropods and nematodes showing the strongest potential for acquiring ARGs.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Spectroscopy
Joshua C. Gukowsky, Lili He
Summary: This study evaluated the antibiotic response patterns observed in liquid samples from E. coli under different conditions and found that the experimental procedure significantly impacts the resulting SERS signals. The target patterns could only be observed when the bacteria were washed with water and incubated with antibiotics in a nutrient-rich growth medium. These findings can improve existing methods for testing antibiotic responses using SERS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Food Science & Technology
Monika Krahulcova, Barbora Micajova, Petra Olejnikova, Klara Cverenkarova, Lucia Birosova
Summary: Among consumers in Slovakia, smoothies are becoming increasingly popular and their microbiological safety depends on hygiene standards. Antibiotic-resistant bacteria were found in at least one fresh bar in the sampled smoothies, with coliform bacteria prevailing, particularly in green smoothies or juices with more vegetable ingredients. The most effective way to decrease bacterial counts in the final product was found to be washing ingredients with a biocide agent containing silver and hydrogen peroxide.
Article
Gastroenterology & Hepatology
Fergus W. J. Collins, Calum J. Walsh, Beatriz Gomez-Sala, Elena Guijarro-Garcia, David Stokes, Klara B. Jakobsdottir, Kristjan Kristjansson, Finlay Burns, Paul D. Cotter, Mary C. Rea, Colin Hill, R. Paul Ross
Summary: Shotgun metagenomic sequencing of the intestinal microbiome of 32 species of deep-sea fish across the Atlantic Ocean revealed extensive differences from previously identified microbes in reference databases. The constructed metagenome-assembled genomes (MAGs) demonstrate how these microbes have adapted to deep-sea life, with almost complete lack of acquired resistance genes to known antibiotics in many samples.
Review
Biochemistry & Molecular Biology
Giada Cernicchi, Tommaso Felicetti, Stefano Sabatini
Summary: AMR is a complex threat to human health, and blocking bacterial resistance mechanisms is a hot topic in drug discovery. By designing and synthesizing novel EPIs, researchers aim to discover more effective microbial EPIs with improved safety profiles.
Editorial Material
Multidisciplinary Sciences
Conrad O. Iyegbe, Paul F. O'Reilly
Summary: Rare and common genetic variants associated with schizophrenia provide convergent clues about the underlying biology of this complex disorder.
Review
Biochemistry & Molecular Biology
Adriana Aurelia Chis, Luca Liviu Rus, Claudiu Morgovan, Anca Maria Arseniu, Adina Frum, Andreea Loredana Vonica-Tincu, Felicia Gabriela Gligor, Maria Lucia Muresan, Carmen Maximiliana Dobrea
Summary: The effectiveness of antibiotics is severely impacted by antimicrobial resistance, with multidrug-resistant pathogens being a major public health concern. The main mechanisms by which bacteria develop resistance to antibiotics include altering drug targets, preventing drug entry into cells, efflux pumps, or drug inactivation. Understanding and predicting resistance patterns can lead to better selection of active antibiotics for treating multidrug-resistant infections.
Article
Environmental Sciences
Danyan Qiu, Mingjing Ke, Qi Zhang, Fan Zhang, Tao Lu, Liwei Sun, Haifeng Qian
Summary: Non-antibiotic stressors significantly contribute to the evolution of bacterial antibiotic resistance. Pesticides affect the acquisition and transmission of antibiotic resistance genes in bacteria through mechanisms such as activating efflux pumps, inhibiting outer membrane pores, and inducing gene mutations. Horizontal gene transfer is a major mechanism by which pesticides influence the spread of antibiotic resistance genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Zhen Bi, Ge Song, Xiaoming Sun
Summary: The responses of anammox consortia to antibiotics SDZ and CTC were evaluated in terms of general performance, microbial activity, diversity and abundance of antibiotic resistance genes (ARGs). The results showed that the consortia had great resistance to SDZ but were heavily affected by CTC. The presence of ARGs, particularly in Ca. Brocadia bacteria, played a significant role in the resistance mechanism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Marina Macedo-Vinas, Andrea Lucas
Summary: This study reports on the dynamics of microbial colonization of burn wounds in Uruguay. Similarities were found with reports elsewhere, but early colonization with yeasts and the absence of Streptococcus pyogenes were unique. Each burn center needs to monitor its microbial ecology to tailor their antimicrobial strategies effectively.
Article
Infectious Diseases
Alicia Sorgen, James Johnson, Kevin Lambirth, Sandra M. Clinton, Molly Redmond, Anthony Fodor, Cynthia Gibas
Summary: Antibiotic-resistant bacteria are more abundant in raw sewage and water before the biological aeration treatment stage in wastewater treatment plants. While some ARB can still be detected in treated wastewater, they are not enriched relative to upstream effluent-free water, indicating efficient removal during treatment.
Article
Environmental Sciences
Mengwei Zhang, Zhigao Zhou, Jinfeng Zhang, Yitian Yu, Liwei Sun, Tao Lu, Haifeng Qian
Summary: Difenoconazole can promote microalgae growth at environmental residual concentrations and aquatic microbial communities can self-regulate to cope with difenoconazole-induced stress. The dissemination of antibiotic resistance genes is enhanced in the short-term.
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2018)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
