Challenges translating breast cancer gene signatures into the clinic

Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data?

(2012) Takayuki Iwamoto et al.   Genome Medicine

The Evolving War on Cancer

(2011) Daniel A. Haber et al.   CELL

Genetic Interactions in Cancer Progression and Treatment

(2011) Alan Ashworth et al.   CELL

Do predictive signatures really predict response to cancer chemotherapy? 

(2011) Piet Borst et al.   CELL CYCLE

Microarray-Based Class Discovery for Molecular Classification of Breast Cancer: Analysis of Interobserver Agreement

(2011) Alan Mackay et al.   JNCI-Journal of the National Cancer Institute

Deflating the Genomic Bubble

(2011) J. P. Evans et al.   SCIENCE

Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology

(2010) Keith A. Baggerly et al.   Annals of Applied Statistics

molecular biology (pre-clinical)

(2010)   ANNALS OF ONCOLOGY

Prognostic Value of a Combined ER, PgR, Ki67, HER2 Immunohistochemical (IHC4) Score and Comparison with the GHI Recurrence Score – Results from TransATAC.:

(2010) J. Cuzick et al.   CANCER RESEARCH

Central Review of ER, PgR and HER2 in BIG 1-98 Evaluating Letrozole vs. Letrozole Followed by Tamoxifen vs. Tamoxifen Followed by Letrozole as Adjuvant Endocrine Therapy for Postmenopausal Women with Hormone Receptor-Positive Breast Cancer.

(2010) G. Viale et al.   CANCER RESEARCH

Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer

(2010) A. Tabchy et al.   CLINICAL CANCER RESEARCH

A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

(2010) M. Graeser et al.   CLINICAL CANCER RESEARCH

Current and emerging biomarkers in breast cancer: prognosis and prediction

(2010) Marion T Weigel et al.   ENDOCRINE-RELATED CANCER

Breast cancer molecular profiling with single sample predictors: a retrospective analysis

(2010) Britta Weigelt et al.   LANCET ONCOLOGY

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

(2010) M. C. Villarroel et al.   MOLECULAR CANCER THERAPEUTICS

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

(2010)   NATURE BIOTECHNOLOGY

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

Breast cancer assessment tools and optimizing adjuvant therapy

(2010) Catherine Oakman et al.   Nature Reviews Clinical Oncology

Targeted therapy in non-small-cell lung cancer—is it becoming a reality?

(2010) Filip Janku et al.   Nature Reviews Clinical Oncology

Analysis of the genome to personalize therapy for melanoma

(2010) M A Davies et al.   ONCOGENE

Molecular Profiling: Moving Away from Tumor Philately

(2010) J. S. Reis-Filho et al.   Science Translational Medicine

Using Functional Genetics to Understand Breast Cancer Biology

(2010) A. Ashworth et al.   Cold Spring Harbor Perspectives in Biology

Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response

(2009) Jorma J. de Ronde et al.   BREAST CANCER RESEARCH AND TREATMENT

Clinical evaluation of chemotherapy response predictors developed from breast cancer cell lines

(2009) Cornelia Liedtke et al.   BREAST CANCER RESEARCH AND TREATMENT

Predictive signatures for chemotherapy sensitivity in breast cancer: Are they ready for use in the clinic?

(2009) Hervé Bonnefoi et al.   EUROPEAN JOURNAL OF CANCER

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type

(2009) Britta Weigelt et al.   JOURNAL OF PATHOLOGY

Calibration and discriminatory accuracy of prognosis calculation for breast cancer with the online Adjuvant! program: a hospital-based retrospective cohort study

(2009) Stella Mook et al.   LANCET ONCOLOGY

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Molecular predictors of response to trastuzumab and lapatinib in breast cancer

(2009) Francisco J. Esteva et al.   Nature Reviews Clinical Oncology

Gene-Expression Signatures in Breast Cancer

(2009) Christos Sotiriou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes

(2008) C. Desmedt et al.   CLINICAL CANCER RESEARCH

Estrogen- and Progesterone-Receptor Status in ECOG 2197: Comparison of Immunohistochemistry by Local and Central Laboratories and Quantitative Reverse Transcription Polymerase Chain Reaction by Central Laboratory

(2008) Sunil S. Badve et al.   JOURNAL OF CLINICAL ONCOLOGY