Article
Energy & Fuels
Genmiao Guo, Tianyang Bai, Zhixia He, Wei Guan, Kang Yang, Chen Li, Shuohan Xu, Kang Lu
Summary: This work uses an improved cavitation model to study the impacts of needle lift and hole height on in-nozzle string cavitation. The results show that the driving mechanism behind string cavitation inception is the vortex evolution, and the patterns of string cavitation differ under various hole heights. Furthermore, reducing needle lift and increasing hole height are conducive to inducing string cavitation under certain flow velocity conditions.
Article
Pharmacology & Pharmacy
Zhizhi Wang, Dongxiao Song, Jian Wang, Liangcai Xiong, Tielin Shi, Chengsen Zhang, Linsen Di, Chunli Zhang, Yade Zhang, Haifei Li, Xin Liu, Jing Liu, Yong Zhang
Summary: Needle-free jet injection is a great alternative to conventional injection in reducing patients' fear of needles and needle-related injuries, as well as minimizing the risk of cross-contamination. This study utilized a realizable k-epsilon turbulence model to investigate the impact of different nozzle cone angles and lengths on injection performance. The simulation results were validated through experiments, showing that a smaller taper angle resulted in higher jet velocity and peak stagnation pressure within a specific range. Additionally, nozzle length had limited influence on peak stagnation pressure but had a noticeable effect on turbulence intensity. The findings provide insights for optimizing the nozzle structure of commercial needle-free jet injectors and achieving efficient drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Waiman Meinhold, Daniel Enrique Martinez, John Oshinski, Ai-Ping Hu, Jun Ueda
Summary: Recent advances in cellular therapeutics have showcased the potential of stem cell injections directly to the spinal cord, requiring either open surgery or MRI guided injection for accuracy. A newly developed MRI guided robotic needle positioning system aims to improve procedure time and accuracy, characterized by high precision and repeatability for needle guide positioning. This system demonstrates significant potential for enhancing the workflow of spinal injection procedures.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Thermodynamics
P. G. Aleiferis, N. Papadopoulos
Summary: The design of fuel injectors is crucial for high-efficiency engine combustion and low tailpipe emissions. Numerical predictions based on complete multiphase flow simulations of real injector geometry are highly desired to understand in-nozzle processes. Transient RANS modeling with compressibility, VOF method, and thermophysical fuel properties were used in this study to analyze the flow inside a Diesel injector nozzle with moving needle in various pressure and temperature conditions.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Materials Science, Ceramics
Zou Kai, Zhang Wenbin, Guan Sheng, Sun Haiyi, Peng Kailun, Zou Jiajie, Li Xuehong, Wang Cheng, Leng Yuxin, Liang Ruihong, Zhou Zhiyong
Summary: By utilizing piezoelectric high-temperature nozzle technology based on inverse-piezoelectric effect, researchers have achieved stable output of high-temperature tin droplet targets, making a breakthrough in the development of extreme ultra-violet lithography.
JOURNAL OF INORGANIC MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Roberto Bernasconi, Stefano Brovelli, Prisca Viviani, Marco Soldo, Domenico Giusti, Luca Magagnin
Summary: Drop-on-demand inkjet printing of highly viscous fluids is an emerging technology with great potential for industrial applications. The development of piezoelectric-driven printheads capable of jetting high-viscosity fluids is of interest, allowing for the deposition of ceramic suspensions and concentrated polymer solutions. In optimal conditions, solutions with viscosities exceeding 200 cP can be successfully jetted.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Mechanics
Louis-Vincent Bouthier, Francesco Delloro, Elie Hachem
Summary: In this study, an improved high fidelity modeling method was proposed to simulate gas and particle flow phenomena more accurately. The model was validated against existing data and demonstrated accurate predictions. A new nozzle geometry was also proposed using this high fidelity numerical framework.
Article
Biotechnology & Applied Microbiology
Zhiming Zhang, Kang Liu, Wenhui Li, Qiaoling Ji, Qiao Xu, Zilong Lai, Changjin Ke
Summary: This article studied four different spinning nozzles for fabricating nanofibers by high-speed centrifugal spinning method, optimizing the nozzle structures and observing the morphology and surface quality of nanofibers using scanning electron microscope. The results showed that conical-straight nozzle and curved-tube nozzle produced smoother nanofibers with smaller diameter compared to stepped and conical nozzles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Li Wang, Haojie Fu, Zhaofa Zhang, Jiajian Wang, Jiahua Feng, Bingheng Lu
Summary: This paper proposes and manufactures a new high-frequency and high-viscosity piezo-electric drop-on-demand (DOD) print head structure, with reliability confirmed through hydrodynamic and thermodynamic simulation analyses. The print head jetting performance is tested, showing a wide range of jetting viscosity and good jetting stability.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Sang-Won Woo, Yun Kyong Jo, Yeong-Eun Yoo, Sun Kyoung Kim
Summary: A plastic micro-channel device was designed for mass production of liposomes. Liposomes synthesized under different conditions were found to have diameters ranging from 230 to 260 nm.
Article
Multidisciplinary Sciences
Muhammad Salman, Hongyao Lin, Roypim Suntisukwattana, Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol
Summary: This study confirms the hematogenous transmission of African Swine Fever virus between pigs through needle-sharing.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Muhammad Salman, Hongyao Lin, Roypim Suntisukwattana, Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol
Summary: This study confirmed the hematogenous transmission of African Swine Fever virus (ASFV) between pigs through needle-sharing. The transmission rate was positively correlated with virus titer in blood circulation of seeder pigs. Sentinels injected with needles from high titer challenged seeder pigs displayed more severe and acute clinical disease.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Muhammad Salman, Hongyao Lin, Roypim Suntisukwattana, Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol
Summary: This study confirmed the hematogenous transmission of ASFV between pigs through needle-sharing. High levels of virus exposure may lead to more severe clinical disease.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Qiman Gao, Geoffroy Noel, Zovinar Der Khatchadourian, Doaa Taqi, Mohammad Abusamak, Anna Henley, Karim Menassa, Ana Velly, Elham Emami, Luc Mongeau, Faleh Tamimi
Summary: This study aimed to develop and evaluate the clinical safety and feasibility of an optimal NFLJI technique for dental anesthesia. Results showed that perpendicular NFLJIs induced more regurgitation and complications, while oblique NFLJIs had lower risks. Oblique NFLJIs could be a promising approach for dental infiltration anesthesia.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Denis Kislov, Daniel Ofer, Andrey Machnev, Hani Barhom, Vjaceslavs Bobrovs, Alexander Shalin, Pavel Ginzburg
Summary: The propulsion and acceleration of nanoparticles with light have both fundamental and applied significance. In this study, a new physical mechanism of laser-induced particle acceleration is explored based on abnormal optothermal expansion of mesoporous vaterite cargoes. The results show that vaterite nanoparticles can be accelerated towards a target tissue with a short femtosecond laser pulse, which has potential applications in drug delivery and monitoring.
