Article
Biochemistry & Molecular Biology
Fiona Jenkinson, Kang Wei Tan, Barbara Schopf, Miguel M. Santos, Philip Zegerman
Summary: In eukaryotes, cyclin-dependent kinase (CDK) inhibits helicase loading factors to ensure the exact duplication of the genome. CDK activates origin firing by phosphorylating Sld2 and Sld3, forming a transient intermediate called the pre-initiation complex (pre-IC). In yeast, the CDK phosphorylations of Sld3 and Sld2 are rapidly turned over by the phosphatases PP2A and PP4 during S phase. This dephosphorylation is important for genome-wide origin firing, pre-IC formation, and maintaining Sld3 dephosphorylation in G1 phase. PP2ARts1 specifically targets Sld3 and its dephosphorylation is critical for replication and cell viability.
Article
Cell Biology
Kaiyuan Wu, Allen Seylani, Jing Wu, Xufeng Wu, Christopher K. E. Bleck, Michael N. Sack
Summary: The functional interaction of BLOC1S1 with the kinesin binding complex and the actin cytoskeleton are essential for lysosomal tubulation, which plays a key role in lysosome recycling through autophagic lysosome reformation (ALR).
Article
Behavioral Sciences
Yulong Ma, Erlong Niu, Fei Xie, Min Liu, Miao Sun, Or Ye Peng, Hang Guo
Summary: The study showed that electroacupuncture could restore the expression levels of estrogen receptors and the neuroprotective effects of estrogen replacement therapy in 10-week ovariectomized rats. However, it was not effective in 20-week ovariectomized rats.
BRAIN AND BEHAVIOR
(2021)
Review
Immunology
Xiaojun Zhong, Yulin Sun, Yajun Lu, Lei Xu
Summary: Estrogen, especially 17 beta-estradiol, has been shown in clinical trials to mitigate cerebral damage caused by ischemic stroke. Its mechanism of action involves modulating immune cell responses, suggesting its potential as a novel therapeutic strategy. This review summarizes the impact of sex on ischemic stroke progression, the immunomodulatory role of estrogen, and the clinical value of estrogen replacement therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Jin Wang, Min Liu, Wugang Hou, Min Hou, Lixia Zhang, Miao Sun, Siyuan Liu, Huikai Yang, Hang Guo, Xiaoying Zhang, Fei Xie, Yanhong Liu, Yulong Ma
Summary: This study demonstrates that estrogen alleviates cerebral ischemic injury by upregulating Ndrg2 through ER beta, which activates astrocytes, indicating that Ndrg2 is a critical mediator of estrogen-induced neuroprotection against cerebral ischemic injury.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Surgery
Jonathan J. Hue, Kavin Sugumar, Mohamedraed Elshami, Luke D. Rothermel, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
Summary: The timing of multiagent neoadjuvant chemotherapy initiation is not associated with survival in patients with pancreatic adenocarcinoma. Patient optimization may improve tolerance of multiagent chemotherapy.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Microbiology
Maria Eugenia Cortina, R. Clayton Bishop, Brittany A. DeVasure, Isabelle Coppens, Isabelle Derre
Summary: This study identified an inclusion membrane protein, IncS, as a critical factor for the development of Chlamydia. The findings suggest that IncS could be a potential target for therapeutic intervention of sexually transmitted infections caused by bacterial origin.
Article
Multidisciplinary Sciences
Moaz Ahmad, Hwei Ling Ong, Hassan Saadi, Ga-Yeon Son, Zahra Shokatian, Lara E. Terry, Mohamed Trebak, David Yule, Indu Ambudkar
Summary: This study reveals that immobilization of STIM2 clusters within ER-PM junctions, as a first response to ER-Ca2+ store depletion, is facilitated by the juxtaposition of IP3R and marks a checkpoint for initiation of Ca2+ entry.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Shalmali Patkar, Dafe Uwanogho, Michel Modo, Rothwelle J. Tate, Robin Plevin, Hilary V. O. Carswell
Summary: The knockdown of Dax-1 increases the production of 17 beta-estradiol in neural stem cells, leading to improved functional recovery after stroke. Targeting the biosynthesis of 17 beta-estradiol in stem cells may be a promising therapeutic strategy for enhancing the efficacy of stem cell-based therapies for stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Sophie L. Fayad, Guillaume Ourties, Benjamin Le Gac, Baptiste Jouffre, Sylvain Lamoine, Antoine Fruquiere, Sophie Laffray, Laila Gasmi, Bruno Cauli, Christophe Mallet, Emmanuel Bourinet, Thomas Bessaih, Regis C. Lambert, Nathalie Leresche, Gary L. Westbrook
Summary: Cav3.2 channels expressed in GABAergic neurons in the anterior pretectum contribute to high-frequency bursting activity and play a role in neuropathic pain.
Article
Biochemistry & Molecular Biology
Elisa De Marchi, Lorenzo Botta, Bruno Mattia Bizzarri, Raffaele Saladino
Summary: In this study, quinol derivatives were synthesized by blue LED-driven photo-oxygenation, which can be used as effective pro-drugs in steroid replacement therapy with high yield and selectivity.
Review
Cell Biology
Kyrylo Fotesko, Bo Schneider Vohra Thomsen, Miriam Kolko, Rupali Vohra
Summary: Estrogen deficiency may lead to the loss of retinal ganglion cells and visual impairment, potentially causing glaucoma. Estrogen replacement therapy may be a beneficial treatment, but further research is needed to confirm its role in glaucoma prevention.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Engineering, Biomedical
Wenxiu He, Zhiwen Zhang, Xianyi Sha
Summary: This review outlines the emerging approaches of nanoparticles in the effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. It reveals the potentials and challenges of nanoparticles in treating ischemic stroke, and proposes new thoughts and perspectives for the design of feasible nanoparticles for effective treatment.
Article
Engineering, Aerospace
Yuen Liu, Qing Xie, Yuxuan Chen, Remy Mevel, Zhuyin Ren
Summary: A critical decay time (CDT) model is introduced to predict the critical energy for direct detonation initiation in gaseous mixtures. The model is based on a global initiation criterion that ensures the decaying shock speed remains within a specific range below the Chapman-Jouguet (CJ) speed for a critical decay time. The CDT model provides accurate estimations of critical initiation energy for various fuel-oxidizer mixtures.
JOURNAL OF PROPULSION AND POWER
(2023)
Article
Biochemistry & Molecular Biology
Azizul Haque, Arabinda Das, Supriti Samantaray, Denise Matzelle, Mollie Capone, Gerald Wallace, Aarti N. Husarik, Saied Taheri, Russel J. Reiter, Abhay Varma, Swapan K. Ray, Naren L. Banik
Summary: This study demonstrated that PRM treatment for 7 days can reduce post-SCI lesion volume, attenuate neuronal cell death, inflammation, and axonal damage, and modify the balance of apoptotic proteins. PRM also enhances angiogenesis and microvascular growth, with neuroprotection potentially mediated through estrogen receptors. The inhibition of glial activation, decreased inflammation and cell death, and increased angiogenesis by PRM lead to improved functional outcome in the rat model as evaluated by the BBB locomotor scale.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)