Review
Biochemistry & Molecular Biology
Shushan Ge, Jihui Li, Yu Yu, Zhengguo Chen, Yi Yang, Liqing Zhu, Shibiao Sang, Shengming Deng
Summary: Breast cancer is the most frequently occurring cancer globally, with HER2 overexpression affecting prognosis. Molecular imaging technologies can non-invasively, in real time, and quantitatively reflect the expression status of HER2 in tumors, providing a new approach for treatment selection and monitoring treatment response for patients.
Article
Materials Science, Paper & Wood
Juergen Reitbauer, Franz Harrer, Rene Eckhart, Wolfgang Bauer
Summary: This study utilized optical-based focus variation measurement method to investigate the surface characteristics of tissue paper, developed a comprehensive characterization procedure, and identified differences in surface roughness and structural features among different tissue grades. By using the focus variation method, researchers were able to further analyze the 3D surface information and conduct surface roughness evaluation.
Review
Radiology, Nuclear Medicine & Medical Imaging
Zeyu Zhang, Kunshan He, Chongwei Chi, Zhenhua Hu, Jie Tian
Summary: Intraoperative fluorescence molecular imaging (FMI) has rapidly developed in China and has been successfully used in precise resection and other applications in cancer surgeries. The combination of FMI with other modalities for surgical navigation has also been discussed. Designing new cancer-specific fluorescent tracers is expected to enhance surgical outcomes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
James Ryan Loftus, Savita Puri, Steven P. Meyers
Summary: Neurodegenerative diseases such as dementia are becoming increasingly prevalent worldwide, but current clinical diagnosis methods have limited accuracy. Multiparametric magnetic resonance imaging and molecular imaging offer the potential for more specific and sensitive diagnosis of neurodegenerative diseases. This review provides an overview of the epidemiology, clinical presentation, and pathology of common and uncommon neurodegenerative diseases, as well as detailed descriptions of imaging features using various techniques. The review also explores the use of molecular imaging with radiotracers for diagnosis and discusses future research directions, including the use of combined positron emission tomography/magnetic resonance imaging scanners.
INSIGHTS INTO IMAGING
(2023)
Review
Biotechnology & Applied Microbiology
Sadia Naz, Pi Liu, Umar Farooq, Hongwu Ma
Summary: Regulation of amino acid's biosynthetic pathway is crucial for cellular functions. The discovery of feedback resistant enzyme variants to enhance amino acid production is a key objective in industrial biotechnology. Structural analysis and mutagenesis techniques have been used to deregulate feedback inhibition and understand the effects of mutations on enzyme function.
MICROBIAL CELL FACTORIES
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nhung H. A. Nguyen, Priscila Falagan-Lotsch
Summary: Nanotechnology has great potential in the biomedical field, but the limited understanding of nano-bio interactions has hindered their use and commercialization. Understanding these interactions is crucial in nanotoxicology and nanomedicine to develop safe nanomaterials and improve the efficacy of nanomedicines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Zi Yi Xu, Xiao Hu Wang, Sha Li Huang, Jing Rong Chen, Hong Qun Luo, Nian Bing Li
Summary: Traditionally, fluorescent molecules with red-region fluorescence require large conjugating segments and fused rings, which increase their size and molecular weight, thus reducing their membrane permeability and biocompatibility. However, a novel low-molecular-weight compound called CouMal, derived from the traditional coumarin core, unexpectedly possesses red-region fluorescence and exhibits great cytomembrane penetrability and reduced cytotoxicity. It has potential applications in intracellular and in vivo imaging. Furthermore, a reaction-based sensing system called TCMal-Et3N has been developed based on the synthetic procedure of CouMal, which can precisely detect silver ion (Ag+) with a limit of detection as low as 60.9 nM. This sensing system shows excellent selectivity and short reaction time, and can accurately quantify Ag+ and silver nanoparticles (AgNPs) in real-world representative samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Mangmang Sang, Yibo Huang, Lu Wang, Nawsherwan, Lei Chen, Gang Li, Yan Wang, Xiu Yu, Cuilian Dai, Jinrong Zheng
Summary: Developing activatable fluorescent probes with high fluorescence enhancement factor (F/F-0) is urgent to improve signal-to-noise ratio (S/N). In this study, an AND logic gate was developed as a super-enhancer for designing activatable probes with large F/F-0 and S/N ratio. The probe utilized lipid-droplets (LDs) as background input and target analyte as variable input to achieve high F/F-0 ratio. This probe showed improved selectivity and S/N ratio compared to a commercial probe and successfully delineated atherosclerotic plaques in mouse models.
Review
Nanoscience & Nanotechnology
Yue Gao, Chengyan Chu, Anna Jablonska, Jeff W. M. Bulte, Piotr Walczak, Miroslaw Janowski
Summary: Extracellular vesicles (EVs) have garnered attention as potential therapeutic agents, especially in the field of central nervous system diseases. Successful clinical studies require more information on the biodistribution and tracking of EVs in vivo. Advanced imaging techniques play a crucial role in facilitating the clinical translation of EV-based therapeutics.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Immunology
Swati Shah, Mitchell L. Turner, Xueyi Chen, Beau M. Ances, Dima A. Hammoud, Elizabeth W. Tucker
Summary: Diagnosis, monitoring, and assessing response to therapy of CNS infections is challenging. Molecular imaging techniques can complement anatomic imaging for studying the development and treatment response of CNS infections. Pathogen-specific radiotracers can accurately diagnose CNS infections and have the potential to cross the blood-brain barrier.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Cell & Tissue Engineering
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi, Jafar Ai
Summary: Multiple sclerosis (MS) is a chronic central nervous system disease with limited treatment options, leading researchers to explore new therapies such as mesenchymal stromal cell (MSC) transplantation. Allogeneic MSCs are suggested as a potential novel solution for MS therapy as an alternative to autologous MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Physics, Nuclear
Susan Gardner, Samuel D. McDermott, Brian Yanny
Summary: The increasing precision astrometric observations from the Gaia space telescope and other surveys are providing detailed insights into the structure and dynamics of the Milky Way, including its interactions with satellite galaxies, stellar streams, and dark matter. Research on dwarf galaxies within the Galaxy's halo and predictions of cold dark matter paradigm at small mass scales are also significant in understanding the evolution of the Milky Way.
PROGRESS IN PARTICLE AND NUCLEAR PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Zuoneng Wang, Qingyang Zhang, Carsten Mim
Summary: Cryo electron microscopy has become the most important method in structural biology, with single particle analysis and electron tomography being the main approaches, while sub-tomogram averaging has matured. Current resolution ranges from 2 to 5 angstrom, showing promise for future developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Liesbeth Everix, Shankari Nair, Cathryn H. S. Driver, Ingeborg Goethals, Mike M. Sathekge, Thomas Ebenhan, Charlot Vandevoorde, Julie Bolcaen
Summary: This review discusses the current use of DDR kinases for the treatment of GB and explores the potential role of radiopharmaceuticals in personalized GB therapy. Four potential new therapeutic GB radiopharmaceuticals are suggested.