Denosumab in patients with cancer—a surgical strike against the osteoclast

Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts

(2015) Toru Akiyama et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bisphosphonates in oncology

(2011) Robert E. Coleman et al.   BONE

Phase II Trial of Saracatinib (AZD0530), an Oral SRC-inhibitor for the Treatment of Patients with Hormone Receptor-negative Metastatic Breast Cancer

(2011) Ayca Gucalp et al.   Clinical Breast Cancer

Overall Survival Benefit of Radium-223 Chloride (Alpharadin™) in the Treatment of Patients with Symptomatic Bone Metastases in Castration-resistant Prostate Cancer (CRPC): a Phase III Randomized Trial (ALSYMPCA)

(2011) C. Parker et al.   EUROPEAN JOURNAL OF CANCER

Randomized, Double-Blind Study of Denosumab Versus Zoledronic Acid in the Treatment of Bone Metastases in Patients With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma

(2011) David H. Henry et al.   JOURNAL OF CLINICAL ONCOLOGY

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

(2011) Karim Fizazi et al.   LANCET

Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial

(2011) Michael Gnant et al.   LANCET ONCOLOGY

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Breast-Cancer Adjuvant Therapy with Zoledronic Acid

(2011) Robert E. Coleman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metastasis and bone loss: Advancing treatment and prevention

(2010) Robert E. Coleman et al.   CANCER TREATMENT REVIEWS

RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells

(2010) Toru Akiyama et al.   CLINICAL & EXPERIMENTAL METASTASIS

Understanding and Optimizing Bone Health in Breast Cancer

(2010) Theresa A. Guise et al.   CURRENT MEDICAL RESEARCH AND OPINION

Zoledronic acid

(2010) Robert Coleman et al.   Expert Opinion On Drug Safety

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

Examining the Metastatic Niche: Targeting the Microenvironment

(2010) Theresa Guise   SEMINARS IN ONCOLOGY

An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma

(2009) Ravi Vij et al.   AMERICAN JOURNAL OF HEMATOLOGY

Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer

(2009) E. Y. Yu et al.   CLINICAL CANCER RESEARCH

Randomized Phase II Trial of Denosumab in Patients With Bone Metastases From Prostate Cancer, Breast Cancer, or Other Neoplasms After Intravenous Bisphosphonates

(2009) Karim Fizazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of Coronary Artery Disease by Computed Tomography Angiography in Patients Treated for Childhood Hodgkin's Lymphoma

(2009) Serhan Küpeli et al.   JOURNAL OF CLINICAL ONCOLOGY

Editorial Board

(2009)   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

The critical role of the bone microenvironment in cancer metastases

(2009) Sandra Casimiro et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer

(2009) Matthew R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Denosumab on Bone Mineral Density and Bone Turnover in Postmenopausal Women

(2008) Henry G. Bone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Randomized Trial of Denosumab in Patients Receiving Adjuvant Aromatase Inhibitors for Nonmetastatic Breast Cancer

(2008) Georgiana K. Ellis et al.   JOURNAL OF CLINICAL ONCOLOGY