Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Mohamed Rela, Ashwin Rammohan
Summary: Liver transplantation is widely accepted as a treatment for end-stage liver disease, but the increasing demand for organs has led to a gap between supply and demand. The East tends to focus on living donor liver transplantation, while the West concentrates on optimizing the use of cadaveric livers. The differing approaches have resulted in varying levels of acceptance and utilization in different regions.
JOURNAL OF HEPATOLOGY
(2021)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Hillary J. Braun, Joshua D. Grab, Jennifer L. Dodge, Shareef M. Syed, Garrett R. Roll, Marisa P. Schwab, Iris H. Liu, Alexa C. Glencer, Chris E. Freise, John P. Roberts, Nancy L. Ascher
Summary: The study found that approximately 10% of patients who underwent living donor liver transplantation required retransplantation. Patients who received retransplantation had significantly lower survival rates compared to those who only underwent primary transplantation.
Article
Medicine, General & Internal
Seoung Hoon Kim, Jang Ho Park, Byoung Ho An
Summary: This study introduces how to perform LDLT with minimal manpower and evaluates the outcomes in adult patients. It shows that under the supervision of a single expert surgeon, a team of minimal manpower can successfully perform all the main surgical procedures without compromising the results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Surgery
Kwang-Woong Lee, YoungRok Choi, Suk Kyun Hong, Sola Lee, Su Young Hong, Sanggyun Suh, Eui Soo Han, Nam-Joon Yi, Kyung-Suk Suh
Summary: This study suggests that laparoscopic explant hepatectomy followed by robot-assisted engraftment is feasible in selected recipients only.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Tomoharu Yoshizumi, Shinji Itoh, Mototsugu Shimokawa, Shoichi Inokuchi, Noboru Harada, Kazuki Takeishi, Yohei Mano, Shohei Yoshiya, Takeshi Kurihara, Yoshihiro Nagao, Toru Ikegami, Yuji Soejima, Masaki Mori
Summary: The study demonstrates that simultaneous splenectomy after living donor liver transplantation can prevent small-for-size graft syndrome and improve graft survival rates. It is recommended to perform simultaneous splenectomy for patients with predicted small grafts, portal hypertension, or high portal pressure.
JOURNAL OF HEPATOLOGY
(2021)
Article
Surgery
Kyung-Suk Suh, Suk Kyun Hong, Sola Lee, Su Young Hong, Sanggyun Suh, Eui Soo Han, Seong-Mi Yang, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee
Summary: Minimally invasive living donor liver transplantation with pure laparoscopic techniques, including explant hepatectomy and graft implantation through a suprapubic incision, was performed successfully in a patient with liver cirrhosis and carcinoma. The procedure, conducted by an experienced surgical team, resulted in a smooth recovery and short hospital stay. Larger studies are needed to validate the safety and feasibility of this approach.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biotechnology & Applied Microbiology
Xiping Chen, Huan Xiao, Chunjiang Yang, Jingyu Chen, Yang Gao, Yi Tang, Xiaojuan Ji
Summary: This study investigated hemodynamic changes in infants undergoing living donor liver transplantation due to biliary atresia. Results showed a decrease in hepatic artery peak systolic velocity and resistivity index, and an increase in portal vein velocity and flow on the first day post-transplant. These changes remained stable within the first month after surgery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Arianna Barbetta, Mayada Aljehani, Michelle Kim, Christine Tien, Aaron Ahearn, Hannah Schilperoort, Linda Sher, Juliet Emamaullee
Summary: A systematic review comparing adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) found that LDLT is associated with improved patient survival, reduced waiting time, and lower MELD score, despite an increased risk of biliary complications. Hepatic artery thrombosis rates did not differ between the two types of transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Jeong-Moo Lee, Ahmed Shehta, Kwang-Woong Lee, Suk Kyun Hong, Jae-Hyung Cho, Nam-Joon Yi, Kyung-Suk Suh
Summary: Living-donor safety and cosmetic outcome are the main concerns. Pure laparoscopic living-donor hepatectomy (PLLDH) can provide a balance. Donors operated by PLLDH have better satisfaction scores compared to conventional open approach.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Virology
Shu-Hsien Lin, Kun-Ta Wu, Chih-Chi Wang, Ting-Ting Liu, Hock-Liew Eng, King-Wah Chiu
Summary: This study focused on the clinical significance of endoscopic biopsy-proven CMV colitis in patients following living donor liver transplantation. The study found that the incidence of CMV colitis after living donor liver transplantation was very low, and endoscopic biopsy with immunohistochemistry staining could improve the diagnostic accuracy.
Article
Nutrition & Dietetics
Kao-Ming Hsu, Pei-Ru Lin, Ping-Fang Chiu, Yao-Peng Hsieh
Summary: This study investigated the subsequent renal function change following incident infectious diseases in living-donor liver transplant recipients. The results showed that hospitalization with major infections or pneumonia increased the risk of eGFR decline and adverse renal outcomes in these patients.