Article
Cell & Tissue Engineering
Ping Wang, Yan Cui, Jing Wang, Donghua Liu, Yue Tian, Kai Liu, Xue Wang, Lin Liu, Yu He, Yufeng Pei, Li Li, Liying Sun, Zhijun Zhu, Dehua Chang, Jidong Jia, Hong You
Summary: This study compared the therapeutic effects of mesenchymal stem cells (MSCs) and N-acetylcysteine (NAC) on acetaminophen (APAP)-induced liver failure and explored the underlying mechanism. The results showed that MSCs had comparable therapeutic effects to NAC, but had slightly different effects on hepatocyte necrosis and cell infiltration, and attenuated hepatocyte necrosis by secreting hepatocyte growth factor (HGF). These findings provide a theoretical basis for the clinical application of MSCs in treating APAP liver failure.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jialin He, Yan Huang, Jianyang Liu, Ziwei Lan, Xiangqi Tang, Zhiping Hu
Summary: The study conducted a systematic review and meta-analysis of preclinical data on mesenchymal stem cell therapy for multiple sclerosis (MS) and found that MSC administration significantly improved functional recovery and promoted remyelination in rodent models of MS. Despite significant heterogeneity among studies, the overall positive effect of MSCs on functional outcomes and remyelination was evident in the analysis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Shang-Yi Huang, Hsiu-Hsia Lin, Ming Yao, Jih-Luh Tang, Shang-Ju Wu, Wen-Chien Chou, Szu-Chun Hsu, Bor-Sheng Ko, Hwei-Fang Tien
Summary: The study indicates a positive correlation between decorin levels and hepatocyte growth factor levels in patients with multiple myeloma. Patients with low HGF but high decorin levels showed better treatment response rates and overall survival.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Huanjie Chen, Yulong Luo, Yiping Zhu, Yongshun Ye, Difei Chen, Xinyu Song, Zhulin Xiao, Ming Liu, Shiyue Li
Summary: In this study, UCMSCs overexpressing hepatocyte growth factor (HGF) were used to treat pulmonary fibrosis. The results showed that HGF-UCMSCs significantly reduced fibrosis and improved lung function. The overexpression of HGF may enhance the anti-fibrotic effect of UCMSCs by interacting with interleukin-17-producing cells in fibrotic lungs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Satoru Osuka, Dan Zhu, Zhaobin Zhang, Chaoxi Li, Christian T. Stackhouse, Oltea Sampetrean, Jeffrey J. Olson, G. Yancey Gillespie, Hideyuki Saya, Christopher D. Willey, Erwin G. Van Meir
Summary: Glioblastoma is composed of heterogeneous tumor cell populations, including glioma stem cells (GSCs) with stem cell properties. GSCs, which are less radiation sensitive, drive tumor formation and recurrence. Increase in N-cadherin expression enhances radioresistance and stemness in GSCs, while targeting N-cadherin can reverse the radiation resistance phenotype in these cells.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell & Tissue Engineering
Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ryo Kanai, Satoshi Maeda, Shinya Takahashi, Masataka Nagao, Takao Masaki
Summary: Ex vivo-expanded, hypoxia-preconditioned SF-MSCs show promising potential as a cell therapy to prevent renal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Chemistry, Medicinal
Jianqing Yu, George G. Chen, Paul B. S. Lai
Summary: Hepatocellular carcinoma is a major cause of cancer mortality worldwide, with current treatments showing unsatisfactory outcomes. The HGF/c-Met axis is considered crucial in regulating liver diseases and promoting HCC, and inhibiting this pathway may lead to the development of new and effective treatments for HCC.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Rheumatology
Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato, Tohru Takeuchi
Summary: This study investigated the effects of low-molecular-weight heparin (LMWH) on mouse adipose-derived mesenchymal stem cells (mASCs) and their therapeutic effects in mouse models of systemic sclerosis (SSc). The results showed that LMWH-activated mASCs (hep-mASCs) exhibited higher anti-inflammatory and anti-fibrotic effects compared to mASCs alone, suggesting that hep-mASCs may be a promising candidate for SSc treatment.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Oncology
Lucas Eduardo Botelho de Souza, Fernanda Ursoli Ferreira, Carolina Hassibe Thome, Heloisa Brand, Maristela Delgado Orellana, Vitor Marcel Faca, Aparecida Maria Fontes, Dimas Tadeu Covas
Summary: Melanoma cells have the capability to activate an EMT-like program and acquire metastatic traits through distinct pathways induced by MSCs' secretome, both in mouse and human cells.
Review
Cell Biology
Jayden A. Smith, Alexandra M. Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. While current treatments for progressive MS are limited, stem cell transplantation shows promise in providing neurotrophic support, immunomodulation, and cell replacement to combat chronic neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi, Jafar Ai
Summary: Multiple sclerosis (MS) is a chronic central nervous system disease with limited treatment options, leading researchers to explore new therapies such as mesenchymal stromal cell (MSC) transplantation. Allogeneic MSCs are suggested as a potential novel solution for MS therapy as an alternative to autologous MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Amanda Rose Khater, Tamara Abou-Antoun
Summary: Malignant nervous system cancers in children pose a significant challenge due to their aggressive nature and sometimes inoperable location in critical regions. The developmental processes of the nervous system during childhood further complicate treatment modalities. Pediatric oncologists are tasked with providing effective cures while navigating limited therapeutic options to minimize neurotoxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chong Fu, Yan Chen, Wei Xu, Yanping Zhang
Summary: Using genetic data, a Mendelian randomization analysis was conducted to explore the causal relationships between inflammatory cytokines and migraine. The results showed a positive association between hepatocyte growth factor (HGF) and migraine risk, while interleukin-2 (IL-2) was considered a downstream consequence of migraine.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang, Shizhu Jin
Summary: The study demonstrated that HGF-DPSCs can alleviate intestinal mucosa injuries by transdifferentiating into ISC-like cells, promoting ISC-like cell proliferation, suppressing inflammatory responses, and reducing oxidative stress damage, which offers new insights for the clinical treatment of UC.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Arnold I. Caplan, Chris Mason, Brock Reeve
STEM CELLS TRANSLATIONAL MEDICINE
(2017)
Article
Immunology
Benjamin D. Goldstein, Mark E. Lauer, Arnold I. Caplan, Tracey L. Bonfield
JOURNAL OF INFLAMMATION-LONDON
(2017)
Article
Orthopedics
J. Michael Sorrell, Rodrigo A. Somoza, Arnold I. Caplan
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Orthopedics
Arnold I. Caplan
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Engineering, Biomedical
Yi Zhong, Mostafa Motavalli, Kuo-Chen Wang, Arnold I. Caplan, Jean F. Welter, Harihara Baskaran
ANNALS OF BIOMEDICAL ENGINEERING
(2018)
Article
Chemistry, Multidisciplinary
Edgardo Rivera-Delgado, Ashley Djuhadi, Chaitanya Danda, Jonathan Kenyon, Joao Maia, Arnold I. Caplan, Horst A. von Recum
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Cell & Tissue Engineering
Rodrigo A. Somoza, Diego Correa, Ivan Labat, Hal Sternberg, Megan E. Forrest, Ahmad M. Khalil, Michael D. West, Paul Tesar, Arnold I. Caplan
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Diego Correa, Rodrigo A. Somoza, Arnold I. Caplan
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Arnold I. Caplan
STEM CELLS TRANSLATIONAL MEDICINE
(2018)
Article
Orthopedics
Kin R. Murray, Jorge Chahla, Marc R. Safran, Aaron J. Krych, Daniel B. F. Saris, Arnold Caplan, Robert F. LaPrade, Brian J. Cole, Farshid Guilak, Scott A. Rodeo, Christian Lattermann, Mark A. Birch, Bruno Peault, Leela C. Biant, Jorge Chahla, Constance R. Chu, Matthew J. Dalby, Allan B. Dietz, Jason L. Dragoo, Lars Engebretsen, Denis Evseenko, Alan Getgood, Andrew G. Geeslin, Anthony P. Hollander, Johnny Huard, Elizaveta Kon, Aaron J. Krych, Robert F. Laprade, Nicola Maffulli, Bert R. Mandelbaum, Rodrigo Mardones, Iain R. Murray, Frank A. Petrigliano, Marc R. Safran, Daniel B. F. Saris, A. Hamish R. W. Simpson, James H. C. Wang, Henning Madry, Chris H. Jo, Norimasa Nakamura
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2019)
Review
Cell & Tissue Engineering
Wenchun Qu, Zhen Wang, Joshua M. Hare, Guojun Bu, Jorge M. Mallea, Jorge M. Pascual, Arnold I. Caplan, Joanne Kurtzberg, Abba C. Zubair, Eva Kubrova, Erica Engelberg-Cook, Tarek Nayfeh, Vishal P. Shah, James C. Hill, Michael E. Wolf, Larry J. Prokop, M. Hassan Murad, Fred P. Sanfilippo
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Letter
Immunology
Arnold I. Caplan
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2021)
Article
Cell & Tissue Engineering
Tracey L. Bonfield, Morgan T. Sutton, David R. Fletcher, Michael A. Folz, Vaishnavi Ragavapuram, Rodrigo A. Somoza, Arnold I. Caplan
Summary: Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare have significant impact on bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. Current treatment regimens with antibiotic macrolides are often toxic and inefficient. This study demonstrates that human marrow-derived mesenchymal stem cells have antimicrobial and anti-inflammatory effects, suggesting a potential therapeutic approach.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Arnold Caplan
Summary: The Commentary introduces cell-based therapy and discusses the potential criteria that the FDA might establish for the approval of clinical trials and eventual market approval of these cell-based therapeutic products. It emphasizes that considering cell-based therapies as single action drugs is inappropriate given their complexity. The regulatory agencies are slowly reevaluating the criteria for allowing clinical trials using cell-based therapies, and this Commentary offers suggestions for modifying the standard criteria.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Sport Sciences
Thomas M. Best, Arnold Caplan, Michael Coleman, Laurie Goodrich, Jason Hurd, Lee D. Kaplan, Ben Noonan, Philip Schoettle, Christopher Scott, Henry Stiene, Johnny Huard
CURRENT SPORTS MEDICINE REPORTS
(2017)