期刊
NATURE NEUROSCIENCE
卷 15, 期 9, 页码 1195-U38出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3162
关键词
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资金
- US National Institutes of Health [DA027110, GM097433]
- OCTRI
- National Heart, Lung, and Blood Institute [T32HL033808]
Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.
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