期刊
NATURE REVIEWS GENETICS
卷 11, 期 9, 页码 658-662出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2864
关键词
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资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P50HG003390] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH081203] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA011853] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P60DA011015, R01DA029258] Funding Source: NIH RePORTER
- NHGRI NIH HHS [P50 HG003390-03S1, P50-HG03390, P50 HG003390-05, P50 HG003390, P50 HG003390-05S1, P50 HG003390-04, P50 HG003390-03, P50 HG003390-04S1, P50 HG003390-05S2] Funding Source: Medline
- NIAAA NIH HHS [R01 AA011853-12, R01-AA11853, R01 AA011853-12S1, R01 AA011853, R01 AA011853-11] Funding Source: Medline
- NIDA NIH HHS [R01 DA029258-01, P60 DA011015-12, 5P60DA011015, R01 DA029258, R01-DA029258, P60 DA011015, P60 DA011015-11A1] Funding Source: Medline
- NIMH NIH HHS [R01-MH081203, R01 MH081203-01A2, R01 MH081203-02, R01 MH081203] Funding Source: Medline
A flood of comparative genomic data is resulting in the identification of human lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives, transgenic introduction of HLS sequences into these species has the greatest potential to produce 'humanized' phenotypes and also to illuminate the functions of these sequences. We argue that such transgenic apes would also be more likely than other species to experience harm from such research, which renders such studies ethically unacceptable in apes and justifies regulatory barriers between these species and other non-human primates for HLS transgenic research.
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