Genomically humanized mice: technologies and promises

A BACwards glance at neurodegeneration: molecular insights into disease fromLRRK2,SNCAandMAPTBAC-transgenic mice

(2011) Sara J. Johnson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

(2011) C. Rathinam et al.   BLOOD

Generation and characterization of a humanized PPARδ mouse model

(2011) B Gross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Polycomb eviction as a new distant enhancer function

(2011) D. Vernimmen et al.   GENES & DEVELOPMENT

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

(2011) M. Hasegawa et al.   MOLECULAR PHARMACOLOGY

Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

(2011) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

In vivo genome editing restores haemostasis in a mouse model of haemophilia

(2011) Hojun Li et al.   NATURE

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

(2011) Shigeyuki Yamaguchi et al.   PLoS One

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells

(2011) P. Khandelia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

(2011) L. I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human

(2011) Patrick Schorderet et al.   PLoS Genetics

Refined human artificial chromosome vectors for gene therapy and animal transgenesis

(2010) Y Kazuki et al.   GENE THERAPY

Transgenic mice with a diverse human T cell antigen receptor repertoire

(2010) Liang-Ping Li et al.   NATURE MEDICINE

Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis

(2010) Shiaoching Gong et al.   Nature Protocols

Chromosome looping at the human  -globin locus is mediated via the major upstream regulatory element (HS -40)

(2009) D. Vernimmen et al.   BLOOD

A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice

(2009) Wolfgang Enard et al.   CELL

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

New approaches for modelling sporadic genetic disease in the mouse

(2009) E. M. C. Fisher et al.   Disease Models & Mechanisms

Cell to cell transfer of the chromatin-packaged human β-globin gene cluster

(2009) Nobutaka Suzuki et al.   NUCLEIC ACIDS RESEARCH

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

(2009) G. Yeretssian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-Specific Genes May Offer a Unique Window into Human Cell Signaling

(2009) P. D. Stahl et al.   Science Signaling

CYP1A1 and CYP1A2 expression: Comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

(2009) Shigeyuki Uno et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

The expanding role of mouse genetics for understanding human biology and disease

(2008) D. Nguyen et al.   Disease Models & Mechanisms

Species-Specific Transcription in Mice Carrying Human Chromosome 21

(2008) M. D. Wilson et al.   SCIENCE