Review
Medicine, General & Internal
Aline C. Ribeiro, Pamela S. A. S. Gerheim, Julio Maria Fonseca Chebli, Jorge Willian L. Nascimento, Priscila de Faria Pinto
Summary: This study examines the use of thiopurines for treating inflammatory bowel diseases (IBD) and the influence of genetic polymorphisms in the enzyme TPMT on therapeutic response and adverse effects. It suggests that patients with reduced TPMT activity are more prone to adverse reactions and proposes therapeutic monitoring of metabolite levels for optimizing treatment. Genotyping for TPMT is recommended to tailor dosing strategies and enhance treatment efficacy while minimizing myelosuppression. The study emphasizes the importance of considering genetic variations and metabolite levels in personalized thiopurine therapy for IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Zilin Deng, Yingying Zhao, Zhiyuan Ma, Minglin Zhang, Hu Wang, Zhiqiang Yi, Biguang Tuo, Taolang Li, Xuemei Liu
Summary: The incidence of gastrointestinal mucosal diseases is increasing, highlighting the need to identify new therapeutic targets. Ion channels/transporters play a crucial role in maintaining GI mucosal integrity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Plant Sciences
Palak Thakur, Rakesh Kumar, Neha Choudhary, Rohit Sharma, Ashun Chaudhary
Summary: This study explores the potential compounds and interaction mechanisms of Thymus linearis Benth. (TL) towards gastrointestinal complications and neurological diseases using network pharmacology and molecular docking. The research identifies valuable biologically active compounds in TL and emphasizes its potential in treating gastrointestinal and neurological diseases by regulating oxidative stress pathways. This study opens up possibilities for discovering antioxidant molecules for future drug development.
Article
Oncology
Doratha A. Byrd, Emily Vogtmann, Zeni Wu, Yongli Han, Yunhu Wan, Joe-Nat Clegg-Lamptey, Joel Yarney, Beatrice Wiafe-Addai, Seth Wiafe, Baffour Awuah, Daniel Ansong, Kofi Nyarko, Autumn G. Hullings, Xing Hua, Thomas Ahearn, James J. Goedert, Jianxin Shi, Rob Knight, Jonine D. Figueroa, Louise A. Brinton, Montserrat Garcia-Closas, Rashmi Sinha
Summary: The gut microbiota may influence breast cancer development by regulating hormonal, metabolic and immunologic pathways. Associations between fecal bacteria and both breast cancer and nonmalignant breast disease were studied in Ghana, with findings indicating strong and similar correlations with both conditions. This suggests potential microbial mechanisms of breast disease.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Leander Corrie, Monica Gulati, Ankit Awasthi, Sukriti Vishwas, Jaskiran Kaur, Rubiya Khursheed, Omji Porwal, Aftab Alam, Shaik Rahana Parveen, Hardeep Singh, Dinesh Kumar Chellappan, Gaurav Gupta, Popat Kumbhar, John Disouza, Vandana Patravale, Jon Adams, Kamal Dua, Sachin Kumar Singh
Summary: Polysaccharides have been extensively studied and used as therapeutic agents and drug carriers. They possess properties such as porosity, stability, and swellability, making them ideal for various pharmaceutical formulations. Recent reports have shown the potential of polysaccharides as therapeutic agents for inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Stefania Cheli, Marta Fusi, Annalisa De Silvestri, Igor Bonini, Emilio Clementi, Dario Cattaneo, Cristina Montrasio, Sara Baldelli
Summary: The study indicates that CYP3A5 gene polymorphisms may significantly impact the metabolism of linezolid, increasing the risk of underexposure in patients, while P-glycoprotein gene polymorphisms seem to have no role.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Plant Sciences
Wei Guan, Wang Qi
Summary: Ginseng is a highly valuable Chinese medicine with a wide range of pharmacological activities. Ginsenoside Rh2, one of its main active compounds, has shown potential in the treatment of nonmalignant and malignant diseases. However, the underlying mechanisms of Rh2 in these diseases are still unclear. This review provides a comprehensive summary of the roles and potential mechanisms of Rh2 in different diseases, as well as the combination therapy with other medications. The bioavailability of oral administration of Rh2 remains a challenge for future research.
Review
Immunology
Maria Maslinska, Joanna Dmowska-Chalaba, Michal Jakubaszek
Summary: The role of IgG4 in IgG4-RD and other autoimmune diseases has attracted attention. IgG4, as a unique subclass of immunoglobulins, is generally considered non-inflammatory and tolerance inducing, but in IgG4-RD, it may play a pathogenic role in fibrogenesis and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Malgorzata Kozak, Andrzej Pawlik
Summary: Periodontal disease is a complex and infectious illness caused by a disruption of bacterial homeostasis. It leads to an inflammatory response and damage to tooth-supporting tissues. The causes and pathogenesis of periodontal disease are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Teresa Di Chio, Christiane Sokollik, Diego G. Peroni, Lara Hart, Giacomo Simonetti, Franziska Righini-Grunder, Osvaldo Borrelli
Summary: Nutritional management in pediatric gastrointestinal diseases is increasingly popular, with disease-specific diets as conventional treatments. Nutritional support is crucial for maintaining growth and improving outcomes, but dietary modifications may have negative consequences. Expert supervision is advised to prevent misconceptions and potential adverse effects from diet modification.
Review
Respiratory System
Lucia Ferreiro, Ana Casal, Maria Elena Toubes, Juan Suarez-Antelo, Antonio Golpe, Romina Abelleira-Paris, Vanessa Riveiro, Jose Manuel Alvarez-Dobano, Luis Valdes
Summary: Although pleural effusion is common in clinical practice, it can be challenging to determine its cause, with up to 20% of cases remaining undiagnosed. Nonmalignant gastrointestinal diseases can be a source of pleural effusion, which can be confirmed through patient history, physical examination, and abdominal ultrasonography. Accurate interpretation of pleural fluid from thoracentesis is crucial in this process. The diagnosis and appropriate treatment of this condition depend on the specialist's evaluation of the pleural fluid appearance and relevant tests.
Review
Nutrition & Dietetics
Tim Vanuytsel, Jan Tack, Ricard Farre
Summary: Intestinal permeability plays a crucial role in various gastrointestinal and non-gastrointestinal disorders, with evidence showing its importance in conditions like celiac disease and inflammatory bowel disease. While ex vivo techniques remain the gold standard for assessing epithelial barrier function, in vivo techniques, despite their limitations, are widely used in research and clinical practice.
FRONTIERS IN NUTRITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Schmidkonz, Torsten Kuwert, Armin Atzinger, Michael Cordes, Georg Schett, Andreas Ramming, Theresa Goetz
Summary: This article provides a comprehensive review of the use of fibroblast activation protein (FAP) imaging in nonmalignant diseases. Although there have been many studies on the use of FAPI imaging in cancer, evidence for its use in nonmalignant diseases is lacking.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Medicine, General & Internal
Mattia Paratore, Matteo Garcovich, Maria Elena Ainora, Livio Enrico Del Vecchio, Giuseppe Cuccia, Laura Riccardi, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Ultrasound imaging is the preferred method for investigating abdominal symptoms and can diagnose various pathological conditions in the gastrointestinal tract. Ultrasound elastography, a recent technological advancement, allows the evaluation of tissue characteristics like neoplastic transformation or inflammation. It has been extensively used in studying liver diseases and other clinical settings, including gastrointestinal diseases. This paper summarizes the evidence of different ultrasound elastography modalities in non-liver gastrointestinal diseases.
Review
Cell Biology
Jing Cao, Anni Zhou, Zhuoyang Zhou, Hui Liu, Shaohui Jia
Summary: This study reviewed the structure, functions, and localization of GPLD1 in chronic diseases, as well as exercise-mediated regulation of GPLD1, providing a theoretical support for developing GPLD1 as a new therapeutic target for chronic diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)