Article
Biochemical Research Methods
Sarah Battat, David A. Weitz, George M. Whitesides
Summary: This article discusses how the field of microfluidics can increase its impact by improving technologies and enabling new functionalities, focusing on applications in diagnostics, food safety, and materials production. The article identifies technical challenges, including simplifying sample preparation procedures, finding materials for microfluidic device production, and automating the operation of microfluidic devices.
Review
Genetics & Heredity
Khairiah Razali, Noratikah Othman, Mohd Hamzah Mohd Nasir, Abd Almonem Doolaanea, Jaya Kumar, Wisam Nabeel Ibrahim, Norlinah Mohamed Ibrahim, Wael M. Y. Mohamed
Summary: Parkinson's disease is the second most prevalent neurodegenerative disorder in the elderly, with unclear etiology and no disease-modifying medicines available. The use of MPTP is fundamental in most animal models of PD, and zebrafish is emerging as a promising model for studying PD due to its unique properties.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Renjie Wang, Kairong Xiong, Zhimin Wang, Di Wu, Bai Hu, Jinghan Ruan, Chaoyang Sun, Ding Ma, Li Li, Shujie Liao
Summary: Immunotherapy has shown significant effectiveness in various types of cancer, but the majority of patients do not benefit from it. Evaluating tumor heterogeneity and immune status before treatment is crucial for identifying patients who are more likely to respond to immunotherapy. Demographic characteristics, immune status, and specific biomarkers all play a role in the response to immunotherapy. An integrated immunodiagnostic model utilizing artificial intelligence could provide valuable information for predicting treatment response. We introduce the concept of immunodiagnosis as the blueprint for this model, discuss the features it should include, and outline the strategy for constructing it. Furthermore, we explore the potential incorporation of this immunodiagnosis model in clinical practice in order to improve the prognosis of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Maryam Salehi
Summary: Global water shortages due to various factors have led to water utilities and consumers adopting different practices to cope, which may pose risks to water quality. It is important to conduct consistent monitoring and implement mitigation strategies to reduce potential risks.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dianwen Ng, Hao Du, Melissa Min-Szu Yao, Russell Oliver Kosik, Wing P. Chan, Mengling Feng
Summary: Advances in AI technology in medical imaging hold potential to enhance the efficiency of radiologists' work, but there are still challenges in the replacement of human radiologists with AI.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Genetics & Heredity
Vipin Singh, Shweta Pandey, Anshu Bhardwaj
Summary: The Reference Human Genome is important for mapping genetic variations, but it has limitations. Population-specific references have been developed to account for ethnic and geographical diversity. Advances in genome sequencing and long range sequencers have allowed the development of a more comprehensive standard reference, the Human Pangenome Project, which captures maximal genetic variation and provides deep annotation for accurate clinical significance estimation. However, challenges include variant discovery tools, exhaustive annotation, and ethical considerations.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Joshua J. Goings, Alec White, Joonho Lee, Christofer S. Tautermann, Matthias Degroote, Craig Gidney, Toru Shiozaki, Ryan Babbush, Nicholas C. Rubin
Summary: An accurate assessment of the potential computational advantages of quantum computers in chemical simulation is crucial for their deployment. This study explores the resources required for assessing the electronic structure of cytochrome P450 enzymes using quantum and classical computations, defining a boundary for classical-quantum advantage. The results show that simulation of large-scale CYP models has the potential to be a quantum advantage problem, emphasizing the interplay between classical computations and quantum algorithms in chemical simulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Health Care Sciences & Services
Ioannis Stouras, Theodore G. Papaioannou, Konstantinos Tsioufis, Aristides G. Eliopoulos, Despina Sanoudou
Summary: Despite the availability of numerous drugs for cardiovascular disease, challenges remain in ensuring their safe and effective use. Dietary elements and genetic variation can impact the absorption, distribution, and action of drugs, highlighting the importance of personalized cardiovascular healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Business
Qingsong Hou, Zhihao Chen, Min Teng
Summary: This study finds that strengthening the patent examination system encourages substantive innovation and improves the overall quality of innovation output for firms. The impact of the strengthened patent examination system on firms' innovation strategies is regulated by technology intensity and ownership type.
JOURNAL OF BUSINESS RESEARCH
(2022)
Review
Cell Biology
Jasin Taelman, Monica Diaz, Jordi Guiu
Summary: The study of human intestinal biology in healthy and diseased conditions has always been challenging, but the development of three-dimensional organoid cultures has transformed this. Intestinal organoids can recapitulate the identity, heterogeneity, and behavior of the original tissue, and have been instrumental in modeling human intestinal development, disease, and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Development Studies
Bernd Ermes, Tudor Mocanu, Anja Willke, Michaela Schuerig
Summary: This article discusses the development of the mobility sector in a specific area in Germany. With the phase-out of lignite-based power generation, the Rhenish coal-mining area will face structural changes and challenges. The article focuses on the field of action Mobility in the Rhenish coal-mining area, investigating the current state and modeling future scenarios to reduce CO2 emissions and achieve climate targets.
JOURNAL OF ENVIRONMENTAL PLANNING AND MANAGEMENT
(2023)
Article
Psychology, Applied
Peikai Li, Toon W. Taris, Maria C. W. Peeters
Summary: The study investigates how appraisals influence stressor-outcome relationships in the workplace. It finds that employees have different profiles of job demands appraisal, with some being positivists, negativists, or indifferent workers. Positivists have higher well-being and are more likely to change their appraisal profiles over time. The study highlights the importance for organizations to provide resources and support to promote positive appraisals.
JOURNAL OF OCCUPATIONAL AND ORGANIZATIONAL PSYCHOLOGY
(2022)
Article
Health Care Sciences & Services
Alfredo Cesario, Marika D'Oria, Irene Simone, Stefano Patarnello, Vincenzo Valentini, Giovanni Scambia
Summary: Personalized medicine utilizes digital and technological solutions to drive innovation and generate new knowledge, while the open innovation paradigm effectively manages transformation in healthcare organizations. This article examines the transition from personalized medicine to personalized digital medicine in a large research hospital, discussing methods, challenges, and results.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medical Laboratory Technology
Alison Hellmann, Ashley Emmons, Matthew Stewart Prime, Ketan Paranjape, Denise L. Heaney
Summary: AI is becoming an indispensable tool in various healthcare settings, helping clinicians and patients to make informed decisions. This article discusses the role of AI in healthcare, from providing guidance to clinicians to empowering patients to take control of their own health. While the exact role of AI in healthcare is still being defined, it is clear that those who do not adopt AI may be left behind.
CLINICS IN LABORATORY MEDICINE
(2023)
