Article
Oncology
Julio A. Aguirre-Ghiso
Summary: Understanding cancer dormancy has reshaped the paradigm of metastasis, explaining long remission intervals followed by relapse. While there is consensus on the potential impact of better understanding dormancy, controversy exists on applying this biology to clinical trials. Active clinical trials are resolving these controversies, providing opportunities to target cancer dormancy in reality.
Review
Pharmacology & Pharmacy
Gary L. Griffiths, Crystal Vasquez, Freddy Escorcia, Jeff Clanton, Liza Lindenberg, Esther Mena, Peter L. Choyke
Summary: Molecular Imaging is in an exciting period of its history, with many new agents under development and some already reaching the clinic. This article provides an overview of the processes involved in discovering and validating a new molecular imaging agent, using a low molecular weight disease-specific targeted PET agent as an example. It also discusses the different phases of studies and the post-approval aspects of novel molecular imaging agents.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Biology
Amit K. Dey, Reema Banarjee, Mozhgan Boroumand, Delaney V. Rutherford, Quinn Strassheim, Thedoe Nyunt, Bradley Olinger, Nathan Basisty
Summary: Cellular senescence is an irreversible growth arrest with significant phenotypic changes, including the senescence-associated secretory phenotype (SASP). The accumulation of senescent cells contributes to aging and various pathologies, such as chronic inflammation, type 2 diabetes, cancer, and neurodegeneration. Targeted removal of senescent cells has shown promising results in promoting health and longevity in preclinical models, suggesting it as a potential therapeutic approach for age-related diseases. However, the translation of senescence-targeting drugs into clinical practice requires a better understanding of the complex and dynamic biology of senescent cell populations, their molecular profiles, and the underlying mechanisms of senescence cell emergence and maintenance. Proteomic technologies, especially mass spectrometry-based proteomics, have the potential to address these needs. This review discusses the current state of translational senescence research and how proteomic approaches have advanced our understanding of senescence biology. It also presents a roadmap for the clinical translation of senotherapeutic approaches through the development and application of emerging proteomic technologies. These technologies are crucial for examining the cellular composition and dynamics of senescent cells, and ultimately, the development of senotype-specific biomarkers and senotherapeutics (senolytics and senomorphics). This review aims to highlight emerging areas and applications of proteomics that will contribute to exploring new senescent cell biology and the future translation of senotherapeutics.
Review
Microbiology
Zhenrun J. Zhang, Christopher J. Lehmann, Cody G. Cole, Eric G. Pamer
Summary: This study reviews recent research on the influence of the gut microbiota on human health and disease susceptibility and resistance. It discusses the association between gut microbiota and certain human diseases and highlights translational advances in using gut microbiota to treat diseases. The opportunities and challenges in translating microbiome research from and to the bedside are also discussed.
ANNUAL REVIEW OF MICROBIOLOGY
(2022)
Review
Oncology
Wei-Wei Chen, Timothy Shun Man Chu, LiangLiang Xu, Cai-Ning Zhao, Wai-Sang Poon, Gilberto Ka-Kit Leung, Feng-Ming (Spring) Kong
Summary: This article discusses immune-related biomarkers for cancer metastasis to the brain and the potential use of these markers in predicting disease progression and treatment outcomes. The authors hope to inspire further research and establish practical guidelines for developing and validating immune-related biomarkers to provide personalized treatment and improve outcomes for patients with metastatic brain cancers.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Cell Biology
Jan Philipp Bewersdorf, Omar Abdel-Wahab
Summary: This review discusses the development of promising new molecular targeted approaches for AML, as well as progress in immune targeting of AML through various antibodies and cellular therapies. Despite FDA approval of new drugs for AML, it remains a major area of unmet medical need among hematologic malignancies.
GENES & DEVELOPMENT
(2022)
Review
Cell Biology
Yujie Zhang, Yuxin Zhang, Lin Peng, Li Zhang
Summary: Esophageal cancer is a malignant tumor with poor prognosis in China. Surgery is the main treatment method, especially for early and mid-stage patients, to achieve radical cure. However, the high recurrence and metastasis risk of esophageal cancer remains a challenge after surgery.
Review
Pharmacology & Pharmacy
Yifei Meng, Jingdong Cao, Yidan Li, Saili Duan, Zongjiang Zhou, Jinghe Li, Diabate Ousmane, Chunlin Ou, Junpu Wang
Summary: Tumor metastasis is a major factor contributing to poor prognosis in patients with tumors. Research on the mechanism of metastasis is crucial to address this problem. Ferroptosis, a newly recognized mode of cell death, has been found to affect tumor metastasis and inhibit tumor progression. Circular RNA (circRNA), a type of non-coding RNA, has been shown to be associated with ferroptosis and tumor development. However, the specific mechanisms of how circRNAs influence ferroptosis and their role in tumor metastasis remain unknown. This review systematically discusses the role of circRNAs in regulating tumor ferroptosis and their mechanism of action through sponging miRNAs in various tumors, providing insights for future targeted therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Miriam B. Garcia, Keri L. Schadler, Joya Chandra, Steven K. Clinton, Kerry S. Courneya, Zobeida Cruz-Monserrate, Carrie R. Daniel, Andrew J. Dannenberg, Wendy Demark-Wahnefried, Mark W. Dewhirst, Carol J. Fabian, Stephen D. Hursting, Melinda L. Irwin, Neil M. Iyengar, Jennifer L. McQuade, Kathryn H. Schmitz, Karen Basen-Engquist
Summary: Advances in energy balance and cancer research often occur independently in animal models and clinical studies. However, there is great potential in integrating these two approaches through parallel studies, where animal models inform clinical research and vice versa. The conference Translating Energy Balance from Bench to Communities brought together researchers to share insights and successful examples of parallel studies, aiming to advance our understanding of the role of energy balance in cancer development, outcomes, and survivorship.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Cell Biology
Ewa Nowak, Ilona Bednarek
Summary: Epithelial to mesenchymal transition (EMT) is a critical process in tumor progression that influences metastasis, characterized by loss of cell adhesion and polarity, and enhanced cell motility. Epigenetic regulatory mechanisms play a significant role in the gene expression involved in EMT, impacting the development and progression of cancer.
Review
Biochemistry & Molecular Biology
Zhilin Qu, Dasen Yan, Zhen Song
Summary: This article reviews the progress and challenges in modeling intracellular calcium cycling in the cardiac system. The calcium release channels in cardiac myocytes form a network that gives rise to various dynamic processes. Modeling the intracellular calcium cycling dynamics in the cardiac system is challenging due to its complexity.
Review
Oncology
Sanjeev Kumar, Allegra Freelander, Elgene Lim
Summary: The nuclear receptor family of transcription factors plays a vital role in breast cancer development, progression, and treatment, with crosstalk between nuclear receptor pathways and growth factor signaling demonstrated in all major subtypes of breast cancer. The majority of breast cancers are driven by estrogen receptor alpha (ER), and anti-estrogenic therapies have led to significant improvements in patient outcomes. Recent findings into modulating other nuclear receptors such as progesterone (PR) and androgen receptors (AR) have led to clinical trials in major breast cancer subtypes, supporting the potential targeting of these receptors for improved patient outcomes.
Review
Obstetrics & Gynecology
M. A. Riegler, M. H. Stensen, O. Witczak, J. M. Andersen, S. A. Hicks, H. L. Hammer, E. Delbarre, P. Halvorsen, A. Yazidi, N. Holst, T. B. Haugen
Summary: In recent years, there has been an exponential increase in data generated in the field of ART, with a diverse range from videos to tabular data. Artificial intelligence (AI) is progressively being used in medical practice, especially in fertility clinics, to potentially improve success rates. AI models are being developed to address the lack of objectivity in critical procedures, such as embryo and sperm assessments, but there are still challenges to overcome in order to fully utilize AI in ART.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Hend Baghoum, Hend Alahmed, Mahmood Hachim, Abiola Senok, Nour Jalaleddine, Saba Al Heialy
Summary: Microgravity is a potential strategy for developing cancer therapies, particularly in lung cancer. This study demonstrates the influence of microgravity on cellular processes and the migratory capacity of lung cancer cells. It identifies differentially expressed genes associated with the prognosis of lung cancer under simulated microgravity and highlights the potential of these genes as tumor suppressor biomarkers. The study also reveals the ability of microgravity to revert the epithelial-to-mesenchymal transition phenotype and suggests new therapeutic opportunities for lung cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Iqra Mobeen, Mirna Azalea Romero, Ishmuratova Margarita Yulaevna, Rukset Attar, Saima Jabeen, Sundas Fayyaz
Summary: This article summarizes the regulation of different oncogenic pathways in carcinogenesis and metastasis by genistein, as well as its modulation of non-coding RNAs. It also includes a discussion on clinical trials related to genistein for cancer prevention/inhibition. The article points out potential hints of a pro-metastatic role of genistein, highlighting the need for rational testing in a broader context.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Oncology
Gonzalo Recondo, Laura Mezquita, Francesco Facchinetti, David Planchard, Anas Gazzah, Ludovic Bigot, Ahsan Z. Rizvi, Rosa L. Frias, Jean Paul Thiery, Jean-Yves Scoazec, Tony Sourisseau, Karen Howarth, Olivier Deas, Dariia Samofalova, Justine Galissant, Pauline Tesson, Floriane Braye, Charles Naltet, Pernelle Lavaud, Linda Mahjoubi, Aurelie Abou Lovergne, Gilles Vassal, Rastilav Bahleda, Antoine Hollebecque, Claudio Nicotra, Maud Ngo-Camus, Stefan Michiels, Ludovic Lacroix, Catherine Richon, Nathalie Auger, Thierry De Baere, Lambros Tselikas, Eric Solary, Eric Angevin, Alexander M. Eggermont, Fabrice Andre, Christophe Massard, Ken A. Olaussen, Jean-Charles Soria, Benjamin Besse, Luc Friboulet
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Maria L. Lotsberg, Katarzyna Wnuk-Lipinska, Stephane Terry, Tuan Zea Tan, Ning Lu, Laura Trachsel-Moncho, Gro V. Rosland, Muntequa I. Siraji, Monica Hellesoy, Austin Rayford, Kirstine Jacobsen, Henrik J. Ditzel, Olav K. Vintermyr, Trever G. Bivona, John Minna, Rolf A. Brekken, Bruce Baguley, David Micklem, Lars A. Akslen, Gro Gausdal, Anne Simonsen, Jean Paul Thiery, Salem Chouaib, James B. Lorens, Agnete Svendsen Tenfjord Engelsen
JOURNAL OF THORACIC ONCOLOGY
(2020)
Correction
Medicine, General & Internal
Arvind Iyer, Krishan Gupta, Shreya Sharma, Kishore Hari, Yi Fang Lee, Neevan Ramalingam, Yoon Sim Yap, Jay West, Ali Asgar Bhagat, Balaram Vishnu Subramani, Burhanuddin Sabuwala, Tuan Zea Tan, Jean Paul Thiery, Mohit Kumar Jolly, Naveen Ramalingam, Debarka Sengupta
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Malina Xiao, Meriem Hasmim, Audrey Lequeux, Kris Van Moer, Tuan Zea Tan, Christine Gilles, Brett G. Hollier, Jean Paul Thiery, Guy Berchem, Bassam Janji, Muhammad Zaeem Noman
Summary: This study highlights the importance of CMTM6 and CMTM7 in regulating PD-L1 expression in aggressive breast cancer cells. Activating EMT process in breast cancer cells upregulates CMTM6, which is essential for cell surface expression of PD-L1. Dual targeting CMTM6 and CMTM7 can decrease PD-L1 surface expression, suggesting potential therapeutic benefits in highly aggressive breast cancer patients.
Article
Oncology
Sissel E. Dyrstad, Maria L. Lotsberg, Tuan Zea Tan, Ina K. N. Pettersen, Silje Hjellbrekke, Deusdedit Tusubira, Agnete S. T. Engelsen, Thomas Daubon, Arnaud Mourier, Jean Paul Thiery, Olav Dahl, James B. Lorens, Karl Johan Tronstad, Gro V. Rosland
Summary: In patients with non-small cell lung cancer (NSCLC), targeting aerobic glycolysis can enhance the therapeutic effects of EGFR tyrosine kinase inhibitors (EGFR TKIs) and ionizing radiation, potentially preventing the development of resistance. This study suggests that inhibiting glycolysis could redirect metabolism towards pyruvate oxidation and reduce lactate production, leading to increased mitochondrial activity and deacidification of the extracellular microenvironment, ultimately enhancing the efficacy of EGFR TKIs and ionizing radiation in NSCLC.
Review
Oncology
Amin Talebi, Jean Paul Thiery, Mohammad Amin Kerachian
Summary: Chimeric transcripts are important for diagnosis and prognosis, but their identification from FFPE tissues is limited due to the reduced quality and quantity of RNA. Strategies need to be developed to overcome these limitations and maximize the potential of FFPE tissues as a source for fusion transcript identification.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemical Research Methods
Vlada S. Rozova, Ayad G. Anwer, Anna E. Guller, Hamidreza Aboulkheyr Es, Zahra Khabir, Anastasiya Sokolova, Maxim U. Gavrilov, Ewa M. Goldys, Majid Ebrahimi Warkiani, Jean Paul Thiery, Andrei Zvyagin
Summary: The study used machine learning and image analysis to examine how individual breast cancer cells respond to substrates of varying stiffness, revealing significant changes in cell morphology and molecular expression. The results suggest that the stiffest microenvironment can induce MET, providing new insights into the process of metastasis.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Maha Elazezy, Sandra Schwentesius, Luisa Stegat, Harriet Wikman, Stefan Werner, Wael Y. Mansour, Antonio Virgilio Failla, Sven Peine, Volkmar Mueller, Jean Paul Thiery, Majid Ebrahimi Warkiani, Klaus Pantel, Simon A. Joosse
Summary: This study reveals that keratin 16 is a critical protein promoting cancer metastasis, associated with epithelial-mesenchymal transition (EMT) and positive regulation of cell motility, with its expression in circulating tumor cells correlating with shorter relapse-free survival in patients. Therefore, keratin 16 could serve as a prognostic marker to identify cancer patients at higher risk of metastasis.
Review
Oncology
Xuecong Wang, Jean Paul Thiery
Summary: Epithelial cell plasticity is a key feature of cancer progression, achieved mainly through epithelial-mesenchymal transition, giving cancer cells unique properties of tumor dissemination and therapy resistance. Different degrees of plasticity are attained through transcriptional regulation and feedback loops. Study on the plasticity in carcinoma may lead to the discovery of new therapeutic strategies against cancer.
Article
Oncology
Ching-Hung Lin, Ruby Yun-Ju Huang, Tzu-Pin Lu, Kuan-Ting Kuo, Ko-Yun Lo, Ching-Hsuan Chen, I-Chun Chen, Yen-Shen Lu, Eric Y. Chuang, Jean Paul Thiery, Chiun-Sheng Huang, Ann-Lii Cheng
Summary: The incidence of breast cancer among women under 50 years old in East Asia has been rapidly increasing, with unique genetic alterations identified in these tumors such as copy number loss in the APOA1/C3/A4/A5 gene cluster. This genetic change may have immunomodulatory effects on the tumor microenvironment and play various roles in the tumor biology of East Asian patients.
Article
Multidisciplinary Sciences
Darwesh Mohideen Kaderbatcha Aladin, Yeh Shiu Chu, Shuo Shen, Robert Charles Robinson, Sylvie Dufour, Virgile Viasnoff, Nicolas Borghi, Jean Paul Thiery
Summary: This study reveals that different EC repeats in cadherins' extracellular regions can modulate epithelial sheet integrity, cell-cell separation forces, and cell cortical tension, which further affect epithelial tensile strength, ductility, and collective migration. Interestingly, dissipative processes rather than static adhesion energy play a dominant role in cell-cell separation forces. This framework provides insights into how epithelial phenotypes emerge from cell mechanical properties dependent on EC outside-in signaling.
Editorial Material
Oncology
Valerie S. LeBleu, Jean Paul Thiery
Summary: Epithelial-to-mesenchymal transition (EMT) is an epithelial plasticity program associated with embryonic development and organogenesis, which plays an important role in metastatic dissemination and secondary tumor formation.
Review
Medicine, Research & Experimental
Alexey Rzhevskiy, Alina Kapitannikova, Polina Malinina, Arthur Volovetsky, Hamidreza Aboulkheyr Es, Arutha Kulasinghe, Jean Paul Thiery, Anna Maslennikova, Andrei V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Immunotherapy, particularly immune checkpoint inhibitor therapy, has revolutionized cancer treatment in recent years. However, slow uptake in clinical oncology is attributed to high treatment costs, associated toxicities, and variability in patient response. Personalized approaches based on predictive biomarkers have emerged as new tools to enhance the effectiveness of immunotherapy.
Article
Cell Biology
Hamidreza Aboulkheyr Es, Bahareh Bigdeli, Sareh Zhand, Amir R. Aref, Jean P. Thiery, Majid E. Warkiani
Summary: This study revealed that mesenchymal stem cells (MSCs) may regulate the immune-suppression capacity of the tumor microenvironment (TME) by stimulating the expression of PD-L1 in breast cancer cells. The findings suggest that MSCs-derived CCL5 could act as a stimulator for PD-L1 in breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Maria L. Lotsberg, Austin Rayford, Jean Paul Thiery, Giuliana Belleggia, Stacey D'Mello Peters, James B. Lorens, Salem Chouaib, Stephane Terry, Agnete S. T. Engelsen
CANCER DRUG RESISTANCE
(2020)