期刊
NATURE PHOTONICS
卷 7, 期 3, 页码 247-254出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHOTON.2012.337
关键词
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资金
- Army Research Office Young Investigator Award
- Presidential Early Career Award for Scientists and Engineers (PECASE)
- NSF
- Office of Naval Research Young Investigator Award
- National Institutes of Health (NIH) [DP2OD006427]
- Carnot Institutes Network
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0954482] Funding Source: National Science Foundation
The direct observation of nanoscale objects is a challenging task for optical microscopy because the scattering from an individual nanoparticle is typically weak at optical wavelengths. Electron microscopy therefore remains one of the gold standard visualization methods for nanoparticles, despite its high cost, limited throughput and restricted field-of-view. Here, we describe a high-throughput, on-chip detection scheme that uses biocompatible wetting films to self-assemble aspheric liquid nanolenses around individual nanoparticles to enhance the contrast between the scattered and background light. We model the effect of the nanolens as a spatial phase mask centred on the particle and show that the holographic diffraction pattern of this effective phase mask allows detection of sub-100 nm particles across a large field-of-view of >20 mm(2). As a proof-of-concept demonstration, we report on-chip detection of individual polystyrene nanoparticles, adenoviruses and influenza A (H1N1) viral particles.
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