Article
Multidisciplinary Sciences
Dan Song, Lisha Kuang, Lin Yang, Lei Wang, Hao Li, Xiu Li, Zhimin Zhu, Chaowei Shi, Haining Zhu, Weimin Gong
Summary: The study reveals the mechanism of stress granule (SGs) formation, demonstrating the interaction of G3BP1 protein with Caprin-1 and USP10 to facilitate or suppress SG formation. The N- and C-terminal domains of Caprin-1 play opposing roles in regulating SG formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Karli Mockenhaupt, Katarzyna M. Tyc, Adam McQuiston, Alexandra K. Gonsiewski, Masoumeh Zarei-Kheirabadi, Avani Hariprashad, Debolina D. Biswas, Angela S. Gupta, Amy L. Olex, Sandeep K. Singh, Michael R. Waters, Jeff L. Dupree, Mikhail G. Dozmorov, Tomasz Kordula
Summary: The transcription factor YY1 is expressed in astrocytes and plays a critical role in regulating gene expression and maturation of cerebellar astrocytes. It is also necessary for maintaining the mature phenotype of astrocytes in the adult cerebellum.
Review
Immunology
Joana M. Pereira, Shuying Xu, John M. Leong, Sandra Sousa
Summary: PLY is a pore-forming toxin produced by Streptococcus pneumoniae, playing a dual role as a key bacterial virulence factor and a trigger for host immune modulation. It promotes bacterial colonization and survival, while also triggering innate and adaptive host immune responses against bacterial infection. PLY displays Yin and Yang properties during infection, promoting disease by membrane perforation and activating inflammatory pathways, while also mitigating damage by triggering host cell repair and initiating anti-inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Zhiying Shao, Wendong Yang, Xiannan Meng, Minle Li, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Summary: YY1 is highly expressed in colorectal cancer and is widely recognized as an oncogenic factor throughout the course of the disease. Future studies should take the influence of therapeutic regimens into consideration.
Article
Cardiac & Cardiovascular Systems
Shu-Yi Wei, Yu-Tsung Shih, Hsin-Yi Wu, Wei-Li Wang, Pei Ling Lee, Chih- Lee, Chia-Yu Lin, Yu-Ju Chen, Shu Chien, Jeng-Jiann Chiu
Summary: This study reveals that disturbed flow induces increased expression of phosphorylated YY1 (S118) in endothelial cells, promoting atherosclerosis. This phenomenon is mediated by the direct interaction of CK2 alpha with YY1, and the direct binding of phosphorylated YY1 (S118) with ZKSCAN4.
CIRCULATION RESEARCH
(2021)
Review
Immunology
Ece Canan Sayitoglu, Robert Arthur Freeborn, Maria Grazia Roncarolo
Summary: Tr1 cells, induced in the periphery under tolerogenic conditions, promote peripheral tolerance through secretion of IL-10 and TGF-beta as well as exerting cytotoxicity. Clinical trials have shown promising results for Tr1 cell therapy in terms of efficacy and safety.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Laura Santambrogio, Alessandra Franco
Summary: This article summarizes the recognition of the MHC-self immunopeptidome by regulatory and conventional T cells under steady state and inflammatory conditions. It discusses how changes in the MHC-ligandome can affect the balance between pro-inflammatory and regulatory T cell expansion.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Pierre-Emmanuel Girault-Sotias, Romain Gerbier, Adrien Flahault, Nadia de Mota, Catherine Llorens-Cortes
Summary: Apelin plays a significant role in controlling body fluid homeostasis through central and renal actions, inhibiting vasopressin release and regulating renal microcirculation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Nipal Deka, Coleman Alleman, Douglas L. Medlin, Ryan B. Sills
Summary: Dislocation patterns play a crucial role in the mechanical properties of metals. Contrary to previous thinking, we demonstrate that both energy minimization and stochasticity are responsible for the emergence and nature of dislocation patterns.
MATERIALS RESEARCH LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Lorena Elena Melit, Cristina Oana Marginean, Maria Oana Sasaran
Summary: Pediatric obesity is a global issue and its relationship with gut microbiota is not fully understood. Multiple factors, such as maternal diet and health, delivery method, and feeding patterns, shape the infant gut microbiome. Firmicutes and Bacteroidetes have been identified as important players in obesity risk, but there are inconsistencies in studies, especially in pediatric populations.
Review
Immunology
Samantha M. Borys, Arup K. Bag, Laurent Brossay, Dennis O. Adeegbe
Summary: The current literature primarily focuses on NK and CD8(+) T cells, but there is evidence that KLRG1 plays a crucial role in suppressive Tregs. The role of KLRG1 on Tregs is still not fully understood and requires further investigation. In the development of cancer and autoimmunity, the role of the KLRG1(+) Treg subset also needs to be explored.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Rao Fu, Jie Li, Huatao Yu, Yang Zhang, Zhihong Xu, Cathie Martin
Summary: The success of Western scientific medicine can be seen in the improvements in life expectancy and reduction in infectious diseases, but challenges remain with drug-resistant infections and new diseases. Traditional Chinese Medicine offers personalized treatments based on centuries of practice, complementing Western medicine for comprehensive care. Combination of WSM and TCM can benefit patients in terms of speed and efficacy of recovery or disease management.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Oncology
Radomir M. Slominski, Tadeusz Sarna, Przemyslaw M. Plonka, Chander Raman, Anna A. Brozyna, Andrzej T. Slominski
Summary: Melanin plays a vital role in protecting the skin from harmful UV radiation, but its presence may also contribute to the malignant transformation of melanocytes. The biosynthesis of melanin is regulated by sun exposure and hormonal factors, influencing melanoma development, progression, and treatment in diverse ways.
FRONTIERS IN ONCOLOGY
(2022)
Review
Anatomy & Morphology
Matthew E. Larkum, Lucy S. Petro, Robert N. S. Sachdev, Lars Muckli
FRONTIERS IN NEUROANATOMY
(2018)
Article
Neurosciences
Mazahir T. Hasan, Ferdinand Althammer, Miriam Silva da Gouveia, Stephanie Goyon, Marina Eliava, Arthur Lefevre, Damien Kerspern, Jonas Schimmer, Androniki Raftogianni, Jerome Wahis, H. Sophie Knobloch-Bollmann, Yan Tang, Xinying Liu, Apar Jain, Virginie Chavant, Yannick Goumon, Jan-Marek Weislogel, Rene Prime Hurlemann, Sabine C. Herpertz, Claudia Pitzer, Pascal Darbon, Godwin K. Dogbevia, Ilaria Bertocchi, Matthew E. Larkum, Rolf Sprengel, Hilmar Bading, Alexandre Charlet, Valery Grinevich
Article
Biochemistry & Molecular Biology
Johanna Sigl-Gloeckner, Eduard Maier, Naoya Takahashi, Robert Sachdev, Matthew Larkum, Michael Brecht
Article
Neurosciences
Sina E. Dominiak, Mostafa A. Nashaat, Keisuke Sehara, Hatem Oraby, Matthew E. Larkum, Robert N. S. Sachdev
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Mototaka Suzuki, Matthew E. Larkum
Article
Multidisciplinary Sciences
Albert Gidon, Timothy Adam Zolnik, Pawel Fidzinski, Felix Bolduan, Athanasia Papoutsi, Panayiota Poirazi, Martin Holtkamp, Imre Vida, Matthew Evan Larkum
Article
Neurosciences
Naoya Takahashi, Christian Ebner, Johanna Sigl-Gloeckner, Sara Moberg, Svenja Nierwetberg, Matthew E. Larkum
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Keisuke Sehara, Paul Zimmer-Harwood, Matthew E. Larkum, Robert N. S. Sachdev
Summary: Computer vision techniques, particularly deep-learning approaches, have been increasingly used for offline tracking behavior and estimating animal poses without markers. This research developed a method using DeepLabCut for real-time estimation of mouse movements, training a DNN offline with high-speed video data and transferring the network to work in real-time with the same mouse.By tracking whisker movements and converting them into output signals within behavioral time scales, this approach can be used to trigger outputs based on individual whisker movements or distances between adjacent whiskers, complementing optogenetic approaches for manipulating movement and neural activity relationships directly.
Article
Biochemistry & Molecular Biology
Naoya Takahashi, Sara Moberg, Timothy A. Zolnik, Julien Catanese, Robert N. S. Sachdev, Matthew E. Larkum, Dieter Jaeger
Summary: The frontal cortical circuits, basal ganglia, and ventromedial thalamic nucleus play critical roles in action selection and initiation, with recent studies identifying new key nodes and signal transmission mechanisms in mice and primates.
Article
Biochemistry & Molecular Biology
Albert Gidon, Jaan Aru, Matthew Evan Larkum
Summary: This article discusses the rapid progress in neuroscience in understanding the brain, as well as a thought experiment on consciousness involving recording and replaying neural activity to reconstruct conscious experience. The possible outcomes of this experiment reveal hidden costs and pitfalls in understanding consciousness, challenging the traditional wisdom linking action potentials and consciousness.
Article
Multidisciplinary Sciences
Jaerin Sohn, Mototaka Suzuki, Mohammed Youssef, Sayuri Hatada, Matthew E. Larkum, Yasuo Kawaguchi, Yoshiyuki Kubota
Summary: This study reveals that two presynaptic neural circuits regulate the spine dynamics of pyramidal cell dendrites during learning. New spines formed with corticocortical neurons are eliminated after skill acquisition, while persistent spines with axons from thalamic neurons enlarge. This suggests a division of labor in the neural circuits of the motor cortex during skill learning.
Article
Multidisciplinary Sciences
Guy Doron, Jiyun N. Shin, Naoya Takahashi, Moritz Druke, Christina Bocklisch, Salina Skenderi, Lisa de Mont, Maria Toumazou, Julia Ledderose, Michael Brecht, Richard Naud, Matthew E. Larkum
Article
Neurosciences
Keisuke Sehara, Viktor Bahr, Ben Mitchinson, Martin J. Pearson, Matthew E. Larkum, Robert N. S. Sachdev
Article
Neurosciences
Jaan Aru, Mototaka Suzuki, Renate Rutiku, Matthew E. Larkum, Talis Bachmann
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2019)
Article
Neurosciences
Christian Ebner, Julia Ledderose, Timothy A. Zolnik, Sina E. Dominiak, Paul Turko, Athanasia Papoutsi, Panayiota Poirazi, Britta J. Eickholt, Lmre Vida, Matthew E. Larkum, Robert N. S. Sachdev
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2019)
