Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility

Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis

(2011) Gwendolyn W. Louis et al.   ENDOCRINOLOGY

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

(2011) Janette H. Quennell et al.   ENDOCRINOLOGY

Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain

(2011) Shel-Hwa Yeo et al.   ENDOCRINOLOGY

Kisspeptin Regulates Gonadotroph and Somatotroph Function in Nonhuman Primate Pituitary via Common and Distinct Signaling Mechanisms

(2011) Raúl M. Luque et al.   ENDOCRINOLOGY

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

(2011) Christian Mayer et al.   NATURE NEUROSCIENCE

Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice

(2011) Andreas Stengel et al.   NEUROREPORT

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

(2010) Víctor M. Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neurokinin B and the hypothalamic regulation of reproduction

(2010) Naomi E. Rance et al.   BRAIN RESEARCH

Kisspeptins: Bridging energy homeostasis and reproduction

(2010) Juan M. Castellano et al.   BRAIN RESEARCH

Twice-Weekly Administration of Kisspeptin-54 for 8 Weeks Stimulates Release of Reproductive Hormones in Women With Hypothalamic Amenorrhea

(2010) C N Jayasena et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Neurobiology of Preovulatory and Estradiol-Induced Gonadotropin-Releasing Hormone Surges

(2010) Catherine A. Christian et al.   ENDOCRINE REVIEWS

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

(2010) Ginah L. Kim et al.   ENDOCRINOLOGY

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

(2010) Kathryn Backholer et al.   ENDOCRINOLOGY

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

(2010) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep

(2010) Heather J. Billings et al.   ENDOCRINOLOGY

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons

(2010) E. Hrabovszky et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Decrease in HypothalamicKiss1andKiss1rExpression: A Potential Mechanism for Fasting-induced Suppression of the HPG Axis in the Adult Male Rhesus Monkey (Macaca mulatta)

(2010) F. Wahab et al.   HORMONE AND METABOLIC RESEARCH

TAC3/TACR3Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

(2010) Elena Gianetti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TAC3andTACR3Defects Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans

(2010) Jacques Young et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

(2010) Jose Donato et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat

(2010) Cadence True et al.   JOURNAL OF NEUROENDOCRINOLOGY

Kisspeptin Signaling Is Required for Peripheral But Not Central Stimulation of Gonadotropin-Releasing Hormone Neurons by NMDA

(2010) X. d'Anglemont de Tassigny et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

(2010) L.-Y. Fu et al.   JOURNAL OF NEUROSCIENCE

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

(2010) Y. Wakabayashi et al.   JOURNAL OF NEUROSCIENCE

Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty

(2010) Jenny Clarkson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

Timing and completion of puberty in female mice depend on estrogen receptor  -signaling in kisspeptin neurons

(2010) C. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy balance and puberty onset: emerging role of central mTOR signaling

(2010) Juan Roa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Kisspeptin Signaling in the Brain

(2009) Amy E. Oakley et al.   ENDOCRINE REVIEWS

Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe

(2009) Kathryn Backholer et al.   ENDOCRINOLOGY

Kisspeptin Neurons in the Ovine Arcuate Nucleus and Preoptic Area Are Involved in the Preovulatory Luteinizing Hormone Surge

(2009) J. T. Smith et al.   ENDOCRINOLOGY

Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status

(2009) Eneida C. Villanueva et al.   ENDOCRINOLOGY

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

The Excitatory Peptide Kisspeptin Restores the Luteinizing Hormone Surge and Modulates Amino Acid Neurotransmission in the Medial Preoptic Area of Middle-Aged Rats

(2009) Genevieve Neal-Perry et al.   ENDOCRINOLOGY

Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist

(2009) R. Pineda et al.   ENDOCRINOLOGY

Distribution and Postnatal Development ofGpr54Gene Expression in Mouse Brain and Gonadotropin-Releasing Hormone Neurons

(2009) Allan E. Herbison et al.   ENDOCRINOLOGY

Kisspeptin Increases γ-Aminobutyric Acidergic and Glutamatergic Transmission Directly to Gonadotropin-Releasing Hormone Neurons in an Estradiol-Dependent Manner

(2009) Justyna Pielecka-Fortuna et al.   ENDOCRINOLOGY

Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function

(2009) M. Tena-Sempere   INTERNATIONAL JOURNAL OF ANDROLOGY

Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain

(2009) J. Clarkson et al.   JOURNAL OF NEUROENDOCRINOLOGY

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

(2009) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

(2009) A. K. Roseweir et al.   JOURNAL OF NEUROSCIENCE

Mouse fertility is not dependent on the CREB coactivator Crtc1

(2009) Lionel Breuillaud et al.   NATURE MEDICINE

Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to estradiol positive feedback in middle-aged rats

(2009) Matthew A. Lederman et al.   NEUROPHARMACOLOGY

Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat

(2009) S.J. Krajewski et al.   NEUROSCIENCE

Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat

(2009) Sarah Forbes et al.   NEUROSCIENCE LETTERS

Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction

(2009) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetic cell sensors: a key to metabolic homeostasis

(2009) Mourad Naïmi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states

(2008) J. Roa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic pathways linking energy balance and reproduction

(2008) Jennifer W. Hill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR

(2008) Stephen C Woods et al.   Annual Review of Nutrition

Follicle-Stimulating Hormone Responses to Kisspeptin in the Female Rat at the Preovulatory Period: Modulation by Estrogen and Progesterone Receptors

(2008) J. Roa et al.   ENDOCRINOLOGY

Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals

(2008) Xavier d'Anglemont de Tassigny et al.   ENDOCRINOLOGY

Opposite Roles of Estrogen Receptor (ER)-α and ERβ in the Modulation of Luteinizing Hormone Responses to Kisspeptin in the Female Rat: Implications for the Generation of the Preovulatory Surge

(2008) J. Roa et al.   ENDOCRINOLOGY

Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy

(2008) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Alterations in Hypothalamic KiSS-1 System in Experimental Diabetes: Early Changes and Functional Consequences

(2008) J. M. Castellano et al.   ENDOCRINOLOGY

Insulin-Like Growth Factor-I Activates KiSS-1 Gene Expression in the Brain of the Prepubertal Female Rat

(2008) Jill K. Hiney et al.   ENDOCRINOLOGY

Fasting Reduces KiSS-1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS-1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats

(2008) T. Kalamatianos et al.   JOURNAL OF NEUROENDOCRINOLOGY

Down-Regulation of HypothalamicKisspeptinand its Receptor,Kiss1r, mRNA Expression is Associated with Stress-Induced Suppression of Luteinising Hormone Secretion in the Female Rat

(2008) J. S. Kinsey-Jones et al.   JOURNAL OF NEUROENDOCRINOLOGY

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

(2008) C. Zhang et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin-GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

(2008) J. Clarkson et al.   JOURNAL OF NEUROSCIENCE

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS

The Creb1 coactivator Crtc1 is required for energy balance and fertility

(2008) Judith Y Altarejos et al.   NATURE MEDICINE

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

(2008) Naomi E. Rance   PEPTIDES

Kisspeptins and the control of gonadotropin secretion in male and female rodents

(2008) J. Roa et al.   PEPTIDES

Transgenic mouse models to study Gpr54/kisspeptin physiology

(2008) W.H. Colledge   PEPTIDES

From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

(2008) Michelle L. Gottsch et al.   PEPTIDES

The neuroanatomy of the kisspeptin system in the mammalian brain

(2008) Jens D. Mikkelsen et al.   PEPTIDES

KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications

(2008) J.M. Castellano et al.   PEPTIDES

Ghrelin as a pleotrophic modulator of gonadal function and reproduction

(2008) Manuel Tena-Sempere   Nature clinical practice. Endocrinology & metabolism

Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

(2007) Justyna Pielecka-Fortuna et al.   ENDOCRINOLOGY

Gonadotropin-Releasing Hormone Neuron Requirements for Puberty, Ovulation, and Fertility

(2007) Allan E. Herbison et al.   ENDOCRINOLOGY

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

(2007) Juan Roa et al.   FRONTIERS IN NEUROENDOCRINOLOGY